hey liska
no, don't worry, the boy in question wasn't using your shitty GH; she goes back to selling fake or expired Pharmaqo lots
when you have a decent GH for sale that is free of crap come back to this forum
MESO-Rx
Anabolic Steroids
Tell us your top 3 ugl HGH ?
- Thread starter MONSTRO1977
- Start date
no, don't worry, the boy in question wasn't using your shitty GH; she goes back to selling fake or expired Pharmaqo lots
when you have a decent GH for sale that is free of crap come back to this forum
Liska
Subscriber
As a Qingdao rep you should contact Millard right away to get tagged as such or members will think you're not getting "a free gift" for slandering other brands as your post history indicates. Until then it may be you who should not be on this forum.
Do you want to compare yourself with QSC? where I come from they say "Let's not confuse shit with meat"
Liska
Subscriber
Anytime but check with (Not)Alisa 2.0 if you want to yccreate unnecessary trouble for your master.
Type-IIx
Well-known Member
Indeed; you'll start to experience diminished benefits to total-body anabolism and more severe deleterious side-effects like hyperglycemia.
liska is TOP , i love liska ; top product 100% legit
Type-IIx
Well-known Member
It's a valid hypothesis and I can see exactly why, theoretically, you might optimistically view Jardiance's effects on IGF-IR as potentially analogous to Tren's effects on satellite cell responsiveness to autocrine/paracrine IGF-I.
Empagliflozin Induced Ketosis, Upregulated IGF-1/Insulin Receptors and the Canonical Insulin Signaling Pathway in Neurons, and Decreased the Excitatory Neurotransmitter Glutamate in the Brain of Non-Diabetics
Sodium-glucose cotransporter-2 inhibitors (SGLT2is), such as empagliflozin, lower blood glucose in type 2 diabetes mellitus and improve cardiorenal outcomes regardless of diabetes presence. Whether SGLT2is exert any effects on the brain’s metabolism ...www.ncbi.nlm.nih.gov
It is related to IGF1R on brain, not in skeletal muscle
about serum IGF-1, if its able to increase or decrease, it same thing as Tren, it does decrease serum IGF1 but it helps on upregulation, so, its not the same thing. I tought jardiance would help in muscle igf1 upregulation, but it doesnt matter I think
It's quite clever.
However, this is very new data with respect to this Jardiance effect. I would not be surprised to learn that the mechanism underpinning its upregulating IGF-IR (#/expression) is a result of the decrement to IGF-I per se; just a counterregulatory mechanism.
Conversely, trenbolone's effects on SC responsiveness to mIGF-I (IGF-IEa; IGF-IEc) are, rather than some ancillary benefit, a primary mechanism in its muscle anabolism, along with suppressed expression of GR, MuRF1 & atrogin-1 mRNA.
TheDieselZ
New Member
So theoretically best to cycle hgh, or at least go through phases of high and low dose hgh use to keep your igf response good?
Manzoitaly
Subscriber
If hgh is hormone with pulsation, like insulin. Maybe there is a desensibilization, like insulin in long term. I see this, for this i use eod or 5/2, i take break of 60-90 days, for '' possible desensibilization'' and for side like retention and for blood sugar
Type-IIx
Well-known Member
I discuss the principles of rational rhGH use in Bolus, my forthcoming book, to be released very soon, some people are reviewing sections now and the site is being built. It is indeed a principle that rhGH use is best use cyclically or in combination with agents that increase IGF-I bioavailability. Insulin is one, potent one. I discuss other solutions in the book.
TheDieselZ
New Member
How long are you blasting before 60-90 day break
AlexDavis43
Member
Sweeeet (emphasis mine)
AlexDavis43
Member
Glycemic consequences in long-term GH use is fairly well-documented. This meta-analysis included studies 6-12 months and >12 months and confirms.
I had a harder time finding long-term GH or IGF-1 use on anabolism. This 8-week study (not even close to long-term) confirmed bro-science: increased protein anabolism and fat oxidation.
Fat loss effects were maintained for 9 months of IGF-1 treatment which reversed upon cessation in this study. No comment on muscle but no changes in urinary nitrogen (possibly a very crude marker).
I'm sure the effects of long-term treatment with GH will differ from long-term treatment with IGF-1 on anabolism, although I'm not familiar with those studies.
These fuckers said GH treatment in adults with normal pituitary function doesn't do anything:
@TheDieselZ
clearheaded
Member
ill just leave this here...
pubmed.ncbi.nlm.nih.gov
GH serum anyone? lol
The effect of topically applied recombinant human growth hormone on wound healing in pigs - PubMed
The beneficial wound healing effect of the systemic growth hormone (GH) mediated by insulin-like growth factor 1 (IGF-1) has been widely reported. Recent studies have suggested that GH facilitates wound healing not by circulating IGF-1, but by local IGF-1 produced in the wound itself. The aim of...
pubmed.ncbi.nlm.nih.gov
GH serum anyone? lol
Type-IIx
Well-known Member
Yep, there's always some gate-keeping by the medical community, same with their view that insulin's basically not protein anabolic, which we know is quite hilarious. Of course, the pre-Bhasin view on AAS, similarly hilarious.
I really do get into the weeds with changes with different time-courses of rhGH administration.
Some outcomes have very long time-courses, e.g., muscular strength (linear between 5 - 7 years, at least in replacement for adult GHD); bone mineral density/content is bi-phasic, actually resulting in a decrease for the first 6 mo due to augmented bone metabolism, with net breakdown initially.
AlexDavis43
Member
ill just leave this here...
The effect of topically applied recombinant human growth hormone on wound healing in pigs - PubMed
The beneficial wound healing effect of the systemic growth hormone (GH) mediated by insulin-like growth factor 1 (IGF-1) has been widely reported. Recent studies have suggested that GH facilitates wound healing not by circulating IGF-1, but by local IGF-1 produced in the wound itself. The aim of...
GH serum anyone? lol
I remember a professor telling us a story: "a dog licks it's wounds" may have biological rationale. They have IGF-1-like growth factors in their saliva, so licking wounds accelerates healing.
Your dog might instinctively lick a wound on your body for the same reason.
I don't know how much is true but cool story.
"Growth Hormone (GH) and Wound Healing" is a good read on the topic.
clearheaded
Member
also BPC is found in saliva IIRC...
AlexDavis43
Member
It looks like this comment is directly replying to my comment. Why do a new comment instead of replying? Replies register differently in my notifications, so I go to them first.
*this isn't a source thread so I don't feel like an asshole asking off-topic questions
clearheaded
Member
didn't know that was a thing.. thanks for the info.
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