Sublingual semaglutide/tirzepatide

[Spaceman Spiff]

Has anybody made it? That's the only question say whatever opinions you may have regarding its efficacy

What is SNAC in oral semaglutide? | Biopharma PEG

Peptidesandproteinsplayanincreasinglyimportantroleinthetreatmentofmanydiseases,...

www.biochempeg.com

 

[Avies48]

Here ya go sevencells is now offering it

 

[kain]

People will make anything they think will generate profit. Just fucking inject it like it’s supposed to be done. Don’t be a pussy.

 

[Ghoul]

Looking at the various sites selling this stuff, some say to use it once a week, others say daily. Some say hold it in your mouth for 90 seconds, others say no less than 5 minutes (!).

One says "No guarantee of efficacy", probably the most accurate statement of them all.

 

[HB_22]

Then why do compounding pharmacies make it? Why was Rybelsus developed? It's obviously just another method of administration, nothing absurd about it.

People are afraid of injecting it.

 

[AlexDavis43]

injection = Ozempic 0.5-2 mg/wk

oral tablets = Rybelsus 3-14 mg/d = 21 - 98 mg/wk

There is no once weekly dosing of the oral. It's daily and way more than subQ.

Some people haven't crossed the line of injecting yet. We were all there once. Not judging.

 

[Spaceman Spiff]

People are afraid of injecting it.

I remember when I was hesitant...


Then I went full retard injecting 4+ different things a day every day.

HGH twice a day, Carnitine, some random peptide. AAS


Now I am so reluctant to inject shit. not even what to inject but just finding a spot lol.

 

[empathicpelican]

The real question is how expensive is it to synthesize GLP-1s in a standard lab? Take paracetamol. Synthesizing 2,800 mg would e.g., cost a few cents at best - but paracetamol is a rather easy synthesis, and i assume sema is much harder. But perhaps with scale you could do it cheaply. Otherwise, Chinese chemists need to get back to the drawing table and figure out some other GLP-1s with better sublingual bioavailability

 

[mochul]

The real question is how expensive is it to synthesize GLP-1s in a standard lab? Take paracetamol. Synthesizing 2,800 mg would e.g., cost a few cents at best - but paracetamol is a rather easy synthesis, and i assume sema is much harder. But perhaps with scale you could do it cheaply. Otherwise, Chinese chemists need to get back to the drawing table and figure out some other GLP-1s with better sublingual bioavailability

Peptides are different than other molecules. It requires multiple steps, with each step elongating the peptide chain. The longer the peptide chain, the longer the required steps. Upscaling production is not simple too.

 

[empathicpelican]

I'm no organic chemist so don't have a sound perspective on sema production. But insuline was also v hard to make initially before it became easier & cheaper & better. Took a couple decades. But perhaps we'll see production techniques progress faster this time around