Training, Diet, and AAS Usage In Individuals With Autoimmune Disorders

fike

Member
I started feeling like a big ol' bag of mashed up assholes somewhere around the end of 2012. I was constantly fatigued, gaining weight, muscle and joints were tender and painful, blood sugar was high, depression set in, and my knuckles started growing in size. There were dozens of trips to the doctor and enough bloodwork done that every phlebotomist in the VA hospital was on a first name basis with me. What did this bloodwork reveal, you may be wondering? Not a motherfucking thing. I was 27 years old and had a total testosterone level of 235 ng/dl. I was diagnosed with chronic fatigue syndrome and major depressive disorder. I was prescribed a shit ton of antidepressants and sent to a therapist. Years went by and there was never any improvement and symptoms were progressively getting worse. I didn't know what to do. I was convinced something was mentally wrong with me and accepted this as my life.

I was 28 when I decided that I had was sick and tired of being sick and tired and I had to try something else. This was around the time that the keto diet was picking up a lot of steam, so I decided I was going to give that a try to lose weight and start working out. Within a month of becoming disciplined enough to stick to the diet and perform bodyweight exercises daily, the weight seemed to melt off. I had lost something close to 20 pounds within the first month. I felt like a different person. My joints weren't as inflamed, red, and irritated and my energy levels were through the roof for the first time in years. I remember thinking surely diet and exercise couldn't have such a dramatic effect in such a short period of time, so I began doing some more research. What I essentially came to realize is that when I started dieting I had began an elimination diet of foods that cause massive amounts of inflammation in many people. This prompted me to go to my primary care doctor and talk to him about what had been going on with me. Although my joints were hurting as bad, the swelling and signs of arthritis remained visible (as they still do today). My doctor listened to my prior symptoms and what I had done to achieve some relief and examined my hands. The first thing he said is, "we are going to run an autoimmune panel on you because you show the signs of rheumatoid arthritis." Thank God he did this, because I discovered that I wasn't crazy and there was a clear cut diagnosis as to why I had been having problems all these years. I was diagnosed with system lupus erythematosus and was placed under the care of an awesome rheumatologist.

Now with all that being said, lupus mainly affects women. It is thought to be partially influenced by hormonal factors. Finding this out, I started haphazardly experimenting with different compounds to lower estrogen and raise my testosterone. Enclomiphene was my first compound and I saw some pretty amazing results. At 25 mg per day for 12 weeks, I was able to lower my E2 to 20 and raise my total testosterone to around 850 if I remember correctly. This sent me down a rabbit hole of cycling on and off different SARMs and other compounds for a while and weight training hard 6 days a week. I didn't realize the importance of rest and recovery until a couple years ago when the lupus started flaring up on me and making recovery harder, sometimes overtraining and putting me down for up to 4 days. Knowing what I know now, I progress just fine doing and upper body, lower body, rest day split and taking an extra day if I need to. Listening to what my body is telling me is key. I don't lift competitively and I'm never going to step on stage for a physique competition. The only person I'm competing against is myself and how much I lifted the previous week. I had to learn to leave my ego at the door and not be so hard on myself when I fell short of the mark.

The introduction of exogenous testosterone was a game changer for me in how I felt and the progression of my disease. Even at simple TRT dosages of 140-160 mg per week was enough to put almost put a halt to my flare-ups for the past two years. It lowered my need for opioid pain medication dramatically and spiced up things between my wife and I. This shores up my belief that lupus has something to do with hormones, estrogen in particular. My current TRT protocol is 200 mg per week of test cyp, 100 mg per week of nandrolone decanoate, and 500 IUs of HCG twice weekly to maintain fertility and keep the boys plump. The deca wasn't added to my protocol until around 6 months ago, but within one month, I was almost pain free until night time when I laid down for bed. The deca has done wonders for my joint pain and I don't have a side effects from the 100 mg dose. I am now down to 5 mg of methadone daily for pain management and I feel better than I have in years, other than the occasional muscle tenderness and back pain from breaking my back in the military. I am eternally grateful for these compounds being readily available and I believe they are very underutilized in the treatment of some autoimmune disorders and diseases.

Are there any other members here that have autoimmune issues and if so, have you found your training, diet, and AAS protocol to be beneficial in slowing down or stopping the progression of your disease?

I know that was a long post, but I appreciate y'all pushing through if you read it. I am interested in your experiences and open to trying some of your tactics if you are willing to share. Thanks.
 
The first time I read about AAS for treating autoimmune disorders was in the book: Anabolic Therapy in Modern Medicine by William Taylor

It is very pro-AAS in medicine. It will confirm any favorable biases you have regarding AAS as therapies for various conditions. It is referenced (but maybe cherry-picked I don't know). I would definitely recommend reading more critical assessments to balance it out.
 
This shores up my belief that lupus has something to do with hormones, estrogen in particular.
alot in this post but I do not believe this is connected. just shit luck and a bad draw of cards in life.



I will never understand why they use DECA in these protocols. half the time to me it is just them slaming whatever FDA approved medication they can throw at the patient for an upcharge.

What does the Rheum say about this?
 
alot in this post but I do not believe this is connected. just shit luck and a bad draw of cards in life.



I will never understand why they use DECA in these protocols. half the time to me it is just them slaming whatever FDA approved medication they can throw at the patient for an upcharge.

What does the Rheum say about this?
Sorry if the post was a little scattered. My mind was a little racey.

It may be shit luck for sure, but being a layman, I tend to connect things that may or may not be present in myself from reading studies and then analyzing what is going on with my body. Mental gymnastics is a definite possibility. Another reason there could be such a disparity in the number of women to men who have lupus (10:1) is that men are less likely to go to the doctor with problems like fatigue and depression, so it could be under diagnosed, but I don't know.

The addition of the deca comes from my TRT doc, so what you said about the uncharging could be the reality of it, but anecdotally, I can tell a huge difference. I try my best to go into new medication use with a skeptical mind, because I have had very limited success when it comes to lupus management. Corticosteroids steroid gave me the most symptom relief in the past before my AAS use, but long-term corticosteroid use is nasty.

Rheumatologist pretty much says, "whatever works." She didn't recommend for or against it as long as my kidney function, AST, and ALT are all staying within range, which so far they have. Only time my kidney function is ever off is when I get blood work done a day or two after a hard training session when my BUN and creatinine is high. My nephrologist says it's not uncommon for this to be seen in athletes.
 
The first time I read about AAS for treating autoimmune disorders was in the book: Anabolic Therapy in Modern Medicine by William Taylor

It is very pro-AAS in medicine. It will confirm any favorable biases you have regarding AAS as therapies for various conditions. It is referenced (but maybe cherry-picked I don't know). I would definitely recommend reading more critical assessments to balance it out.
Thanks for the recommendation. I will definitely give it a read. I don't know if I need any confirmation bias for my AAS use, though. :p I actually haven't been able to find too many studies--at least not recent studies--on AAS use to treat autoimmune disorders. I should probably crawl pub med a little more in depth to see if I can find any more nays and yays on the issue.
 
If I remember correctly, the book had lots of references that you may find helpful. Unfortunately, I don't have a copy of the book at the moment.
 
Sorry if the post was a little scattered. My mind was a little racey.

It may be shit luck for sure, but being a layman, I tend to connect things that may or may not be present in myself from reading studies and then analyzing what is going on with my body. Mental gymnastics is a definite possibility. Another reason there could be such a disparity in the number of women to men who have lupus (10:1) is that men are less likely to go to the doctor with problems like fatigue and depression, so it could be under diagnosed, but I don't know.

The addition of the deca comes from my TRT doc, so what you said about the uncharging could be the reality of it, but anecdotally, I can tell a huge difference. I try my best to go into new medication use with a skeptical mind, because I have had very limited success when it comes to lupus management. Corticosteroids steroid gave me the most symptom relief in the past before my AAS use, but long-term corticosteroid use is nasty.

Rheumatologist pretty much says, "whatever works." She didn't recommend for or against it as long as my kidney function, AST, and ALT are all staying within range, which so far they have. Only time my kidney function is ever off is when I get blood work done a day or two after a hard training session when my BUN and creatinine is high. My nephrologist says it's not uncommon for this to be seen in athletes.
you are right, but you dont want to deal with medication interactions. My problem is some of these TRT clinics just use "Hormone specialists" or people who follow an algorithm to make the most amount of money. some of them have degrees completely unrelated.

I dont like it when they step out of lines with people that have other health conditions and try to play doctor when they shouldnt be touching that shit.

basic things like BP, uncontrolled BG from HGH. Whatever, they can manage that but nothing more. Nor they should ever be advising people. I have gotten into it with some of them on forums where they are self proclaimed health experts.

Im done with my TRT clinic rant. I do use them for legal protection that I am on Testosterone.


I am glad that the rheum is in agreement and that is the most important thing at the end of the day. Is the specialist of your condition, for, against, or doesnt care.

I truly wish you luck. I hope you find the right protocol for you. terminal conditions are terrible to deal with but seems like you are on the right track.
 
I am glad that the rheum is in agreement and that is the most important thing at the end of the day. Is the specialist of your condition, for, against, or doesnt care.

I truly wish you luck. I hope you find the right protocol for you. terminal conditions are terrible to deal with but seems like you are on the right track.
I with you on what you were saying on the TRT clinics. A lot of them are just quick moment makers that don’t really put the health of it‘s patients first. I’ll get off that too, though.

I appreciate the well-wishes. I’m probably going to need them as I get older and the disease progresses. I’m not naive enough to believe my current relief will last forever, but thank Jesus it has helped for now. I’ve found something that has helped for the past couple of years and this protocol isn’t too far fetched in its scientific backing or woo woo. I feel like that has something to say for itself.
 
I have felt my best with hgh usage specifically in the am. Like night and day difference. That wasn’t something I was expecting.
It’s a long story and my auto immune issue was medically caused so definitely not the same as what you are dealing with. Low e2 absolutely wrecks me. I feel better on the higher end of normal. Recently started trying synapsin and seeing some benefits.
But it’s the I get back up and get knocked down. The always being reminded I’m never going to be who/what I was health wise.
 
I have felt my best with hgh usage specifically in the am. Like night and day difference. That wasn’t something I was expecting.
It’s a long story and my auto immune issue was medically caused so definitely not the same as what you are dealing with. Low e2 absolutely wrecks me. I feel better on the higher end of normal. Recently started trying synapsin and seeing some benefits.
But it’s the I get back up and get knocked down. The always being reminded I’m never going to be who/what I was health wise.
I haven’t done much research into HGH use in regards to my specific autoimmune issue, but i will definitely look into it. I actually just got a couple kits not long ago, but haven’t committed to them yet, because i’ve already got a few compounds going on my with my current blast.

I have looked into some other peptide compounds like TB500 and BPC-157. I did actually have some luck with the TB500. My inflammation markers went down pretty significantly during my experiment with this, but that damn peptide is fairly expensive to use long term in the dosage that are thought to be therapeutic. It really helped with my recovery and injury resilience. But it’s the I get back up and get knocked down. The always being reminded I’m never going to be who/what I was health wise.
But it’s the I get back up and get knocked down. The always being reminded I’m never going to be who/what I was health wise.
This is very humbling, isn’t it? I’m grateful every day for what I have remaining in regards to my health. We definitely shouldn’t take it for granted.
 
The two times I tired to get tb500 and bpc-157 they were bunk so I gave up on trying them. Though know there’s better sources for it, I may revisit them. I have no clue why the hgh makes me feel better and gets rid of the brain fog. One of this e again we have some decent sources so glad since I needed to get more and don’t want to not have it on hand.
It’s been a long road from hell I wouldn’t wish on anyone. I am grateful that I’m better than I thought I’d ever get at one point. But it’s hell trying to hang onto that health I gained and the docs sure as hell aren’t always the ones with answers or help.
 
It’s been a long road from hell I wouldn’t wish on anyone. I am grateful that I’m better than I thought I’d ever get at one point. But it’s hell trying to hang onto that health I gained and the docs sure as hell aren’t always the ones with answers or help.

Doctors definitely don't always have the answers, but we have to remember they are very confined to a very narrow set of treatment options much of the time. I don't know too many physicians that will go off label with medications even if evidence from studies are presented to them. They are worried about their license, and that is understandable. Lucky for us, we have the resources available today to do research of our own and use ourselves as proverbial guinea pigs. I'm not implying anyone should step outside the confines of their doctor's recommendations and treatments (I am no doctor or medical expert) and don't necessarily advocate for this approach for others, but it is nice to me to be able to source alternate treatment options and experiment.
 
I started feeling like a big ol' bag of mashed up assholes somewhere around the end of 2012. I was constantly fatigued, gaining weight, muscle and joints were tender and painful, blood sugar was high, depression set in, and my knuckles started growing in size. There were dozens of trips to the doctor and enough bloodwork done that every phlebotomist in the VA hospital was on a first name basis with me. What did this bloodwork reveal, you may be wondering? Not a motherfucking thing. I was 27 years old and had a total testosterone level of 235 ng/dl. I was diagnosed with chronic fatigue syndrome and major depressive disorder. I was prescribed a shit ton of antidepressants and sent to a therapist. Years went by and there was never any improvement and symptoms were progressively getting worse. I didn't know what to do. I was convinced something was mentally wrong with me and accepted this as my life.

I was 28 when I decided that I had was sick and tired of being sick and tired and I had to try something else. This was around the time that the keto diet was picking up a lot of steam, so I decided I was going to give that a try to lose weight and start working out. Within a month of becoming disciplined enough to stick to the diet and perform bodyweight exercises daily, the weight seemed to melt off. I had lost something close to 20 pounds within the first month. I felt like a different person. My joints weren't as inflamed, red, and irritated and my energy levels were through the roof for the first time in years. I remember thinking surely diet and exercise couldn't have such a dramatic effect in such a short period of time, so I began doing some more research. What I essentially came to realize is that when I started dieting I had began an elimination diet of foods that cause massive amounts of inflammation in many people. This prompted me to go to my primary care doctor and talk to him about what had been going on with me. Although my joints were hurting as bad, the swelling and signs of arthritis remained visible (as they still do today). My doctor listened to my prior symptoms and what I had done to achieve some relief and examined my hands. The first thing he said is, "we are going to run an autoimmune panel on you because you show the signs of rheumatoid arthritis." Thank God he did this, because I discovered that I wasn't crazy and there was a clear cut diagnosis as to why I had been having problems all these years. I was diagnosed with system lupus erythematosus and was placed under the care of an awesome rheumatologist.

Now with all that being said, lupus mainly affects women. It is thought to be partially influenced by hormonal factors. Finding this out, I started haphazardly experimenting with different compounds to lower estrogen and raise my testosterone. Enclomiphene was my first compound and I saw some pretty amazing results. At 25 mg per day for 12 weeks, I was able to lower my E2 to 20 and raise my total testosterone to around 850 if I remember correctly. This sent me down a rabbit hole of cycling on and off different SARMs and other compounds for a while and weight training hard 6 days a week. I didn't realize the importance of rest and recovery until a couple years ago when the lupus started flaring up on me and making recovery harder, sometimes overtraining and putting me down for up to 4 days. Knowing what I know now, I progress just fine doing and upper body, lower body, rest day split and taking an extra day if I need to. Listening to what my body is telling me is key. I don't lift competitively and I'm never going to step on stage for a physique competition. The only person I'm competing against is myself and how much I lifted the previous week. I had to learn to leave my ego at the door and not be so hard on myself when I fell short of the mark.

The introduction of exogenous testosterone was a game changer for me in how I felt and the progression of my disease. Even at simple TRT dosages of 140-160 mg per week was enough to put almost put a halt to my flare-ups for the past two years. It lowered my need for opioid pain medication dramatically and spiced up things between my wife and I. This shores up my belief that lupus has something to do with hormones, estrogen in particular. My current TRT protocol is 200 mg per week of test cyp, 100 mg per week of nandrolone decanoate, and 500 IUs of HCG twice weekly to maintain fertility and keep the boys plump. The deca wasn't added to my protocol until around 6 months ago, but within one month, I was almost pain free until night time when I laid down for bed. The deca has done wonders for my joint pain and I don't have a side effects from the 100 mg dose. I am now down to 5 mg of methadone daily for pain management and I feel better than I have in years, other than the occasional muscle tenderness and back pain from breaking my back in the military. I am eternally grateful for these compounds being readily available and I believe they are very underutilized in the treatment of some autoimmune disorders and diseases.

Are there any other members here that have autoimmune issues and if so, have you found your training, diet, and AAS protocol to be beneficial in slowing down or stopping the progression of your disease?

I know that was a long post, but I appreciate y'all pushing through if you read it. I am interested in your experiences and open to trying some of your tactics if you are willing to share. Thanks.

Gut health and autoimmunity are very connected. I haven't researched systemic lupus much, but a quick search shows it's connected, not surprisingly, to gut permeability and gut dysbiosis.



Keto diet is very anti-inflammatory due to the elevated presence of ketones (which can actually be bad for lupus) and the elevation of glutathione but it can be bad for the gut due to lower butyrate production and changes in the microbiome, but as you noted, it's an elimination diet, so in that regard it can be helpful. Just be careful as in the long rung it can create problems for you.

If I was you I'd focus on finding trigger foods and improving gut health via microbiome diversity and lowering gut permeability (which is another black hole of the internet). As you've mentioned bpc157, that could be a good thing to try - it helps with permeability - but there a lot of other important considerations to consider and bpc is not a magic pill.
 
Also, why did you go on TRT if you've managed to bring your levels to 800 ngdl?

*Aas lower immune function, so this is why they might have helped.
 
If I was you I'd focus on finding trigger foods and improving gut health via microbiome diversity and lowering gut permeability (which is another black hole of the internet). As you've mentioned bpc157, that could be a good thing to try - it helps with permeability - but there a lot of other important considerations to consider and bpc is not a magic pill.
My gut issues were my original reasoning behind using the BPc-157. I am not sure what kind of effect it had on repairing what I believe was leaky gut, but I haven’t had any gut issues in a few years since changing my diet and getting that back in track. I haven’t had any heartburn, upset stomach, irritable bowel type symptoms or anything like that in at least two years. I’m actually at the doctor with my wife right now getting some scans done to figure out what is wrong with her gut, so depending what is going on with her I may try to get her to give it a go.

Also, why did you go on TRT if you've managed to bring your levels to 800 ngdl?

Honestly, when I started cycling actual AASs, I got addicted to the results. I got tired of cycling on and off. I felt a lot better while I was on and I got tired of losing that feeling. I was happier, my wife was happier, and I made the decision together with her to stay on. My fertility was preserved with HCG because we are still wanting another baby. It has kept my sperm count, motility, and volume in check. Unfortunately, we have had three miscarriages the past year and half, which has been rough on both of us.
 
My gut issues were my original reasoning behind using the BPc-157. I am not sure what kind of effect it had on repairing what I believe was leaky gut, but I haven’t had any gut issues in a few years since changing my diet and getting that back in track. I haven’t had any heartburn, upset stomach, irritable bowel type symptoms or anything like that in at least two years. I’m actually at the doctor with my wife right now getting some scans done to figure out what is wrong with her gut, so depending what is going on with her I may try to get her to give it a go.



Honestly, when I started cycling actual AASs, I got addicted to the results. I got tired of cycling on and off. I felt a lot better while I was on and I got tired of losing that feeling. I was happier, my wife was happier, and I made the decision together with her to stay on. My fertility was preserved with HCG because we are still wanting another baby. It has kept my sperm count, motility, and volume in check. Unfortunately, we have had three miscarriages the past year and half, which has been rough on both of us.

I'm sorry to hear about the miscarriages. That must have been rough.

Yeah, the ON feeling - you can become reliant on it and while it becomes an integral part of your personality structure, you can loose other psychological mechanisms that otherwise kept you sane and stable. Where are your levels at with those 200 mg's?

Also, if that's you in the avi, you look bloated? Is that normal for you?
 
I'm sorry to hear about the miscarriages. That must have been rough.

Yeah, the ON feeling - you can become reliant on it and while it becomes an integral part of your personality structure, you can loose other psychological mechanisms that otherwise kept you sane and stable. Where are your levels at with those 200 mg's?

Also, if that's you in the avi, you look bloated? Is that normal for you?
With testosterone only, at .33 ml every two days, it’s around 1200 give or take. When I add the nandrolone in with it, it shoots on up to 1450 on the low end, but the past couple blood tests have been pushed out of the reference range with 100 mg of nandrolone added.
 
With testosterone only, at .33 ml every two days, it’s around 1200 give or take. When I add the nandrolone in with it, it shoots on up to 1450 on the low end, but the past couple blood tests have been pushed out of the reference range with 100 mg of nandrolone added.

That's a high androgen load to be on all year round. You still on any psych meds? Some sort of anti-inflammatory/neurogenesis promoting agent is a good idea if you want to stay healthy with prolonged aas use.
 
That's a high androgen load to be on all year round. You still on any psych meds? Some sort of anti-inflammatory/neurogenesis promoting agent is a good idea if you want to stay healthy with prolonged aas use.
No psych meds since 2019. Turns out I didn’t really need them.

Do you mind giving me some examples of the compounds you are referring to when you say “anti-inflammatory/neurogenesis promoting agent”?
 
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