Thyroid and genetic mutation

[TRTedAF69]

For the people who have quite some knowlegde on the thyroid and the DIO enzymes. I need your help.
My whole life I've struggled to lose weight.
Felt like ass and tired.
Unless I did a carnivore diet.
But it's so restrictive I can't be bothered. Honestly I like my carbs.

So I found this genetic mutation on my DIO 2 enzyme Thr92Ala
Despite having normal TSH levels and T4 levels.
Always felt like I had a shitty metabolism.
As far as I know it shows I have a issue converting T4 into T3.

Would it be interesting for me to pursue medication for someone who isn't on meds yet?

 

[Sector]

The bloodwork for TSH, T3 and T4 were all good?

 

[TRTedAF69]

The bloodwork for TSH, T3 and T4 were all good?

So TSH was always around 2 so normal. T4 always near top range
FT3 was always low normal.
I'm waiting on my latest testing which has FT3 FT4 and RT3 in it. Should receive it any time now.

 

[Sector]

I'll probably let someone more advanced in medical and bloodwork chime in with regards to that

I will say that some people have a genetic disposition towards obesity, but that's not to say that you can't fix it with diet and training. I know you said you love carbs, but in the context of cutting its probably better to limit carbs to around training, or at the very least carb cycle

 

[Sector]

@readalot

Thoughts?

 

[TRTedAF69]

Y

I'll probably let someone more advanced in medical and bloodwork chime in with regards to that

I will say that some people have a genetic disposition towards obesity, but that's not to say that you can't fix it with diet and training. I know you said you love carbs, but in the context of cutting its probably better to limit carbs to around training, or at the very l

east carb cycle

I'll probably let someone more advanced in medical and bloodwork chime in with regards to that

I will say that some people have a genetic disposition towards obesity, but that's not to say that you can't fix it with diet and training. I know you said you love carbs, but in the context of cutting its probably better to limit carbs to around training, or at the very least carb cycle

Yeah I agree issues is I get insulin resistant on anything around 100gr carbs.

So I have no issues going lower carb but 50gr is nothing really which would always mean that 1 holiday would fuck me up If I ate a couple of pizza's in italy.

 

[readalot]

waiting on my latest testing

TSH

FT3 FT4

Yes. Post them up.

Find a good Endo. You would might benefit from combination thyroid therapy (levothyroxine plus liothyronine). You've got some data and should pursue this with Doctor you trust, not forum weirdos (me).

DIO2 Thr92Ala Reduces Deiodinase-2 Activity and Serum-T3 Levels in Thyroid-Deficient Patients

We demonstrated that thyroidectomized patients carrying enzymatic deficient Thr92Ala have reduced intracellular and serum T3 concentrations that are not ad

academic.oup.com

Pathophysiological relevance of deiodinase polymorphism

To assess new findings and clinical implications of deiodinase gene polymorphism. Deiodinases are enzymes that can activate or inactivate thyroid hormone molecules. Whereas the types 1 and 2 deiodinase (D1 and D2) activate thyroxine (T4) to 3,5,3[’] ...

www.ncbi.nlm.nih.gov

T4+T3 Combination Therapy: An Unsolved Problem of Increasing Magnitude and Complexity

Thyroxine (T4)+triiodothyronine (T3) combination therapy can be considered in case of persistent symptoms despite normal serum thyroid stimulating hormone in levothyroxine (LT4)-treated hypothyroid patients. Combination therapy has gained popularity in ...

www.ncbi.nlm.nih.gov

The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Higher Body Mass Index and Fasting Glucose Levels: A Systematic Review and Meta-Analysis

Type 2 deiodinase (Dio2) is a selenoenzyme that is mainly expressed in the endoplasmic reticulum of the central nervous system, brown adipose tissue, and placenta and is responsible for outer ring deiodination of thyroxine (T4) to form biologically active ...

www.ncbi.nlm.nih.gov

TSH, fT3, fT4 are the markers you want to pull. Congrats on getting those run.

As far as I know Endos still aren't doing tissue biopsies and comparing with serum thyroid levels. So what's left is pull the appropriate blood work, work patient up based on symptoms, then stepwise titrate the 3 parameters above. Exogenous T3 gives the provider an extra treatment knob.

 

[TRTedAF69]

Yes. Post them up.

Find a good Endo. You would might benefit from combination thyroid therapy (levothyroxine plus liothyronine). You've got some data and should pursue this with Doctor you trust, not forum weirdos (me).

DIO2 Thr92Ala Reduces Deiodinase-2 Activity and Serum-T3 Levels in Thyroid-Deficient Patients

We demonstrated that thyroidectomized patients carrying enzymatic deficient Thr92Ala have reduced intracellular and serum T3 concentrations that are not ad

academic.oup.com

Pathophysiological relevance of deiodinase polymorphism

To assess new findings and clinical implications of deiodinase gene polymorphism. Deiodinases are enzymes that can activate or inactivate thyroid hormone molecules. Whereas the types 1 and 2 deiodinase (D1 and D2) activate thyroxine (T4) to 3,5,3[’] ...

www.ncbi.nlm.nih.gov

T4+T3 Combination Therapy: An Unsolved Problem of Increasing Magnitude and Complexity

Thyroxine (T4)+triiodothyronine (T3) combination therapy can be considered in case of persistent symptoms despite normal serum thyroid stimulating hormone in levothyroxine (LT4)-treated hypothyroid patients. Combination therapy has gained popularity in ...

www.ncbi.nlm.nih.gov

The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Higher Body Mass Index and Fasting Glucose Levels: A Systematic Review and Meta-Analysis

Type 2 deiodinase (Dio2) is a selenoenzyme that is mainly expressed in the endoplasmic reticulum of the central nervous system, brown adipose tissue, and placenta and is responsible for outer ring deiodination of thyroxine (T4) to form biologically active ...

www.ncbi.nlm.nih.gov

TSH, fT3, fT4 are the markers you want to pull. Congrats on getting those run.

As far as I know Endos still aren't doing tissue biopsies and comparing with serum thyroid levels. So what's left is pull the appropriate blood work, work patient up based on symptoms, then stepwise titrate the 3 parameters above. Exogenous T3 gives the provider an extra treatment knob.

Thank you for your response!
My labs are:
TSH 1.8 ( 0.27 - 4.2 )
FT4 1.3 ng/dl ( 0.93 - 1.7 )
FT3 3.5 pg/ml ( 2.0 - 4.4 )

So on paper.
My labs are very good.
However my functional meds doctor told me this.
He said.
Your brain isn't detecting any T3 or isn't able to convert it.
So your body is fine but your mind is not.

The other issues this is giving me is that my cortisol levels are crashed. So I'm running on adrenaline which is giving me insulin resistance.

But that doctor is going to prescribe me T3 monotherapy.
He couldn't be bothered with the T4 he said because my brain ain't converting it.

Thanks for the input man.

 

[readalot]

functional meds doctor

So your body is fine but your mind is not.

Sorry Man. Best wishes on the journey to find a solution that works for you. The brain/body/T3 statements are nonsensical.

 

[readalot]

Your brain isn't detecting any T3 or isn't able to convert it.

My labs are:
TSH 1.8 ( 0.27 - 4.2 )
FT4 1.3 ng/dl ( 0.93 - 1.7 )
FT3 3.5 pg/ml ( 2.0 - 4.4 )

 

[Mrhairyman]

What does your Doctor say ?
I was born with a hypo-active thyroid, hereditary . I have been taking Synthroid my entire life.
It is extremely hard to maintain a "normal" weight / cholesterol , but these are the cards I was dealt with, I am blessed it's only this and not something worse.