I must be the guy that’s full of shit. I’ve written this before on MESO...
LC/MS/MS is much more accurate than the standard ECLIA. Give it a try the next time and compare your results running the same amount of test and AI. You’re going to see different values.
The ECLIA was primarily for women and they obviously have higher E2 cause well, they’re women [emoji2369] (about 4-5x higher).
When men use the ECLIA our levels are lower and the accuracy of the method suffers. You’re getting “ballpark” numbers back and those can be 10, 20, 30 pg/ml higher. Not much but could be the difference between a result of 30 and 60. With an inaccurate reading of 60 you’re upping your AI dose but your ACTUAL E2 level is 30 so you come close to crashing it based on an inaccurate number from your blood tests.
The LC/MS/MS is much more accurate and returns a real value. It’s sensitive enough to pick up the lower male values more precisely.