Where can I get some insight on chemistry and production of this compound?

[audiognostic]

Hello.

Thanks for your help guys. I hope I am posting in the right place for this or that someone may have some insight to at least guide me to the right place.

I am interested in experimenting with a compound that was designed to directly raise SHBG levels. It was originally produced to take extreme doses for chemical castration and at those levels it was discontinued due to increases in blood clots, therefore the chemical no longer being available anywhere.

Here is the info:
View media item 1682
apparently it is a special type of SERM and diphenyl benzamide and has a similar structure to stilbestrol derivatives like diethylstilbestrol and triphenylethylene derivatives like chlorotrianisene, this is according to wikipedia

is there any likelyhood of synthezising this compound on a small scale, or modifying a similar available compound to create it for experimentation in a home laboratory? and if so how could i go about doing it? is anyone aware of any other resource group or forum which could help me with this? are there any labs or resources which will synthesize a compound for you for $$$?

please fill me in if you guys can with any guidance.

this is highly appreciated.
Thank you

 

[master.on]

Hello.

Thanks for your help guys. I hope I am posting in the right place for this or that someone may have some insight to at least guide me to the right place.

I am interested in experimenting with a compound that was designed to directly raise SHBG levels. It was originally produced to take extreme doses for chemical castration and at those levels it was discontinued due to increases in blood clots, therefore the chemical no longer being available anywhere.

Here is the info:
View media item 1682
apparently it is a special type of SERM and diphenyl benzamide and has a similar structure to stilbestrol derivatives like diethylstilbestrol and triphenylethylene derivatives like chlorotrianisene, this is according to wikipedia

is there any likelyhood of synthezising this compound on a small scale, or modifying a similar available compound to create it for experimentation in a home laboratory? and if so how could i go about doing it? is anyone aware of any other resource group or forum which could help me with this? are there any labs or resources which will synthesize a compound for you for $$$?

please fill me in if you guys can with any guidance.

this is highly appreciated.
Thank you

For small scale research
it would be cheaper (and certainly simpler) to purchase the pre-made chemical or have it made to order by people who have synthesized it before.

GTX-758 is not in stock, but is available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
GTX-758 | Capesaris | CAS#938067-78-8 | estrogen receptor agonist | MedKoo Biosciences


Price: Get quote
We match the lowest price on market.
CAS:938067-78-8|GTX-758|MuseChem


Just curious on why do you want this chemical?

 

[audiognostic]

Thank you for your reply

I am interested in it for personal experimentation to elevate SHBG levels

I saw the ordering website, however these chemical order websites are often about giving you raw pure material at lab grade and can cost up to a thousand dollars or more per gram, certainly not an effective price when attempting to use it for experimenting with raising SHBG levels

Maybe I am way out of my grade here, I am not sure what it takes to synthesize a generic-pharma quality drug, i guess if it didnt take some multi tens of thousands of dollars lab and if it was plausible to make oneself i would be open to doing so, or seeing if there is any other resource which is able to create lab chemicals like this at a reasonable price

I know its a SERM and similar to other compounds out there so if it was possible just to modify an existing compound this may be much easier than making it from scratch

 

[master.on]

Thank you for your reply

I am interested in it for personal experimentation to elevate SHBG levels

I saw the ordering website, however these chemical order websites are often about giving you raw pure material at lab grade and can cost up to a thousand dollars or more per gram, certainly not an effective price when attempting to use it for experimenting with raising SHBG levels

Maybe I am way out of my grade here, I am not sure what it takes to synthesize a generic-pharma quality drug, i guess if it didnt take some multi tens of thousands of dollars lab and if it was plausible to make oneself i would be open to doing so, or seeing if there is any other resource which is able to create lab chemicals like this at a reasonable price

I know its a SERM and similar to other compounds out there so if it was possible just to modify an existing compound this may be much easier than making it from scratch

Do you want to self-castrate yourself?

Description: GTX-758, also known as Capesaris, is a n orally available, nonsteroidal selective estrogen receptor (ER) alpha agonist with potential antineoplastic activity. Upon administration of GTx-758, this agent suppresses the secretion of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the pituitary gland through feedback inhibition. In males, the inhibition of LH secretion prevents the synthesis of androgens, including testosterone, by the testes. This may result in suppressed total serum testosterone to the levels observed in castration. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
GTX-758 | Capesaris | CAS#938067-78-8 | estrogen receptor agonist | MedKoo Biosciences

 

[audiognostic]

Im already on trt so that does not matter.

There is a small percentage of people with low shbg for whom trt has very underwhelming results i am one of those.. It is a terrible condition i would pay anything to raise my shbg

 

[master.on]

What symptoms did you have?

Some simple treatment suggestions:
http://www.peaktestosterone.com/Low_SHBG.aspx (Low SHBG)

You'll need comprehensive bloodwork

Here is a list of some of the factors that decrease SHBG (8) (9) (10):
Hypothyroidism
Obesity
Androgens (i.e. testosterone)
Insulin
Cortisol
Progestins
The Facts About Sex Hormone Binding Globulin and Thyroid Binding Globulin

Im already on trt so that does not matter.

There is a small percentage of people with low shbg for whom trt has very underwhelming results i am one of those.. It is a terrible condition i would pay anything to raise my shbg

 

[audiognostic]

Yes thank you I'm already working through other things right now and nothing seems to be helping.
I posted this in The Homebrew section because I wanted to see if anybody is familiar with chemistry I am particularly interested in this compound