what's your gh dosaging?

[songsofpyramids]

FWIW 2.5mg Tirz offers greater glycemic control, better insulin sensitivity, with fewer sides(likely none), than Sema .25mg.

I was thinking of starting with sema so I can still have tirz in the arsenal for health later in life. I suspect your theory on the diminishing returns with glp1 drugs from hoping on and off them is correct and that eventually the data will show you right. At the very least the study showing those who used liraglutide (I think that was it) showed far less impact with modern glp1 you found was compelling stuff in my eyes. I’m wary of tapping all those receptors for vanity/a cut when they could improve my health down the road if needed. It’s actually been my biggest mental roadblock to starting honestly. I do see these drugs as fairly miraculous, and Alzheimer’s and autoimmune disorders run in my family, so I don’t want to waste my shot with them if the returns are much less over something childish like getting cut af. Was actually going to ask you about this after more research lol. Have any thoughts?

Also curious what your opinions are on using glp1 for autoimmune conditions? It seems like the most miraculous part of all of this in my eyes. The reduction in brain inflammation for Alzheimer’s patients is wild stuff.

I’m not really interested in the weight loss aspect honestly. These other impacts of the drug are what catch my eyes. I’m debating trying to get my mother on them to protect from brain inflammation and general health.

 

[ineffectual]

FWIW 2.5mg Tirz offers greater glycemic control, better insulin sensitivity, with fewer sides(likely none), than Sema .25mg.

It also has less appetite suppression at that dose, which may be desirable if you're not looking for weight loss.

On the other hand, you cannot beat bang for the buck with Sema.

The Current prices on 20mg kits of Sema.... I have plenty on hand but wow.

 

[Bigbicep]

1.6iu let’s goooooo ahahahah yep that’s my daily dose

 

[181]

2iu when I wake up, 2iu when I go to bed. subQ. It has worked well for 15 years at keeping me lean. There may be a better way but that's what's worked for me.

 

[MA11]

Was doing 100mg glutathione am, 2iu post workout, 3iu before bed on workout days, and all 5iu hgh at bed on off days. Next run I’ll be sprinkling .25mg sema on it for blood sugar protection and to see what all the fuss with glp1 is about.

I hope you'll let us know how it goes. I am very interested.
Will this be a cut, maintenance or bulk?

 

[songsofpyramids]

I hope you'll let us know how it goes. I am very interested.
Will this be a cut, maintenance or bulk?

I was thinking the slightest of cuts. 200-400 calories under maintenance. More of a “recomp” but honestly that doesn’t feel right either. Just wanna tighten up a bit.

I will absolutely report back. I’m very curious about the anti inflammatory and mental benefits from low dose glp1 and want to see how well it keeps my a1c steady on one of god’s greatest gifts, recombinant human growth hormone.

1.6iu let’s goooooo ahahahah yep that’s my daily dose

If it works it works man. The impacts of the drug vary so greatly from person to person that I don’t think anyone can tell you the perfect protocol for it but you. Some people respond so strong it’s wild. Saw a dude on another forum pushing 500 igf1 on 1.5iu am and 1.5iu pm where it would take me over 5iu to get there.

What benefits do you see at that dose if you don’t mind me asking?

It has worked well for 15 years

Long time hauler here! Any words of wisdom from your decade and a half on the hgh train?

 

[Grey Spartan]

I was taking 2.4iu but my IGF-1 went down 7 points?! I do have high IGF-1 naturally so I just bumped it up to 3.6 to see what happens.

 

[songsofpyramids]

I do have high IGF-1 naturally

Pump it up bro! I got a buddy who took 3.2iu to get past baseline.

 

[Ateam2023]

I was thinking the slightest of cuts. 200-400 calories under maintenance. More of a “recomp” but honestly that doesn’t feel right either. Just wanna tighten up a bit.

I will absolutely report back. I’m very curious about the anti inflammatory and mental benefits from low dose glp1 and want to see how well it keeps my a1c steady on one of god’s greatest gifts, recombinant human growth hormone.



If it works it works man. The impacts of the drug vary so greatly from person to person that I don’t think anyone can tell you the perfect protocol for it but you. Some people respond so strong it’s wild. Saw a dude on another forum pushing 500 igf1 on 1.5iu am and 1.5iu pm where it would take me over 5iu to get there.

What benefits do you see at that dose if you don’t mind me asking?



Long time hauler here! Any words of wisdom from your decade and a half on the hgh train?

what is your current A1 c, and your fbg, rhr? I know you been on a run with hgh for awhile now , im just curious,

 

[songsofpyramids]

what is your current A1 c, and your fbg, rhr? I know you been on a run with hgh for awhile now , im just curious,

I been off for a little less than 3 months to give the hpa axis a little break. Not sure what my a1c is till next week but my fbg never went over 95 first thing in the am and only when bad about eating after my night injection. It returned to my normal low 80s in the am really quick. I was meticulous with my carbs last round and am hoping glp1 will let me be a little more lenient with carb timing. Rhr went from consistent 74 on hgh to high 50s low 60s after 2-3 weeks. HRV went from 45-55 on hgh to 90s in a month.

 

[Ateam2023]

I been off for a little less than 3 months to give the hpa axis a little break. Not sure what my a1c is till next week but my fbg never went over 95 first thing in the am and only when bad about eating after my night injection. It returned to my normal low 80s in the am really quick. I was meticulous with my carbs last round and am hoping glp1 will let me be a little more lenient with carb timing. Rhr went from consistent 74 on hgh to high 50s low 60s after 2-3 weeks. HRV went from 45-55 on hgh to 90s in a month.

what did you notice when you came off hgh as far as energy/recovery anything else noticeable?

 

[songsofpyramids]

what did you notice when you came off hgh as far as energy/recovery anything else noticeable?

Within 2 weeks of stopping the constant pump was gone and I felt like I looked deflated unless I had just been lifting. By week 3 the super human post workout recovery feel was gone and I felt like I needed to be must more conscientious about rest days and stretching/yoga way more. The general feeling of wellbeing was gone pretty quick and I felt slight rebound on depression and anxiety issues from ptsd, but that resolved very quickly in around a week. I only really noticed the energy hit when doing long hikes or extra long lifting sessions towards the end of them. Nothing drastic. However, I will say, I seriously fucking miss it and much prefer how I feel with consistently high gh serum and igf1. Not like addicted need it kinda feel, but just knowing I felt better on it in my day to day.

 

[malfeasance]

HRV went from 45-55 on hgh to 90s in a month.

What does this part mean?

HRV - Heart Rate Variability? That can't be right. I cannot figure out what you mean.

 

[malfeasance]

Within 2 weeks of stopping the constant pump was gone and I felt like I looked deflated unless I had just been lifting. By week 3 the super human post workout recovery feel was gone and I felt like I needed to be must more conscientious about rest days and stretching/yoga way more. The general feeling of wellbeing was gone pretty quick and I felt slight rebound on depression and anxiety issues from ptsd, but that resolved very quickly in around a week. I only really noticed the energy hit when doing long hikes or extra long lifting sessions towards the end of them. Nothing drastic. However, I will say, I seriously fucking miss it and much prefer how I feel with consistently high gh serum and igf1. Not like addicted need it kinda feel, but just knowing I felt better on it in my day to day.

What was your reason for coming off?

I ask only because of all the posts that claim they will run hgh for life.

EDIT: I think you meant HPS axis?

 

[Ghoul]

I been off for a little less than 3 months to give the hpa axis a little break. Not sure what my a1c is till next week but my fbg never went over 95 first thing in the am and only when bad about eating after my night injection. It returned to my normal low 80s in the am really quick. I was meticulous with my carbs last round and am hoping glp1 will let me be a little more lenient with carb timing. Rhr went from consistent 74 on hgh to high 50s low 60s after 2-3 weeks. HRV went from 45-55 on hgh to 90s in a month.

You answered what I was going to ask about, ie, GLP use,

GLP reduces HRV (not normally a good thing, but apparently without negative consequences although it's suggested patients with heart failure be monitored a bit more closely). This effect comes from the same mechanism that causes increased (or decreased) heart rate in some GLP user.s, specifically, the way GLP interacts with the vagus nerve.

 

[malfeasance]

GLP reduces HRV

So this is heart rate variability, the number of milliseconds between heart beats?

 

[bigMoJo]

So this is heart rate variability, the number of milliseconds between heart beats?

I had to look it up too... found the same... milliseconds between beats. Ideally, need an ekg for that, right? Would you trust a smart watch..? My RHR jumps when I fart.

 

[Ghoul]

So this is heart rate variability, the number of milliseconds between heart beats?

That's accurate, but what it's really a measure of is how much "range" your heart has to adapt to different workloads. A well trained athlete typically has a very high HRV, while a very low HRV is an indicator of impending cardiac catastrophe.

 

[songsofpyramids]

Would you trust a smart watch..?

I honestly don’t trust the smart watch, but I think it gives you a baseline from which to see if things are changing. It’s tracked over time so I always assumed the watch just couldn’t handle the quick change from hormones altering it and getting the data to make sense for it.

specifically, the way GLP interacts with the vagus nerve.

My understanding is also that they exert similar impact on the vagus nerve. At first I found that hrv change alarming, but I think bounces back so quickly after dropping the drug that I gotta awesome it’s just part of its mechanism of action.

 

[FuriousGrill]

That's accurate, but what it's really a measure of is how much "range" your heart has to adapt to different workloads. A well trained athlete typically has a very high HRV, while a very low HRV is an indicator of impending cardiac catastrophe.

The way I understand HRV is that the number it self doesn't matter as much (there are healthy athletes with low HRVs and unhealthy people with high HRVs). Rather, it's the trend upward/downward that we should focus on; if your baseline is 30 and it's going up that's a good sign, but a baseline of 30 isn't necessarily indicative of a problem.