SLU-PP-332 Solution Discussion

[narta]

You using something like this? Should work for intranasal too, right?

I have made some sublingual cialis/viagra in the past with success with jello. Fun time.

Intranasal I don't know, I think cyclodextrins have a burning sensation in the mucus membranes, but I might be wrong, it's been years

 

[gburdell]

I have zero direct experience with EO and only have limited experience with DMSO. Gotta get that out of the way first.

I ran some hypotheticals based on DMSO + MCT and EO + MCT with target concentration of 200 mg/ml of SLU-PP-332 and a goal of an intramuscular injectable which is tolerable to humans.

Projection for DMSO + MCT: 150-200 mg/ml concentration feasible at 5-10% DMSO.
Projection for EO + MCT: 200-300 mg/ml concentration easily achievable ay 30-40% EO with 250 mg/ml being realistic and stable.

Both of these should be doable with magnetic mixing alone, but limited low-heat exposure (37-40 C) shouldn't negatively affect the solution. The EO + MCT would be the better of the two choices.

I also checked for other cosolvents that might meet this use case and got benzyl benzoate and glycerol formal as options for higher concentration intramuscular injectables.

I'm curious as to your thoughts on these options.

I haven't had my raws tested, but if they are what they should be, then dissolving the 500mg in 5ml of DMSO was a snap. I think it's going to be key, and I'm fine with taking 5%, but I'm much less gung-ho about pushing the DMSO above that.

Then as I understand it, one either tolerates EO well, or doesn't -- it doesn't seem to bother me, at least not through 3 injections.

My concern about any other carrier oil is the viscosity. At standard temp, the viscosity of EO is 4 mPa·s, MCT is 25, and glycerin 1480.

I have made some sublingual cialis/viagra in the past with success with jello. Fun time.

Intranasal I don't know, I think cyclodextrins have a burning sensation in the mucus membranes, but I might be wrong, it's been years

I'll let you know

 

[gburdell]

I have zero direct experience with EO and only have limited experience with DMSO. Gotta get that out of the way first.

I ran some hypotheticals based on DMSO + MCT and EO + MCT with target concentration of 200 mg/ml of SLU-PP-332 and a goal of an intramuscular injectable which is tolerable to humans.

Projection for DMSO + MCT: 150-200 mg/ml concentration feasible at 5-10% DMSO.
Projection for EO + MCT: 200-300 mg/ml concentration easily achievable ay 30-40% EO with 250 mg/ml being realistic and stable.

Both of these should be doable with magnetic mixing alone, but limited low-heat exposure (37-40 C) shouldn't negatively affect the solution. The EO + MCT would be the better of the two choices.

I also checked for other cosolvents that might meet this use case and got benzyl benzoate and glycerol formal as options for higher concentration intramuscular injectables.

I'm curious as to your thoughts on these options.

Did you find any solubility data on BB?

 

[gburdell]

I have made some sublingual cialis/viagra in the past with success with jello. Fun time.

Intranasal I don't know, I think cyclodextrins have a burning sensation in the mucus membranes, but I might be wrong, it's been years

And I'd meant to post a link to this: https://www.amazon.com/dp/B00HRK49G2 (Amazon.com)

Is this similar to what you're looking to use?

 

[narta]

And I'd meant to post a link to this: https://www.amazon.com/dp/B00HRK49G2 (Amazon.com)

Is this similar to what you're looking to use?

No. CAS:94035-02-6