MESO-Rx Exclusive Trenbolone facts - series on unique characteristics of different steroids

[IndividualMan]

all this tren ester talk makes me want to get some tren for my next cut.
maybe some enanthate, steroid plotter and grok AI is telling me that i get more out of enanthate VS ace, due to their longer half lives. : )

 

[RockyP]

eh, half true. just because elimination time is longer only really means that you reach peak concentration slower.
(steroid plotter has done irreversible damage on this communitys understanding of esters, clearance times, serum concentrations and Pharmacokinetics)

I have no idea what steroid plotter is and have never used it.

The real nuance that’s lost here is not “dosage” but the pharmacodynamic effect of these different esters. Ask yourself, how different will you feel, how different will your bloodwork be, how different will the side effects be if instead of taking 500 mg per week of test C, you took 100 mg of TNE 5x per week? It’s the same compound. Same dosage. But you’re going to be in for a much different ride on the TNE 5x weekly compared to the cyp.

 

[IndividualMan]

feel

Anything else is just for feelz.

how different will the side effects be if instead of taking 500 mg per week of test C, you took 100 mg of TNE 5x per week?

true, but unesterfied vs Ace ester is a massive difference.
unesterfied will always clear too quickly to be effective/practical. If you were to pin 12x/day tho (for stable levels), you would get the same effects as the 500 cyp tho. its just impractical, no magic ester completely changing effects.

Thats like saying "if I pin ace 1x/week and E 1x/week the E works better" no shit, exposure time is different. Nothing else

 

[RockyP]

true, but unesterfied vs Ace ester is a massive difference.
unesterfied will always clear too quickly to be effective/practical. If you were to pin 12x/day tho (for stable levels), you would get the same effects as the 500 cyp tho. its just impractical, no magic ester completely changing effects.

Thats like saying "if I pin ace 1x/week and E 1x/week the E works better" no shit, exposure time is different. Nothing else

But this ignores the impact that pulse dosing of something like TNE would have on your BP, HCT, etc. that was my point that we’re all losing the forest from the trees. The “dosage” Or steady state circulating concentration whatever we call does not necessarily Have the same physiological impact across the board. In terms of Tren ace vs the longer esters, I think what’s most important in the real world is not really the “dosage” per se but how well a person tolerates a given compound. For example, some guys metabolize acetate really fast and it’s the up and down fluctuations that give them sides. For some of us that’s not an issue at all and we prefer acetate just to be able to turn it off quickly if needed. The other issue of course is that there’s tremendous variability from person to person in terms of metabolism and clearance of these drugs, which is why careful / informed trial and error is the best approach.

Putting aside the minutiae of the ace vs long esters, IMO the most important take away is if you’re new to tren, best to start with acetate. If that goes well, just keep doing that. If you want to try hex or enan, go ahead, but try it at a lower dosage just in case it doesn’t agree with you for some reason, as you’ll be stuck with those side effects for a bit of time.

 

[Sampei]

But this ignores the impact that pulse dosing of something like TNE would have on your BP, HCT, etc. that was my point that we’re all losing the forest from the trees. The “dosage” Or steady state circulating concentration whatever we call does not necessarily Have the same physiological impact across the board. In terms of Tren ace vs the longer esters, I think what’s most important in the real world is not really the “dosage” per se but how well a person tolerates a given compound. For example, some guys metabolize acetate really fast and it’s the up and down fluctuations that give them sides. For some of us that’s not an issue at all and we prefer acetate just to be able to turn it off quickly if needed. The other issue of course is that there’s tremendous variability from person to person in terms of metabolism and clearance of these drugs, which is why careful / informed trial and error is the best approach.

Putting aside the minutiae of the ace vs long esters, IMO the most important take away is if you’re new to tren, best to start with acetate. If that goes well, just keep doing that. If you want to try hex or enan, go ahead, but try it at a lower dosage just in case it doesn’t agree with you for some reason, as you’ll be stuck with those side effects for a bit of time.

With this I can agree completely

 

[bananafeet]

Type2x has once again covered this before. I think it was about the biphasic nature of TNE and E2.

Faster esters provide more area under the curve. This means more side effects that are a result of higher acute blood concentrations.

This is obviously why hex was chosen for the human version due to its ridiculously long half life. Obviously oil type and the size of the depot has an effect as well. Ie test undecanoate using a thick oil like castor.

Anyhow the drugs act differently depending on the delivery mechanism. I'm pretty sure trens effects in the parabolan product and in cattle are from blocking catabolism thereby adding net anabolism.

That's why you hear the big guys saying they aren't really impressed with the drug from a mass gaining perspective. In a calorie surplus catabolism would be relatively low.

Still it's fun to take and the agression is addictive.

 

[xrayphoton13]

eh, half true. just because elimination time is longer only really means that you reach peak concentration slower.
(steroid plotter has done irreversible damage on this communitys understanding of esters, clearance times, serum concentrations and Pharmacokinetics)

Steroid plotter has tren hex with a shorter half life than tren e and I'm pretty sure test d with a shorter half life than test e. I think they have different half lives for all the enanthates: tren e, test e, primo e, and mast e. The source links I looked at went to crappy studies that didn't even test half life and merely stated it without any evidence.

 

[Mfras]

Whoah. So I’ve read the threads you’re talking about and my takeaway was that the enanthate is approximately 90% as strong as the acetate, but I’d pin it 2 or 3 times a week not ED or EOD. Some people seemed to count all the hormone in your body as the amount that you experience effects from but it makes much more sense that a good amount is locked up in the slow release ester. Otherwise where would the longer on and offramps come from?

I would expect the enanthate release to take a few weeks to saturate and a few weeks to leave, like longer than cypionate but not forever like decanoate. And the consensus seems to be that something like 385/week tren E would be equivalent to 350/week tren A, but anecdotal evidence is scattered, with people reporting everything from a smoother ride on E to a much bumpier one.

Personally I believe that a slightly higher dose would be necessary for the same effect if I used E instead of A, but also I would be more conservative out of respect for the compound and less ability to clear the longer ester.

For myself the jury’s still out on whether I’d do a tren cycle again, despite tolerating it well so far. But this shit is endlessly interesting separating the lore from bro science from individual tolerance and benefit.

I do appreciate the advice re: PIP and higher concentration at 200mg/ml. I am usually pretty resistant to pip and prefer higher concentrations for smaller amounts of oil, but it’s more psychological than necessary since I’m not trying to jam 3g in me a week or something.