Trizepatide tips / tricks

Is appetite suppression completely unnecessary, perhaps even a negative so should be minimized, or would some level be welcome despite being able to keep your diet on point? In other words, is there any "exertion" required to your diet efforts, giving room for some welcome relief, freeing up "willpower bandwidth" for other things, or would an impaired appetite to any degree be a problem, as it might be with someone who has to consciously eat a sufficient amount of calories or risk losing too much weight?
Yes, I suppose some appetite suppression would be beneficial for reasons you describe. I just wanted to make a distinction between someone severely overweight that needs to drastically control their diet (no offense to those people) vs my situation where I plan to use minimum doses to gain other benefits of the drug for honing my physique and health rather than drastically changing them.
 
Has anyone been able to put on a decent amount of muscle while on Trizepatide ?
Yes. Unfortunately I don't have any tangible metrics to provide but I'll give my anecdote. I started just over a year ago, completely 100% untrained and just fat fat. late 30's, 6'1" 260lbs. Moderate-heavy drinker, crappy diet, sleep apnea, gout, etc. Started tire 12/2023. Was determined to make the most of it and thankfully had some very good guidance from friends in the space.

Tirz completely obliterated my desire for alcohol. I quit cold turkey for 9 months and only recently started to have a tiny little drink here and there for social reasons but am mostly still completely uninterested.

As stated many times, protein, protein, and more protein. I try to get 180g per day on average. I use the shit out of Fairlife shakes while traveling, and mix my own with fairlife milk when home. I also hydrate a bunch and use electrolytes (Saltt or LMNT).

I was completely de-trained. Haven't lifted a weight in 20 years or done any sort of activity at all. I started walking 10k steps per day, lifting 2-3 times per week and just watched the changes happen. I wasn't originally much interested in building muscle but just didn't want to become skinny fat. I wanted to keep the weight off for good. Seeing the composition changes happen before my eyes was quite motivating. I'll never forget the first time I saw definition in my Delts or the first signs of vascularity in my forearms. Just that little motivation helped me keep the foot on the gas to where I am now, training 4-6 days a week, and actually starting to see some not totally embarrassing PR's.

The stories of "GLP's cause muscle loss" are all bullshit. STARVATION causes muscle loss. You have to use GLP's properly, and eat the right food and TRAIN. IF you do those, you will not magically lose muscle.

My maximum dose was 7.5mg every 5 days. Once I hit my GW and started seeing some plateau in my PR's, I introduced TRT levels of Test C, targeting the top of the reference range for my age.
 
The stories of "GLP's cause muscle loss" are all bullshit. STARVATION causes muscle loss. You have to use GLP's properly, and eat the right food and TRAIN. IF you do those, you will not magically lose muscle.

Thank you for sharing, it sounds like you have had quite the journey.

It will be interesting to see how my body responds to alcohol, I have a few glasses of red wine nightly before bed.
 
Metamucil doesn’t have any negative side effects I’m aware of. It’s just fiber. Same for psyllium husk caps. Never heard of Movical.


Movical is a pharma laxitive.

While as you know, psyllium husk fiber is neither a laxative or anti-diarrheal, but just makes things work correctly, replacing the fiber we should be getting in food, but don't.

Like Country said. No downsides(after a short adjustment period). It's all natural, you'll feel better, good for your health, lipids improve, you'll look forward to hitting the bathroom. It's a good habit.

Only downside, for me, I can only tolerate the Metamucil orange drink powder form (others are too gritty), and for some it's not cheap. Buy it at Costco if you can.
 
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some Diphenhydramine, sold under the brand name Benadryl, will help against being nauseous, If you have eaten too much or to greasy while on Tirzepatide ( I had to find out the hard way ) and do not forget to hydrate with plenty of electrolytes, as has been said here before
 
Why not take something like Movicol? It's extremely effective at keeping one regular, all while having virtually no side effects.
It looks like this is polyethylene glycol 3350. In the US the brand name is Miralax.

My working group has people who recommend both. Because PEG3350 is considered an irritant diuretic, the direction from (US)FDA is that it is not to be taken for more than 7 days. My primary care doctor tells me to take it every day with two doses of Metamucil. (This is also a handy doctor trick to get people to drink more fucking water.)

As a clinician, I can tell you that not all irritants are created equal. I'm sure that there is a document that shows a statistically significant elevation of IgE or some cytokine associated with the inflammatory cascade. That statistical significance does not rise to clinical significance with a frequency that warrants such a restrictive direction.

In short: Metamucil and Miralax/PEG3350/Movicol should both be on hand. I advise people to stop at the store and get a bottle of magnesium citrate drink and some bisacodyl suppositories in case the situation gets serious.

Man, I'm realizing that one reason I love the G-AR drugs is all the legitimate shit talk that we get to have.
 
It looks like this is polyethylene glycol 3350. In the US the brand name is Miralax.

My working group has people who recommend both. Because PEG3350 is considered an irritant diuretic, the direction from (US)FDA is that it is not to be taken for more than 7 days. My primary care doctor tells me to take it every day with two doses of Metamucil. (This is also a handy doctor trick to get people to drink more fucking water.)

As a clinician, I can tell you that not all irritants are created equal. I'm sure that there is a document that shows a statistically significant elevation of IgE or some cytokine associated with the inflammatory cascade. That statistical significance does not rise to clinical significance with a frequency that warrants such a restrictive direction.

In short: Metamucil and Miralax/PEG3350/Movicol should both be on hand. I advise people to stop at the store and get a bottle of magnesium citrate drink and some bisacodyl suppositories in case the situation gets serious.

Man, I'm realizing that one reason I love the G-AR drugs is all the legitimate shit talk that we get to have.
This is very informative.

I believe that Movicol differs from Miralax in that it has a bunch of minerals/sodium added to it, which apparently (based on people's experiences I read online) makes it more effective. I do not claim to know whether this is true or not, however.

Also, doctors here prescribe Movicol long term and most people seem to take it with no ill effects, but they do caution that you need to drink extra water on it. My had has been taking two doses a day for a long time; he is diabetic.
 
This is very informative.

I believe that Movicol differs from Miralax in that it has a bunch of minerals/sodium added to it, which apparently (based on people's experiences I read online) makes it more effective. I do not claim to know whether this is true or not, however.

Also, doctors here prescribe Movicol long term and most people seem to take it with no ill effects, but they do caution that you need to drink extra water on it. My had has been taking two doses a day for a long time; he is diabetic.
I was looking at that and trying to find some documentation to get up to speed. It looks like a very good product. I think it's like everything else we're doing here, in the shadow of legality... start low, slowly increase the dose until you get the effect you need, and take no more than that. Minimum effective dose is the king of doses -- and it's a moving target, like when you lose weight and may need more receptor agonist, but it's always the same process.
 
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