MESO-Rx
Anabolic Steroids
Update on statins
- Thread starter 120nmol
- Start date
Wow thats great! Thank you for sharing.
guyfawkes1010
Member
Damn wish my lipids got that much better taking lipitor 10mg. Barely did anything and was giving me sides I think.
trajtemberg
New Member
Great report. Thanks for sharing it.
egruberman
Well-known Member
You could drop the dose even more and pair it with ezetimibe and bempedoic acid which stack nicely and will tank your LDL I wager.
Make sure you take them at Bedtime
Will be dramatic
There are very few "free lunches" in this PED/sup game. Seven that I know/use that are absolutes for me are:
1) Creatine - strength/recovery
2) Low dose Statins - destroys cholesterol (take at bedtime)
3) Tadalafil 2.5 - 5 mg - prostate/pumps/hard-ons
4) Turmeric - Inflammation
5) Beets - energy/pumps/pre-workout
6) Whey protein - well known
7) Caffeine - in moderation/pre-workout/fat burn/energy
1) Creatine - strength/recovery
2) Low dose Statins - destroys cholesterol (take at bedtime)
3) Tadalafil 2.5 - 5 mg - prostate/pumps/hard-ons
4) Turmeric - Inflammation
5) Beets - energy/pumps/pre-workout
6) Whey protein - well known
7) Caffeine - in moderation/pre-workout/fat burn/energy
Vanargandar
Well-known Member
I've seen this said several times; what's the thought process behind taking a statin at bedtime?
I just want to clarify, I know why people are saying it, but I want to see why it keeps getting stated as a matter of fact.
BP_6
New Member
It's because the liver, which produces a large amount of cholesterol, does so primarily when you are sleeping. However with rosuvastatin, it doesn't matter as much as with the other statins as it has a much longer half life. I still take my low dose at night anyway though.
Vanargandar
Well-known Member
IIRC, it's also due to taking the shorter acting statins during the lowest consumption of food, in combination with what you mentioned.
But yes, correct, with newer/longer acting statins (re: rosuvastatin), time is mostly irrelevant.
Also; if that's you in your PFP, you're insane bro.
egruberman
Well-known Member
Half life of rosuvastatin is 19 hours. Doesn't really matter when it's taken if it's taken daily.
Add psyllium husks to that list above.
Add psyllium husks to that list above.
This explains it well. But it is true that it depends on which statin one is taking:
When Is the Best Time of Day to Take Atorvastatin: Morning or Night?
The recommended time for taking statins can vary depending on the type you’re prescribed. Learn more about whether it matters if you take atorvastatin in the morning or at night and the dosage timing for other types of statins.
update nov/2024
Diet - carnivore
Duration - 7 months
300g fat
300g protein
0 carbs
(Animal based)
PEDs
testosterone 175mg
Oral DHT - 175mg
Npp - 70mg
T4 - 100mcg a day
Hgh - 6iu a day split
No lipid control
Bloods were taken after 7 months of this protocol
Results
Diet - carnivore
Duration - 7 months
300g fat
300g protein
0 carbs
(Animal based)
PEDs
testosterone 175mg
Oral DHT - 175mg
Npp - 70mg
T4 - 100mcg a day
Hgh - 6iu a day split
No lipid control
Bloods were taken after 7 months of this protocol
Results
24 hours after blood result I started lipid control
Meds
Ezetimbe 10mg
Rosuvastatin 10mg
Daily
Results after 3 weeks
Same peds same diet
conclusion
Lipid profile is easily fixed when needed
Damage that was done
Tested cpk after 2 weeks with no statin only ezitmbe 10mg daily
Currently 3 months only using ezitmbe 10mg daily same carnivore diet
Lipid panel came back at …
Cholesterol 200
Hdl 35
LDL 120
Triglycerides 50
Can’t be bothered logging in to the health care app for the results/taking the pics
Also did mri and full heart eco and calcium score .. I’m all good nothing to worry about
Will continue eztimbe for now will see if I’ll change diet or not if there will be more updates regarding this topic I’ll let you guys know
Meds
Ezetimbe 10mg
Rosuvastatin 10mg
Daily
Results after 3 weeks
Same peds same diet
conclusion
Lipid profile is easily fixed when needed
Damage that was done
Tested cpk after 2 weeks with no statin only ezitmbe 10mg daily
Currently 3 months only using ezitmbe 10mg daily same carnivore diet
Lipid panel came back at …
Cholesterol 200
Hdl 35
LDL 120
Triglycerides 50
Can’t be bothered logging in to the health care app for the results/taking the pics
Also did mri and full heart eco and calcium score .. I’m all good nothing to worry about
Will continue eztimbe for now will see if I’ll change diet or not if there will be more updates regarding this topic I’ll let you guys know
Attachments
DugPrime
Member
Man, you shouldn't use 10mg of Ezetimibe, but 5mg.
Ezetimibe 5 and 10 mg for lowering LDL-C: potential billion-dollar savings with improved tolerability - PubMed
These data strongly suggest that ezetimibe 5 mg and ezetimibe 10 mg are clinically equivalent with respect to LDL-C reduction and achievement of ATP III LDL-C goals. Widespread adoption of this low-dose strategy could result in a potential cost savings of more than a billion dollars annually...
pubmed.ncbi.nlm.nih.gov
" These data strongly suggest that ezetimibe 5 mg and ezetimibe 10 mg are clinically equivalent with respect to LDL-C reduction and achievement of ATP III LDL-C goals. Widespread adoption of this low-dose strategy could result in a potential cost savings of more than a billion dollars annually... "
First of all these are some fascinating results - thank you for posting. It seems like you may fall into the "lean mass hyper responder" category, which is not supposed to be associated with the same negative CVD outcomes that would accompany cholesterol that was similarly high due to different causes.
How does ezetimibe affect your digestion on a carnivore diet? I also eat an almost-carnivore diet and was concerned to read that ezetimibe interferes with digestion and absorption of fat. Any new diarrhea or other signs of malabsorption?
BP_6
New Member
It doesn't affect fat absorption. Just cholesterol absorption and is a very low side effect drug. I take 10mg with 5mg crestor ED.
It does in mice:
Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1−/− mice - PMC
The impact of NPC1L1 and ezetimibe on cholesterol absorption are well documented. However, their potential consequences relative to absorption and metabolism of other nutrients have been only minimally investigated. Thus studies were undertaken to ...
pmc.ncbi.nlm.nih.gov
BP_6
New Member
Well, if it did to any real tangible extent, you would get oily stool like you do with orlistat. Never gotten that even with higher fat meals nor have I heard of anyone getting that side. Like I said, it is a very low side effect drug.It does in mice:
Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1−/− mice - PMC
The impact of NPC1L1 and ezetimibe on cholesterol absorption are well documented. However, their potential consequences relative to absorption and metabolism of other nutrients have been only minimally investigated. Thus studies were undertaken to ...
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