ZyzzReincarnate
New Member
Okay. But why?That doesn't make sense. I mean, it's just wrong.
Okay. But why?That doesn't make sense. I mean, it's just wrong.
think you meant 1.42mg/dayI dont see how that could be the case. 10mg Ngenla per week would be equivalent to 10 ÷ 7 = 1.42iu/day. That does depend on the half live though. I'm not saying this is fact, just saying what I think
Yeah, thats the golden question. I'm sure we'll all find that out at some point since Ngenla seems to be getting lots of attention. Its still early days. I predict, that at somepoint, we'll all have access to Ngenla from vendors such as QSC.think you meant 1.42mg/day
in IUs this would be 4.26iu/day, although I don't know if the new long acting GH scales the same way as tradition rHGH would on a iu/mg basis.
the more bloodwork that comes in, the better the information we'll have.Yeah, thats the golden question. I'm sure we'll all find that out at some point since Ngenla seems to be getting lots of attention. Its still early days. I predict, that at somepoint, we'll all have access to Ngenla from vendors such as QSC.
*oh yeah. I didnt read it as 10mg, but rather 10ius. So yeah, 10mg x3 = 30iu. 30iu/7 days = 4.28ius/day.
We dont know if it add up like that though.
Agreed.the more bloodwork that comes in, the better the information we'll have.
Bloodwork can still be tricky though because IGF-1 levels can vary for a multiple of reasons, and responses to the drug will vary greatly from person to person so the best data would come from a person thats doing very frequent bloodwork and chronologically tracking the changes.
even GH serum levels could vary a lot with NGENLA because it has a wide window in which it peaks.
NGENLA® (somatrogon-ghla) Clinical Pharmacology | Pfizer Medical Information - US
NGENLA® (somatrogon-ghla) Clinical Pharmacology 12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action Somatrogon-ghla binds to the GH receptor and initiates a signal transduction cascade culminating in changes in growth and metabolism. Somatrogon-ghla binding leads to activation of the STAT5b...www.pfizermedicalinformation.com
- Subq administration -- serum levels peaked within 6 to 25 hours, with a median of 11 hours
- IGF 1 levels peak about 48 hours after the dose. Average weekly IGF occurring 4 days post dose.
- Estimated half life 37.7 hours
- Elimination life of 8 days post dose
I'm not saying you're wrong, but I find that really hard to get my head around.-A weekly dose of NGENLA at 0.66 mg/kg or
-A daily dose of somatropin at 0.034 mg/kg (corresponding to 0.238 mg/kg per week.
resulted in comparable outcomes in adolescents. Extrapolating from the above, we can say that:
To emulate the results of 5IU of GH per day (~12mg GH per week), you would need (0.66/0.238)*12 = 33.27mg NGENLA per week. So roughly half a pen per week.
Needless to say, GH is much cheaper to run. It has a better safety profile, too. If you really hate pinning yourself, or if you need to travel and can't bring your GH, then sure, take some NGENLA. For everyone else GH reins supreme.
do you have the link for this data? I know where you got the .66mg/kg from. Whered you get the somatropin data?-A weekly dose of NGENLA at 0.66 mg/kg or
-A daily dose of somatropin at 0.034 mg/kg (corresponding to 0.238 mg/kg per week.
resulted in comparable outcomes in adolescents. Extrapolating from the above, we can say that:
To emulate the results of 5IU of GH per day (~12mg GH per week), you would need (0.66/0.238)*12 = 33.27mg NGENLA per week. So roughly half a pen per week.
Needless to say, GH is much cheaper to run. It has a better safety profile, too. If you really hate pinning yourself, or if you need to travel and can't bring your GH, then sure, take some NGENLA. For everyone else GH reins supreme.
Because pharmacology.Why would Ngenla need to be dosed x2.77 more than GH?
do you have the link for this data? I know where you got the .66mg/kg from. Whered you get the somatropin data?
so basically theres a multiplier of 2.77
such that 2.77mg of ngenla is the equivalent of 1mg (3iu) of rHGH
yeah that doesn't seem very cost efficient, not to mention the increase in insulin resistance from the long half life
You do have to consider, according to a quick search, A 100iu kit of GH would go for $1000 - $1500 in the 1990s. Today, many of us are buying kits GH for $55 each.do you have the link for this data? I know where you got the .66mg/kg from. Whered you get the somatropin data?
so basically theres a multiplier of 2.77
such that 2.77mg of ngenla is the equivalent of 1mg (3iu) of rHGH
yeah that doesn't seem very cost efficient, not to mention the increase in insulin resistance from the long half life
I must have read the same study too as I've also heard that number before. Definately rings a bell.whered you get the somatropin number though?
was it from the same study or a different study using the same controlled variables?
thank you!About NGENLA™ (somatrogon-ghla) Injection
See risks & benefits. Explore NGENLA clinical trial results and find answers to questions you might have about the safety of the prescription treatment option.www.ngenla.com
How about you look at the wikipedia page of Somatrogon before spouting nonsense? Considering also your retarded attempt at a calculation on the last page, I suggest you take a back seat on this one.*"Why would Ngenla need to be dosed x2.77 more than GH?"*
The only reason I can hypothesise is that Ngenla has some form of "ester" attached to it which slows its release into the blood.
Now if Ngenla had some form of ester(s), the molecular weight of those esters would need to be taken into consideration. Ngenla might not be 100% pure GH. Like how 100mg Testosterone Cypionate is only 72mg pure testosterone because 28mg is the cypionate ester!
Now, IF thats the case, how much pure GH is there in a given quantity of Ngenla?!
You heard it here first folks!thank you!
looks like 2.77 is the official ratio
I already have buddy. Weeks ago. Ngenla is fairly new, it must be getting updated with new infoHow about you look at the wikipedia page of Somatrogon before spouting nonsense? Considering also your retarded attempt at a calculation on the last page, I suggest you take a back seat on this one.