Bob1990
New Member
I’ll share my bloodwork next week.
I’ve been on rosuva for 1.5 month now.
My lipids were horrible.
Will see what happens
I’ve been on rosuva for 1.5 month now.
My lipids were horrible.
Will see what happens
MESO-Rx
Anabolic Steroids
Who here is on a statin?
- Thread starter Juicedhead
- Start date
RockyP
Member
Rosuva is satisfactory. Side effect profile isn’t as good as pita but it’s not terrible. It will have robust effect at 5-10 mg
It's not just making bad HDL but one of the terminal metabolites from niacin is known to be inflammatory on its own, so it's a double whammy.
A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk - PubMed
Despite intensive preventive cardiovascular disease (CVD) efforts, substantial residual CVD risk remains even for individuals receiving all guideline-recommended interventions. Niacin is an essential micronutrient fortified in food staples, but its role in CVD is not well understood. In this...
pubmed.ncbi.nlm.nih.gov
thegreatestalltime
New Member
For one they are tough on your liver and two certain statins will freely attack your muscle as readily as they will your liver.
No magic pills in this world, everything has its cost.
Ghoul
Member
Show the forum some respect by complying with the rules and writing a new user intro.
Saying "there's no such thing as magic pills" and "everything has a cost" is just spouting some platitudes to back up whatever position you've decided you want to take.
Basing your worldview on pithy sayings doesn't make much sense.
As we understand more and more how and why things work, we are able to make better and better drugs. There are quite a few drugs that have effectively no unwanted side effects when taken at therapeutic doses.
Ghoul
Member
You’re treating a minority risk like a majority outcome.
The old ‘no benefit without cost’ worldview is philosophy, not pharmacology. We measure outcomes, not moral balance.
nullandvoid
Member
Finally got back complete results, with Lp(a) finishing them out. Quite a few other results not pertinent to this thread like DHEA, Vitamin D, Prolactin, B12 etc.. all came back good. Which is remarkable in the case of DHEA because I had been chronically low for years. Can't build mass for shit, but I can stop the hell out of those plaques from forming. True genetic potential.
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Bob1990
New Member
Little update:
My entire bloodwork attached (all I could find)
I tried to find as much from the past I've had and knocked up all in spreadsheet.
I've had a cholesterol problem since I was a kid.
Few years ago diagnosed with hypercholesterolemia..
My lipids are shite because for few years I was on statins they were giving me were causing my muscles tearing apart literally pain af.
Specially with my low Test levels it wasn't helpful for year because 12 years ago I just stopped roids and never came off of it properly no PCT or anything..
In 2022 they sticked me on Atorvastatin 80mg I was knackered after that.
I stopped taking it and then they lovered it to 40mg and included Ezitimibe 10mg.
I kept Ezitimibe and only started Atorvastatin which ended up the same..Agony.
Now I am on Rosuva 5mg only and I am taking Red yeast rice supplements too.. LDL is going down but HDL is going with it too..
I don't feel as much bad now maybe because I've started my TRT 2 months ago now..(doing TRT myself because NHS not keen on starting it and actually I feel better I do it myself)
I do fish oil and CoQ10 supplements too
I wish somehow I could protect my HDL..
I asked for Pitavastatin but apparently NHS is not allowed Pita in UK..
Also need to keep an eye on my Triglicerides
My entire bloodwork attached (all I could find)
I tried to find as much from the past I've had and knocked up all in spreadsheet.
I've had a cholesterol problem since I was a kid.
Few years ago diagnosed with hypercholesterolemia..
My lipids are shite because for few years I was on statins they were giving me were causing my muscles tearing apart literally pain af.
Specially with my low Test levels it wasn't helpful for year because 12 years ago I just stopped roids and never came off of it properly no PCT or anything..
In 2022 they sticked me on Atorvastatin 80mg I was knackered after that.
I stopped taking it and then they lovered it to 40mg and included Ezitimibe 10mg.
I kept Ezitimibe and only started Atorvastatin which ended up the same..Agony.
Now I am on Rosuva 5mg only and I am taking Red yeast rice supplements too.. LDL is going down but HDL is going with it too..
I don't feel as much bad now maybe because I've started my TRT 2 months ago now..(doing TRT myself because NHS not keen on starting it and actually I feel better I do it myself)
I do fish oil and CoQ10 supplements too
I wish somehow I could protect my HDL..
I asked for Pitavastatin but apparently NHS is not allowed Pita in UK..
Also need to keep an eye on my Triglicerides
It looks like RYR in the UK is allowed to contain monacolin k, so this makes more sense than people using it in the US where it is illegal for it to contain it, but monacolin k is chemically identical to lovastatin, the first generation statin that is basically never prescribed anymore because it has one of the worst efficacy to side effect profiles of any statin.
If other statins have given you problems I would be surprised if lovastatin was better - for most people it's among the worst, and you're also effectively doubling up on statin usage.
If other statins have given you problems I would be surprised if lovastatin was better - for most people it's among the worst, and you're also effectively doubling up on statin usage.
Some red yeast rice supplements also could have citrinin in them, which is a toxin that can harm the kidneys. As you point out, since the active ingredient in RYR is a statin, it doesn't make sense to combine it with a statin anyway.
If you aren't tolerating the statins well, maybe consider an alternative to statin such as bempedoic acid.
Decided to come off rosuvastatin today. I was only taking 5mg but something has completely fucked my joints over the last few years. That dry stiff feeling perfectly fits statin side effects. I never used to have joint issues before. I'm keeping repatha and ezetimibe though. I hope it's not too late
Not only that but apparently statins also lower mtor and protein synthesis. In other words statins can potentially fuck you out of your hard earned gains.
Not only that but apparently statins also lower mtor and protein synthesis. In other words statins can potentially fuck you out of your hard earned gains.
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Ghoul
Member
In HIV patients (a group significantly at risk for muscle loss), pitavastatin showed no muscle or strength loss vs. placebo. If you're worried about this, pitavastatin does not enter muscle tissue at a high rate, especially compared to other lyphophilic statins due to some aspects of it's chemistry.
pmc.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
Even "worse" statins don't seem to cause an issue, though, such as atorvastatin
I can't find a study explicitly looking at people on a hypertrophy program and see any direct comparisons but I think we can extrapolate a good bit from these.
No Evidence of Pitavastatin Effect on Muscle Area or Density among People with HIV - PMC
Skeletal muscle area (MA) and muscle density (MD) are key determinants of physical function and typically decline with increasing age. Statins have well-known musculoskeletal effects but whether statins impact MA or MD is not well established, ...
pmc.ncbi.nlm.nih.gov
Pitavastatin Is Well-Tolerated With no Detrimental Effects on Physical Function - PubMed
We observed minimal declines in physical function over 5 years of follow-up among middle-aged PWH, with no differences among PWH randomized to pitavastatin compared to placebo. This finding, combined with low prevalence of myalgias, supports the long-term safety of statin therapy on physical...
pubmed.ncbi.nlm.nih.gov
Even "worse" statins don't seem to cause an issue, though, such as atorvastatin
I can't find a study explicitly looking at people on a hypertrophy program and see any direct comparisons but I think we can extrapolate a good bit from these.
Ghoul
Member
In HIV patients (a group significantly at risk for muscle loss), pitavastatin showed no muscle or strength loss vs. placebo. If you're worried about this, pitavastatin does not enter muscle tissue at a high rate, especially compared to other lyphophilic statins due to some aspects of it's chemistry.
No Evidence of Pitavastatin Effect on Muscle Area or Density among People with HIV - PMC
Skeletal muscle area (MA) and muscle density (MD) are key determinants of physical function and typically decline with increasing age. Statins have well-known musculoskeletal effects but whether statins impact MA or MD is not well established, ...Pitavastatin Is Well-Tolerated With no Detrimental Effects on Physical Function - PubMed
We observed minimal declines in physical function over 5 years of follow-up among middle-aged PWH, with no differences among PWH randomized to pitavastatin compared to placebo. This finding, combined with low prevalence of myalgias, supports the long-term safety of statin therapy on physical...
Even "worse" statins don't seem to cause an issue, though, such as atorvastatin
I can't find a study explicitly looking at people on a hypertrophy program and see any direct comparisons but I think we can extrapolate a good bit from these.
One thing I’ve been remiss about is mentioning the value of CoQ10, esp if concerned about statin muscle issues.
Statins reduce circulating CoQ10 by around 20%. 10-20% of adults have low Coq10 to begin with, so this drop can push them over the edge into low coq10 symptoms (fatigue, muscle soreness, slow recovery).
It seems a lot of people take a Coq10 supplement anyway, but I’m going to try mention it more frequently.
I wasn’t having any issues, but subjectively I’m less tired post workout after starting coq10 (ubiquinol, the bio active type, slightly more expensive, because the more common ubiquinone requires conversion which is impaired in some).
