anabolicmanx19
New Member
Hello everyone
i spent last month reading a lot of studies about harmful effect of anabolic steroids in body organs , especially with these that related to the brain
because that the one thing that you can't really monitor especially in the long term
so i discovered some interesting things and almost none of them is known ( some are based on new studies and some are based on old studies ) and some are good news and some are bad news
first of all , none of these claims are bro science or personal opinion , all are the information here are based on objective studies
1 - Here is A big study published in 2022 compare between the famous 4 anabolic steroids ( stanzolol,tren,deca,test) , and their effect on the brain and body organs
Anabolic Androgenic Steroids: Neurobiological Effects of Nandrolone, Testosterone, Trenbolone, and Stanozolol
so what was the worst one for body organs, for the brain ? its was Deca
here from the abstract of the study , then will go into details :
In addition, nandrolone decanoate caused a reduced general activity, an effect possibly induced by increased stress vulnerability and alterations in the oxytocinergic system. Furthermore, nandrolone decanoate induced impaired memory in the novel object recognition test. Overall, nandrolone decanoate was identified as the most harmful steroid investigated due to its prominent impact on body weight development, affecting multiple organs, and being the only AAS causing impaired cognitive function.
and here are the details and the most important things from the full study ( you have to download it to see the full study )
First thing about body organs and comparing between test,deca,tren and their harmful effect on internal organs Liver,Thymus,Kidney,Testis
As you see the worst for Kidney and liver was Deca
highest increasing of the weight of the kidney was caused by nandrolone decanoate then was tren (which indicate renal toxicant)
also deca was the worst on the liver because it reduced the weight of the liver (which indicate liver damage ) although hepatic alterations are primarily associated with 17a-alkylated aas
so what about the brain cells, and brain function ? which one is the worst ?
Deca also was the worst for brain cells , and brain function
tren actually in this study not impaired cognitive function at all , even this amazed the researchers
The results obtained are in line with previous published findings, where nandrolone decanoate has been described to impair memory in other types of memory tests. For example, both spatial memory function in the Morris water maze task (Magnusson et al., 2009, Pieretti et al., 2013, Tanehkar et al., 2013), as well as olfactory social memory (Kouvelas et al., 2008) are reported to be altered following nandrolone decanoate treatment. Testosterone, on the other hand, has previously been described not to affect memory (Clark et al., 1995, Wood and Serpa, 2020), which also is in accordance with the results from paper IV. Surprisingly, trenbolone decanoate did not induce an impairment in the NOR-test. Trenbolone display several pharmacological similarities with nandrolone decanoate, including the ability to cause neurodegeneration (Ma and Liu, 2015). Furthermore, trenbolone has been described by AAS-users to cause particular harm (Scarth and Bjørnebekk, 2021). In our studies, trenbolone however did not have an impact on cognitive function.
so what about the brain cells ? also deca was the worst , this based in 2019 study that also the previous study quoted it
the study was comparing the effect of stan,test,deca,tren and their effect on neuronal cortical cell (neurons)
And here the conclusion of the study : With respect to the parameters assessed, nandrolone appeared to be the most toxic AAS, while testosterone, stanozolol, and trenbolone disposed similar effects but to a lesser extent. According to the present results, the order of the examined AASs regarding their toxicity was found to be nandrolone > trenbolone > testosterone > stanozolol.
So the big question here what about the amyloid plaque study with tren ? what about it ?
first of all
how many of you guys know that supraphysiologic doses of testosterone also increase Aβ levels ? Source
also dianabol and deca increase neuronal susceptibility to the apoptotic stimulus provided by Aβ Source ( which is worse than accumulation of the plaque )
and regardless of other neurotoxic effects of alcohol and smoking on the cns
smoking also accumulate amyloid plaques (Aβ42,Aβ40) in the hippocampus and cortex in the brain of humans and animals )
ٍSources :
1,2,3,4,5
even moderate amount of alcohol also accumulate amyloid plaques in the brain 1,2
never seen anyone before cites these studies like we see with tren amyloid study (regardless it was a single study with poor methodology )
the most important thing now ? is amyloid plaque cause alzheimer's ? in the peds community there is a few people know amyloid hypothesis "amyloid cause alzheimer's " debunked and falsified in a lot of studies , the whole amyloid hypothesis was scandal Source , even the drugs that targets the plaques has failed to show any cognitive benefits even it worsen the patients 1,2,https://www.reuters.com/business/healthcare-pharmaceuticals/roche-shutters-most-trials-alzheimers-drug-after-failed-trials-2022-12-01/ (3) , and the frequent presence of amyloid plaques in the brains of cognitively healthy older people even without a single neurological problem 1,2,3 .
also the hypothesis has been completely falsified in the recent studies
1,2,3,4,5,6
so its clear now that there is no causation between amyloid plaques and alzheimer's ,
only poor correlation that explains a very little to us so far
also one last thing there is 2022 study linked supraphysiological doses of deca and test to cause neuronal degeneration in locus coeruleus ( the main noradrenergic nucleus of the brain ) and the degeneration of neurons in the locus coeruleus has been postulated as a contributor to the development of neurodegenerative diseases such as alzheimer's disease and parkinson's disease Source
no one is talking about this study , and this study is worse than the tren fake hypothesis study , but because its not about demonizing tren
so no one will care
professional bodybuilders uses tons of peds throughout their lives ( including tren and what more alot worse than tren ) none of them developed dementia and alot of them in their 60s and 70s now
so be aware of the demonizing propaganda that targeting peds
sorry for my weird english , not my primary language
stay safe guys
i spent last month reading a lot of studies about harmful effect of anabolic steroids in body organs , especially with these that related to the brain
because that the one thing that you can't really monitor especially in the long term
so i discovered some interesting things and almost none of them is known ( some are based on new studies and some are based on old studies ) and some are good news and some are bad news
first of all , none of these claims are bro science or personal opinion , all are the information here are based on objective studies
1 - Here is A big study published in 2022 compare between the famous 4 anabolic steroids ( stanzolol,tren,deca,test) , and their effect on the brain and body organs
Anabolic Androgenic Steroids: Neurobiological Effects of Nandrolone, Testosterone, Trenbolone, and Stanozolol
so what was the worst one for body organs, for the brain ? its was Deca
here from the abstract of the study , then will go into details :
In addition, nandrolone decanoate caused a reduced general activity, an effect possibly induced by increased stress vulnerability and alterations in the oxytocinergic system. Furthermore, nandrolone decanoate induced impaired memory in the novel object recognition test. Overall, nandrolone decanoate was identified as the most harmful steroid investigated due to its prominent impact on body weight development, affecting multiple organs, and being the only AAS causing impaired cognitive function.
and here are the details and the most important things from the full study ( you have to download it to see the full study )
First thing about body organs and comparing between test,deca,tren and their harmful effect on internal organs Liver,Thymus,Kidney,Testis
As you see the worst for Kidney and liver was Deca
highest increasing of the weight of the kidney was caused by nandrolone decanoate then was tren (which indicate renal toxicant)
also deca was the worst on the liver because it reduced the weight of the liver (which indicate liver damage ) although hepatic alterations are primarily associated with 17a-alkylated aas
so what about the brain cells, and brain function ? which one is the worst ?
Deca also was the worst for brain cells , and brain function
tren actually in this study not impaired cognitive function at all , even this amazed the researchers
The results obtained are in line with previous published findings, where nandrolone decanoate has been described to impair memory in other types of memory tests. For example, both spatial memory function in the Morris water maze task (Magnusson et al., 2009, Pieretti et al., 2013, Tanehkar et al., 2013), as well as olfactory social memory (Kouvelas et al., 2008) are reported to be altered following nandrolone decanoate treatment. Testosterone, on the other hand, has previously been described not to affect memory (Clark et al., 1995, Wood and Serpa, 2020), which also is in accordance with the results from paper IV. Surprisingly, trenbolone decanoate did not induce an impairment in the NOR-test. Trenbolone display several pharmacological similarities with nandrolone decanoate, including the ability to cause neurodegeneration (Ma and Liu, 2015). Furthermore, trenbolone has been described by AAS-users to cause particular harm (Scarth and Bjørnebekk, 2021). In our studies, trenbolone however did not have an impact on cognitive function.
so what about the brain cells ? also deca was the worst , this based in 2019 study that also the previous study quoted it
the study was comparing the effect of stan,test,deca,tren and their effect on neuronal cortical cell (neurons)
Toxic Impact of Anabolic Androgenic Steroids in Primary Rat Cortical Cell Cultures
And here the conclusion of the study : With respect to the parameters assessed, nandrolone appeared to be the most toxic AAS, while testosterone, stanozolol, and trenbolone disposed similar effects but to a lesser extent. According to the present results, the order of the examined AASs regarding their toxicity was found to be nandrolone > trenbolone > testosterone > stanozolol.
So the big question here what about the amyloid plaque study with tren ? what about it ?
first of all
how many of you guys know that supraphysiologic doses of testosterone also increase Aβ levels ? Source
also dianabol and deca increase neuronal susceptibility to the apoptotic stimulus provided by Aβ Source ( which is worse than accumulation of the plaque )
and regardless of other neurotoxic effects of alcohol and smoking on the cns
smoking also accumulate amyloid plaques (Aβ42,Aβ40) in the hippocampus and cortex in the brain of humans and animals )
ٍSources :
1,2,3,4,5
even moderate amount of alcohol also accumulate amyloid plaques in the brain 1,2
never seen anyone before cites these studies like we see with tren amyloid study (regardless it was a single study with poor methodology )
the most important thing now ? is amyloid plaque cause alzheimer's ? in the peds community there is a few people know amyloid hypothesis "amyloid cause alzheimer's " debunked and falsified in a lot of studies , the whole amyloid hypothesis was scandal Source , even the drugs that targets the plaques has failed to show any cognitive benefits even it worsen the patients 1,2,https://www.reuters.com/business/healthcare-pharmaceuticals/roche-shutters-most-trials-alzheimers-drug-after-failed-trials-2022-12-01/ (3) , and the frequent presence of amyloid plaques in the brains of cognitively healthy older people even without a single neurological problem 1,2,3 .
also the hypothesis has been completely falsified in the recent studies
1,2,3,4,5,6
so its clear now that there is no causation between amyloid plaques and alzheimer's ,
only poor correlation that explains a very little to us so far
also one last thing there is 2022 study linked supraphysiological doses of deca and test to cause neuronal degeneration in locus coeruleus ( the main noradrenergic nucleus of the brain ) and the degeneration of neurons in the locus coeruleus has been postulated as a contributor to the development of neurodegenerative diseases such as alzheimer's disease and parkinson's disease Source
no one is talking about this study , and this study is worse than the tren fake hypothesis study , but because its not about demonizing tren
so no one will care
professional bodybuilders uses tons of peds throughout their lives ( including tren and what more alot worse than tren ) none of them developed dementia and alot of them in their 60s and 70s now
so be aware of the demonizing propaganda that targeting peds
sorry for my weird english , not my primary language
stay safe guys
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