MESO-Rx
Anabolic Steroids
Trizepatide tips / tricks
- Thread starter runitback
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OldGHGuy
Well-known Member
Yes, I suppose some appetite suppression would be beneficial for reasons you describe. I just wanted to make a distinction between someone severely overweight that needs to drastically control their diet (no offense to those people) vs my situation where I plan to use minimum doses to gain other benefits of the drug for honing my physique and health rather than drastically changing them.
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TedStriker
New Member
Yes. Unfortunately I don't have any tangible metrics to provide but I'll give my anecdote. I started just over a year ago, completely 100% untrained and just fat fat. late 30's, 6'1" 260lbs. Moderate-heavy drinker, crappy diet, sleep apnea, gout, etc. Started tire 12/2023. Was determined to make the most of it and thankfully had some very good guidance from friends in the space.
Tirz completely obliterated my desire for alcohol. I quit cold turkey for 9 months and only recently started to have a tiny little drink here and there for social reasons but am mostly still completely uninterested.
As stated many times, protein, protein, and more protein. I try to get 180g per day on average. I use the shit out of Fairlife shakes while traveling, and mix my own with fairlife milk when home. I also hydrate a bunch and use electrolytes (Saltt or LMNT).
I was completely de-trained. Haven't lifted a weight in 20 years or done any sort of activity at all. I started walking 10k steps per day, lifting 2-3 times per week and just watched the changes happen. I wasn't originally much interested in building muscle but just didn't want to become skinny fat. I wanted to keep the weight off for good. Seeing the composition changes happen before my eyes was quite motivating. I'll never forget the first time I saw definition in my Delts or the first signs of vascularity in my forearms. Just that little motivation helped me keep the foot on the gas to where I am now, training 4-6 days a week, and actually starting to see some not totally embarrassing PR's.
The stories of "GLP's cause muscle loss" are all bullshit. STARVATION causes muscle loss. You have to use GLP's properly, and eat the right food and TRAIN. IF you do those, you will not magically lose muscle.
My maximum dose was 7.5mg every 5 days. Once I hit my GW and started seeing some plateau in my PR's, I introduced TRT levels of Test C, targeting the top of the reference range for my age.
SubparMarioBro
New Member
Thank you for sharing, it sounds like you have had quite the journey.
It will be interesting to see how my body responds to alcohol, I have a few glasses of red wine nightly before bed.
Mrhairyman
Member
Thanks for posting this thread, I feel it was long over due
Metamucil doesn’t have any negative side effects I’m aware of. It’s just fiber. Same for psyllium husk caps. Never heard of Movical.
Ghoul
Well-known Member
Movical is a pharma laxitive.
While as you know, psyllium husk fiber is neither a laxative or anti-diarrheal, but just makes things work correctly, replacing the fiber we should be getting in food, but don't.
Like Country said. No downsides(after a short adjustment period). It's all natural, you'll feel better, good for your health, lipids improve, you'll look forward to hitting the bathroom. It's a good habit.
Only downside, for me, I can only tolerate the Metamucil orange drink powder form (others are too gritty), and for some it's not cheap. Buy it at Costco if you can.
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markus holland
New Member
some Diphenhydramine, sold under the brand name Benadryl, will help against being nauseous, If you have eaten too much or to greasy while on Tirzepatide ( I had to find out the hard way ) and do not forget to hydrate with plenty of electrolytes, as has been said here before
It looks like this is polyethylene glycol 3350. In the US the brand name is Miralax.
My working group has people who recommend both. Because PEG3350 is considered an irritant diuretic, the direction from (US)FDA is that it is not to be taken for more than 7 days. My primary care doctor tells me to take it every day with two doses of Metamucil. (This is also a handy doctor trick to get people to drink more fucking water.)
As a clinician, I can tell you that not all irritants are created equal. I'm sure that there is a document that shows a statistically significant elevation of IgE or some cytokine associated with the inflammatory cascade. That statistical significance does not rise to clinical significance with a frequency that warrants such a restrictive direction.
In short: Metamucil and Miralax/PEG3350/Movicol should both be on hand. I advise people to stop at the store and get a bottle of magnesium citrate drink and some bisacodyl suppositories in case the situation gets serious.
Man, I'm realizing that one reason I love the G-AR drugs is all the legitimate shit talk that we get to have.
This is very informative.
I believe that Movicol differs from Miralax in that it has a bunch of minerals/sodium added to it, which apparently (based on people's experiences I read online) makes it more effective. I do not claim to know whether this is true or not, however.
Also, doctors here prescribe Movicol long term and most people seem to take it with no ill effects, but they do caution that you need to drink extra water on it. My had has been taking two doses a day for a long time; he is diabetic.
I was looking at that and trying to find some documentation to get up to speed. It looks like a very good product. I think it's like everything else we're doing here, in the shadow of legality... start low, slowly increase the dose until you get the effect you need, and take no more than that. Minimum effective dose is the king of doses -- and it's a moving target, like when you lose weight and may need more receptor agonist, but it's always the same process.
True. It really is!
Movicol isn't really prescribed as a "laxative" here; it's a stool softener; it draws water to your intestines (hence why you need to drink lots of water on it, or you'll dry out too much) to form mass and get things moving. This drug alone saved me when I had hemorrhoids not long ago (it makes you poop ice cream). That said, you will be more regular as a result, but regularity will be more "natural", as opposed to a real laxative. I really like it, and NEVER had to increase the dose (1 packet), no matter how long I took it.
I also believe Justin Harris has his guy use it during prep to ensure they're fully emptied out to avoid distention.
mikeh1998
New Member
I feel like my maintenance dose of 2.5 mg Tirzepatide is too high. Trying to gain weight slowly now that I have gone down from about 203 lb to 183 lb. Really struggling to get meals in at this point.
I thought about dropping Tirzepatide altogether but I don't think it's a great idea because of immunogenicity fears (don't want to stop start stop start over and over) and I would still get the other benefits by continuing it.
Just want a sanity check, correct course of action here is to lower the dose further right? 1.25 mg? Or do you guys completely drop Tirz once you lost the fat?
Would it make sense for me to run 1.25 mg Tirzepatide and then maybe some appetite stimulator like GHRP-6 as needed 1-3x per day?
I thought about dropping Tirzepatide altogether but I don't think it's a great idea because of immunogenicity fears (don't want to stop start stop start over and over) and I would still get the other benefits by continuing it.
Just want a sanity check, correct course of action here is to lower the dose further right? 1.25 mg? Or do you guys completely drop Tirz once you lost the fat?
Would it make sense for me to run 1.25 mg Tirzepatide and then maybe some appetite stimulator like GHRP-6 as needed 1-3x per day?
Ghoul
Well-known Member
Drop the dose to maintain "continuous exposure" if the appetite suppression is interfering with your ability to eat enough.
Expect it to take 2 weeks to experience the majority of effects of the new level, 4 for it to fully manifest.
Anonymous35
New Member
The problem with those studies who concludes that glp 1 can make you lose muscle
The reality it’s just way harder in term of appetite to eat a lot of protein especially meat with it
And you desire to eat some meat isn’t really there
That’s probably why they lost muscles at the end
They probably didn’t workout and didn’t eat any protein at all due to the fact they are way harder to Digest (protein)
The reality it’s just way harder in term of appetite to eat a lot of protein especially meat with it
And you desire to eat some meat isn’t really there
That’s probably why they lost muscles at the end
They probably didn’t workout and didn’t eat any protein at all due to the fact they are way harder to Digest (protein)
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