very important topic , most harmful steroid to body organs , and the most toxic to the brain ? not tren (SCIENCE BACKED)

anabolicmanx19

New Member
Hello everyone
i spent last month reading a lot of studies about harmful effect of anabolic steroids in body organs , especially with these that related to the brain
because that the one thing that you can't really monitor especially in the long term

so i discovered some interesting things and almost none of them is known ( some are based on new studies and some are based on old studies ) and some are good news and some are bad news

first of all , none of these claims are bro science or personal opinion , all are the information here are based on objective studies

1 - Here is A big study published in 2022 compare between the famous 4 anabolic steroids ( stanzolol,tren,deca,test) , and their effect on the brain and body organs

Anabolic Androgenic Steroids: Neurobiological Effects of Nandrolone, Testosterone, Trenbolone, and Stanozolol

so what was the worst one for body organs, for the brain ? its was Deca
here from the abstract of the study , then will go into details :


In addition, nandrolone decanoate caused a reduced general activity, an effect possibly induced by increased stress vulnerability and alterations in the oxytocinergic system. Furthermore, nandrolone decanoate induced impaired memory in the novel object recognition test. Overall, nandrolone decanoate was identified as the most harmful steroid investigated due to its prominent impact on body weight development, affecting multiple organs, and being the only AAS causing impaired cognitive function.

and here are the details and the most important things from the full study ( you have to download it to see the full study )

First thing about body organs and comparing between test,deca,tren and their harmful effect on internal organs Liver,Thymus,Kidney,Testis


Capture.PNG

As you see the worst for Kidney and liver was Deca

highest increasing of the weight of the kidney was caused by nandrolone decanoate then was tren (which indicate renal toxicant)

also deca was the worst on the liver because it reduced the weight of the liver (which indicate liver damage ) although hepatic alterations are primarily associated with 17a-alkylated aas

so what about the brain cells, and brain function ? which one is the worst ?

Deca also was the worst for brain cells , and brain function

tren actually in this study not impaired cognitive function at all , even this amazed the researchers

The results obtained are in line with previous published findings, where nandrolone decanoate has been described to impair memory in other types of memory tests. For example, both spatial memory function in the Morris water maze task (Magnusson et al., 2009, Pieretti et al., 2013, Tanehkar et al., 2013), as well as olfactory social memory (Kouvelas et al., 2008) are reported to be altered following nandrolone decanoate treatment. Testosterone, on the other hand, has previously been described not to affect memory (Clark et al., 1995, Wood and Serpa, 2020), which also is in accordance with the results from paper IV. Surprisingly, trenbolone decanoate did not induce an impairment in the NOR-test. Trenbolone display several pharmacological similarities with nandrolone decanoate, including the ability to cause neurodegeneration (Ma and Liu, 2015). Furthermore, trenbolone has been described by AAS-users to cause particular harm (Scarth and Bjørnebekk, 2021). In our studies, trenbolone however did not have an impact on cognitive function.

so what about the brain cells ? also deca was the worst , this based in 2019 study that also the previous study quoted it

the study was comparing the effect of stan,test,deca,tren and their effect on neuronal cortical cell (neurons)

Toxic Impact of Anabolic Androgenic Steroids in Primary Rat Cortical Cell Cultures


And here the conclusion of the study : With respect to the parameters assessed, nandrolone appeared to be the most toxic AAS, while testosterone, stanozolol, and trenbolone disposed similar effects but to a lesser extent. According to the present results, the order of the examined AASs regarding their toxicity was found to be nandrolone > trenbolone > testosterone > stanozolol.

So the big question here what about the amyloid plaque study with tren ? what about it ?

first of all

how many of you guys know that supraphysiologic doses of testosterone also increase Aβ levels ? Source

also dianabol and deca increase neuronal susceptibility to the apoptotic stimulus provided by Aβ Source ( which is worse than accumulation of the plaque )

and regardless of other neurotoxic effects of alcohol and smoking on the cns

smoking also accumulate amyloid plaques (Aβ42,Aβ40) in the hippocampus and cortex in the brain of humans and animals )

ٍSources :

1,2,3,4,5

even moderate amount of alcohol also accumulate amyloid plaques in the brain 1,2


never seen anyone before cites these studies like we see with tren amyloid study (regardless it was a single study with poor methodology )

the most important thing now ? is amyloid plaque cause alzheimer's ? in the peds community there is a few people know amyloid hypothesis "amyloid cause alzheimer's " debunked and falsified in a lot of studies , the whole amyloid hypothesis was scandal Source , even the drugs that targets the plaques has failed to show any cognitive benefits even it worsen the patients 1,2,3 , and the frequent presence of amyloid plaques in the brains of cognitively healthy older people even without a single neurological problem 1,2,3 .

also the hypothesis has been completely falsified in the recent studies
1,2,3,4,5,6

so its clear now that there is no causation between amyloid plaques and alzheimer's ,

only poor correlation that explains a very little to us so far

also one last thing there is 2022 study linked supraphysiological doses of deca and test to cause neuronal degeneration in locus coeruleus ( the main noradrenergic nucleus of the brain ) and the degeneration of neurons in the locus coeruleus has been postulated as a contributor to the development of neurodegenerative diseases such as alzheimer's disease and parkinson's disease Source

no one is talking about this study , and this study is worse than the tren fake hypothesis study , but because its not about demonizing tren
so no one will care

professional bodybuilders uses tons of peds throughout their lives ( including tren and what more alot worse than tren ) none of them developed dementia and alot of them in their 60s and 70s now

so be aware of the demonizing propaganda that targeting peds

sorry for my weird english , not my primary language

stay safe guys















 
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OOOOOOO JEEEEEZUS

How did I know you'd say Deca?

Because it's the AAS that is the focus of research into cognitive/neurological effects of androgens, taken as the model compound.

There's not enough data to rank order AAS on a continuum of least to most harmful in this regard when we hardly know what occurs.

I've written about how nandrolone, but not testosterone, increases dopamine metabolism (i.e., net breakdown) here:


Basically, androgens reduce spatial but not verbal/logical intelligence. Nandrolone decreases motivation & hinders learning (by its effects on dopamine that are probably modulated by a reduced dopamine receptor #). Yada, yada, some other data that is conflictory.

That's all we know.
 
Meso is a harm reduction forum. You believe that the compound that you deem most harmful should be banned from being discussed?
Well we had two people yesterday saying it was safe and the best weight loss supplement, so if that’s harm reduction then yes it should be banned from discussion

Because 1) it’s not safe 2) it’s not the best weight loss supplement
 
OOOOOOO JEEEEEZUS

How did I know you'd say Deca?

Because it's the AAS that is the focus of research into cognitive/neurological effects of androgens, taken as the model compound.

There's not enough data to rank order AAS on a continuum of least to most harmful in this regard when we hardly know what occurs.

I've written about how nandrolone, but not testosterone, increases dopamine metabolism (i.e., net breakdown) here:


Basically, androgens reduce spatial but not verbal/logical intelligence. Nandrolone decreases motivation & hinders learning (by its effects on dopamine that are probably modulated by a reduced dopamine receptor #). Yada, yada, some other data that is conflictory.

That's all we know.
thank you for you reply

in fact there are few studies comparing different aas and their toxicity
like those i quoted here
they compare between stan,test,tren,deca
and i just summarize what they found
 
maybe we have different definitions of harm reduction. But promotion of DNP is the last thing that reminds me of harm reduction
why would anyone try this sh!t ? there are many safer options and will give you the same results , even diet and cardio only can give you the same results
 
thank you for you reply

in fact there are few studies comparing different aas and their toxicity
like those i quoted here
they compare between stan,test,tren,deca
and i just summarize what they found
So you did.

I have to admit that since @PeterBond has practically absconded (we need him!), I've been more knee-jerk & less discerning in my initial readings of posts like this. I assume you're an idiot off the bat. I basically like idiots when we're just talking bullshit; more fun & generally funny. But when you post about topics of fact or within the scope of scientific research on Meso, I am initially skeptical.

The Abstract indicates an interesting question/hypothesis. Not sure the model is applicable, generally, to man.

But I'll have a read.
 
.

Since the law changed in 2023, this is now considered a place to buy explosives manufacturing ingredients. That’s probably the biggest reason it should not be allowed for discussion, but if that wasn’t the law then I guess “morally” allowed for discussion would be debatable. When you see people promoting it, then you have to decide mortally if that’s real harm reduction or fake harm reduction
 
.


Since the law changed in 2023, this is now considered a place to buy explosives manufacturing ingredients. That’s probably the biggest reason it should not be allowed for discussion, but if that wasn’t the law then I guess “morally” allowed for discussion would be debatable. When you see people promoting it, then you have to decide mortally if that’s real harm reduction or fake harm reduction
You know as well as I do the broad swath of these types of materials and what type of idiots have access to them for farming or construction.

But I think this poster is a bit over the top hysterical with his fear-mongering since the majority of nandrolone users barely notice anything cognitively.
 
So you did.

I have to admit that since @PeterBond has practically absconded (we need him!), I've been more knee-jerk & less discerning in my initial readings of posts like this. I assume you're an idiot off the bat. I basically like idiots when we're just talking bullshit; more fun & generally funny. But when you post about topics of fact or within the scope of scientific research on Meso, I am initially skeptical.

The Abstract indicates an interesting question/hypothesis. Not sure the model is applicable, generally, to man.

But I'll have a read.
thank you man for your reply
i hope you have the time to read , check sources
and then give me your opinion
 
You know as well as I do the broad swath of these types of materials and what type of idiots have access to them for farming or construction.

But I think this poster is a bit over the top hysterical with his fear-mongering since the majority of nandrolone users barely notice anything cognitively.
you are right man , and its impossible to say how a certain ped can effect your body and organs either in a positive way or a bad way everybody is different

but unfortunately the long term usage of aas can impair cognition
and this happen with any use of any ped , even test is toxic to the brain in supraphysiological dosage
 
You know as well as I do the broad swath of these types of materials and what type of idiots have access to them for farming or construction.

But I think this poster is a bit over the top hysterical with his fear-mongering since the majority of nandrolone users barely notice anything cognitively.

Perhaps I should rephrase my previous sentences.

“Promotion(not discussion) of DNP should be banned immediately”
 
.


Since the law changed in 2023, this is now considered a place to buy explosives manufacturing ingredients. That’s probably the biggest reason it should not be allowed for discussion, but if that wasn’t the law then I guess “morally” allowed for discussion would be debatable. When you see people promoting it, then you have to decide mortally if that’s real harm reduction or fake harm reduction
yes you are right
but i don't understand why anyone will choose to use this poison ?
you can even just do diet without cardio and this will burn the fat
why do I put myself into a danger like this to just shred some fat ?
 
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