What’s the current state of generic GH

[bjjgear]

I don’t get how people can wear slides for very long. I have a pair I use to visit the hot tub or sauna on my deck and they just don’t feel right. Like they’re constantly about to fall off.

Man I even take long (2 mile) walks in mine, I’ve been looking at the Hoka Recovery sandals and those look nice. I also wouldn’t mind going back to Birkenstocks.

I just got back from my hot tub . Life is good.

 

[bjjgear]

I truly wish getting high didn’t make me so fucking anxious and paranoid. There are aspects of it I really like. Maybe I just need to face my demons.

see i was confused,,,, I took to big a " dab" earlier haha i don't usually smoke this early in the day,,,,

 

[egruberman]

I truly wish getting high didn’t make me so fucking anxious and paranoid. There are aspects of it I really like. Maybe I just need to face my demons.

Anything beyond trace amounts of THC is a terrible experience for me. CBD is just fine. If I’m going into a large and potentially contentious meeting or some such I have a huge dose and a big can of Red Bull or something. I’m still aggressive, but the CBD keeps me from losing my calm. Gonna throw propranolol into that mix the mix chance I get.

Other than THC other recreational drugs land just fine.

 

[egruberman]

going back to Birkenstocks

You don’t smell like patchouli, do you?

 

[benfrankparkway]

I will be filtering all my peptides from here out after reading the sources you’ve posted about it. I will even be filtering stuff from a compounding pharma, not just ugl as the information about aggregation has been that convincing and alarming to me. Thank you for sharing that information. I honestly think it’s likely some of the more important harm reduction shared for peptide users since I joined meso. I am currently shopping around for some good pes .22um filters and some vials.

there should be a sticky post on how to filter. I have never did this before but reading up on it now.

 

[Toaster]

It's funny, I almost didn't bother posting about immunogenicity here, but I was reminded of the existence of "private testing groups" yesterday, and how much they irritate me.

I get it, you put in time and resources to have Jano do some comprehensive testing of one sort or another. The payoff from that is you get your specific questions answered, on your terms. But to then keep the results private, for no reason other than you can, strikes me as the worst kind of selfishness. There's simply nothing to gain from that, other than being able to hoard knowledge in order to stroke your ego.

What I share here isn't to preach (maybe a gentle "sell" of what I see as harm reduction), but I could save myself the trouble. I can handle a good faith disagreement, hell, I welcome it, but to straight up spit in my face in response to sharing what I've discovered is such uncalled for low class behavior that it can't go unresponded to.

I think you post good information and pose good questions, but you believe you're an expert when you're not.

It's good to raise awareness, but you shouldn't bias the information to make it say what you want it to say.

In the post I quoted you specifically chose those pharma brands and left off others to attempt prove what you believe the data says.

For example, why didn't you include Serostim?

 

[readalot]

Good summary of all excipients and even small section on aggregation. We know the role of each excipient in there.

New insight into the importance of formulation variables on parenteral growth hormone preparations: potential effect on the injection-site pain - PMC

Reducing injection-site pain (ISP) in patients with chronic conditions such as growth hormone deficiency is a valuable strategy to improve patient compliance and therapeutic efficiency. Thus understanding different aspects of pain induction ...

pmc.ncbi.nlm.nih.gov

See Table 3. Comprehensive.

Yawn. At least a few read it I hope.

Keep it up @Ghoul. But it is an uphill battle.

 

[readalot]

Serostim

Table 3. Post 87.

 

[malfeasance]

Yawn. At least a few read it I hope.

Keep it up @Ghoul. But it is an uphill battle.

Serostim 6mg vials are preservative free

 

[readalot]

Serostim 6mg vials are preservative free

New insight into the importance of formulation variables on parenteral growth hormone preparations: potential effect on the injection-site pain - PMC

Reducing injection-site pain (ISP) in patients with chronic conditions such as growth hormone deficiency is a valuable strategy to improve patient compliance and therapeutic efficiency. Thus understanding different aspects of pain induction ...

pmc.ncbi.nlm.nih.gov

 

[malfeasance]

New insight into the importance of formulation variables on parenteral growth hormone preparations: potential effect on the injection-site pain - PMC

Reducing injection-site pain (ISP) in patients with chronic conditions such as growth hormone deficiency is a valuable strategy to improve patient compliance and therapeutic efficiency. Thus understanding different aspects of pain induction ...

pmc.ncbi.nlm.nih.gov

That's the one in your post I was quoting (not sure why it did not show up), Table 3

 

[MA11]

there should be a sticky post on how to filter. I have never did this before but reading up on it now.

Absolutely. I thought the same while browsing filters and syringes.

Something like a 'best practice' for peptides. BAC water, dilution, filters, when to discard, IM vs SC, etc.

If I only knew who could do that...

 

[Ghoul]

Serostim 6mg vials are preservative free

And instructed to be disposed of immediately after reconstitution and administration of a single dose.



The 4mg vial is ok for 14 days refrigerated after reconstitution with BAC.

I think it's reasonable to deduce that the simple formulation of Serostim degrades too much after 14 days to support the use of the 5mg and 6mg vials for multi dose purposes.

Other brands with more anti-degradation. excipients are good for 28 days.

Most importantly Serostim includes phosphoric acid as a PH modifier to ensure it's in the correct PH solution. which seems to be the number one factor influencing aggregate formation, and degradation in general (I'll post an interesting reference in another post, that outlines the development process of long lasting pre-reconstituted HGH cartridges from Serostim).

So if there's one excipient in our wish list for UGL, it might be phosphoric acid (which also presumes a specific dilution ratio and proper BAC). The precise ratios used in Serostim are publically available. Should be easy work for a chemist.

The ideal PH is 5.8-6.2. Outside of this range degradation of HGH speeds up quite a bit.

 

[Toaster]

The post I originally quoted meant to draw conclusions that all pharma GH use sophisticated excipients, thus this differentiates it from UGL (QSC in this example) and necessitates the need for filtering.

While there are snippets of truth in that, Serostim and QSC are much closer than your post would have led someone to believe. There is also no recommendation to filter Serostim and it's good for up to 14 days.

Yes, this can lead us to make the assumption that QSC or UGLs may benefit from using phosphoric acid. We can't definitively say it would be beneficial, but we can definitely consider it a possibility.

How many UGL users are using vials for 14 days or longer?

Again, as I said, it's good to bring this information up...but your credibility is hurt if you leave out information in an attempt to prove what you want the data to say.

 

[bjjgear]

Guys are just desperate to feel like generic and pharma are the same. They aren't. Just accept it and enjoy the benefits of Chinese GH if you can't afford pharma, you'll be fine.

 

[Ghoul]

Guys are just desperate to feel like generic and pharma are the same. They aren't. Just accept it and enjoy the benefits of Chinese GH if you can't afford pharma, you'll be fine.

I don't want to feel like it, I want the differences described. We're not talking about magic here, something beyond explanation.

Especially since the only measure between UGL and Pharma being leaned on are purity and dimer tests from a couple of labs, that show no difference, which isn't likely to be the case.

Funny how dimer became a focus, an essential measurement of quality for UGL consumers, but other factors that can be easily checked didn't.

Like, what's the PH of the reconstituted product? That's simple to check and if it's way off the range pharma uses, should be corrected in the UGL product.

 

[bjjgear]

I don't want to feel like it, I want the differences described. We're not talking about magic here, something beyond explanation.

Especially since the only measure between UGL and Pharma being leaned on are purity and dimer tests from a couple of labs, that show no difference, which isn't likely to be the case.

Funny how dimer became a focus, an essential measurement of quality for UGL consumers, but other factors that can be easily checked didn't.

Like, what's the PH of the reconstituted product? That's simple to check and if it's way off the range pharma uses, should be corrected in the UGL product.

Totally agree. Tracy claims to manufacture his own; I'd be interested to see if they are capable of engineering that change (and you'd think someone capable of synthesizing GH to begin with would have had the research background necessary to copy best practices from pharma).