Demystifying Lyophilization: Understanding the Freeze-Drying Process - Jubilant HollisterStier
Gain a better understanding of lyophilization, from the initial steps to producing the final product.
Post-Drying in Lyophilization:
Once secondary drying is complete, the post-drying process begins with pre-aeration of the product. During pre-aeration, the vacuum is broken with sterile gas before the vials are stoppered. At JHS, this is done using sterile dry nitrogen or another inert gas. If the vacuum is broken with untreated sterile air, the product might absorb oxygen and water vapor. After pre-aeration is complete, the stoppers are sealed into the vials under a slight vacuum. After the stoppers are fully closed, the vacuum is fully broken with sterile air.
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