I've never used it simply because of all I've read...I'm a Clen guy, but the shakes are murder lately....
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MESO-Rx
Anabolic Steroids
Who thinks DNP is simply too dangerous?
- Thread starter bigrobbie
- Start date
ripped_rude
New Member
ignorant people taking DP is too dangerous IMO. it's a very effective fat burner, but then again so is Clen/T3 solid diet
I do not have the full-text.
Grundlingh J, Dargan PI, El-Zanfaly M, Wood DM. 2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death. J Med Toxicol. 2,4-Dinitrophenol (DNP): A Weight Loss Agent with ... [J Med Toxicol. 2011] - PubMed result
2,4-Dinitrophenol (DNP) is reported to cause rapid loss of weight, but unfortunately is associated with an unacceptably high rate of significant adverse effects. DNP is sold mostly over the internet under a number of different names as a weight loss/slimming aid. It causes uncoupling of oxidative phosphorylation; the classic symptom complex associated with toxicity of phenol-based products such as DNP is a combination of hyperthermia, tachycardia, diaphoresis and tachypnoea, eventually leading to death. Fatalities related to exposure to DNP have been reported since the turn of the twentieth century. To date, there have been 62 published deaths in the medical literature attributed to DNP. In this review, we will describe the pattern and pathophysiology of DNP toxicity and summarise the previous fatalities associated with exposure to DNP.
Grundlingh J, Dargan PI, El-Zanfaly M, Wood DM. 2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death. J Med Toxicol. 2,4-Dinitrophenol (DNP): A Weight Loss Agent with ... [J Med Toxicol. 2011] - PubMed result
2,4-Dinitrophenol (DNP) is reported to cause rapid loss of weight, but unfortunately is associated with an unacceptably high rate of significant adverse effects. DNP is sold mostly over the internet under a number of different names as a weight loss/slimming aid. It causes uncoupling of oxidative phosphorylation; the classic symptom complex associated with toxicity of phenol-based products such as DNP is a combination of hyperthermia, tachycardia, diaphoresis and tachypnoea, eventually leading to death. Fatalities related to exposure to DNP have been reported since the turn of the twentieth century. To date, there have been 62 published deaths in the medical literature attributed to DNP. In this review, we will describe the pattern and pathophysiology of DNP toxicity and summarise the previous fatalities associated with exposure to DNP.
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Clinical Features of DNP Toxicity
Routes of Exposure
The oral route is currently the most common route of therapeutic and suicidal exposure.
Dermal exposure can cause yellow staining and may have mild corrosive effects on the skin. Absorption through the skin may lead to systemic effects similar to those seen following ingestion of DNP, although only mild symptoms are usually experienced. Exposure to the eyes may cause yellow discoloration of the sclera with conjunctival injection and irritation.
Dermal exposure is the most common route of unintentional exposure. DNP is used in the chemical industry in wood preservatives, herbicides and dyes and may leak onto industrial sites through landfill and storage tanks. Accidental spills during manufacture and transport are possible and exposure is usually through exposure to the water or dirt that it has leaked on. Although there have been no reports of this occurring, there have been two fatalities related to individuals recycling nylon bags that had previously contained DNP.
Inhalational exposure can happen by breathing contaminated air at DNP-containing waste sites or from incineration fumes. Inhalation of DNP fumes may lead to significant systemic effects, similar to those seen with ingestion.
Organ Systems Affected by Therapeutic Use
There is a small margin between the beneficial effects and the toxic effects of DNP. The most common side effect reported with the therapeutic use of DNP is a rash. This rash can be maculo-papular, urticarial, angiooedematous or a severe exfoliative dermatitis. There is often accompanying pruritis and subsequent desquamation. Prolonged peripheral neuritis has been reported, often affecting the hands and feet and associated with skin changes. A common complaint is that of yellow discoloration of the skin, sclera and urine. This same yellow discoloration is often seen at autopsy and has been confused with jaundice due to reports of liver damage.
T wave and ST segment abnormalities have been noted and some of the earlier autopsied case reports recorded heart muscle damage. Gastroenteritis and anorexia have been reported in high doses. Acute kidney injury, as evidenced by acute tubular necrosis, has been found at autopsy and also reported in two other cases. Confusion, agitation, convulsion and coma are the most common neurological effects reported. Agranulocytosis and neutropaenia have been associated with the therapeutic use of DNP. Cataracts can develop quickly after the use of DNP, usually leading to a permanent decrease in vision to light–dark perception in days to months. Permanent deafness has been reported at doses considered to be therapeutic.
Intentional Overdose
The average time to presentation in the reported cases of acute or suicidal overdose is 7–8 h and the average time of death is 14 h. The onset of symptoms was reported as early as 3 h and 30 min after the overdose.
The usual complaint of the patient is that of profuse sweating. The initial fever is not associated with a change in heart rate or blood pressure, but tachycardia, tachypnoea, shock, confusion, convulsions, cardiovascular collapse and pulseless electrical activity are the eventual consequence of the fatal, deliberate overdose, regardless of treatment.
However, there has been at least one case of survival following deliberate overdose in an 18-year-old female who developed typical features of DNP toxicity [tachycardia of 144 beats per minute, tachypnoea of 38–40 breaths per minute and hyperthermia of 39.7°C (103.4°F)]. She was managed conservatively with intravenous fluids and ice packs to maintain her temperature below 38.3° C (101°F) and was discharged less than 48 h following admission to hospital with no adverse effects at the time of discharge. Ingestion of DNP was confirmed by analysis of gastric lavage contents.
Routes of Exposure
The oral route is currently the most common route of therapeutic and suicidal exposure.
Dermal exposure can cause yellow staining and may have mild corrosive effects on the skin. Absorption through the skin may lead to systemic effects similar to those seen following ingestion of DNP, although only mild symptoms are usually experienced. Exposure to the eyes may cause yellow discoloration of the sclera with conjunctival injection and irritation.
Dermal exposure is the most common route of unintentional exposure. DNP is used in the chemical industry in wood preservatives, herbicides and dyes and may leak onto industrial sites through landfill and storage tanks. Accidental spills during manufacture and transport are possible and exposure is usually through exposure to the water or dirt that it has leaked on. Although there have been no reports of this occurring, there have been two fatalities related to individuals recycling nylon bags that had previously contained DNP.
Inhalational exposure can happen by breathing contaminated air at DNP-containing waste sites or from incineration fumes. Inhalation of DNP fumes may lead to significant systemic effects, similar to those seen with ingestion.
Organ Systems Affected by Therapeutic Use
There is a small margin between the beneficial effects and the toxic effects of DNP. The most common side effect reported with the therapeutic use of DNP is a rash. This rash can be maculo-papular, urticarial, angiooedematous or a severe exfoliative dermatitis. There is often accompanying pruritis and subsequent desquamation. Prolonged peripheral neuritis has been reported, often affecting the hands and feet and associated with skin changes. A common complaint is that of yellow discoloration of the skin, sclera and urine. This same yellow discoloration is often seen at autopsy and has been confused with jaundice due to reports of liver damage.
T wave and ST segment abnormalities have been noted and some of the earlier autopsied case reports recorded heart muscle damage. Gastroenteritis and anorexia have been reported in high doses. Acute kidney injury, as evidenced by acute tubular necrosis, has been found at autopsy and also reported in two other cases. Confusion, agitation, convulsion and coma are the most common neurological effects reported. Agranulocytosis and neutropaenia have been associated with the therapeutic use of DNP. Cataracts can develop quickly after the use of DNP, usually leading to a permanent decrease in vision to light–dark perception in days to months. Permanent deafness has been reported at doses considered to be therapeutic.
Intentional Overdose
The average time to presentation in the reported cases of acute or suicidal overdose is 7–8 h and the average time of death is 14 h. The onset of symptoms was reported as early as 3 h and 30 min after the overdose.
The usual complaint of the patient is that of profuse sweating. The initial fever is not associated with a change in heart rate or blood pressure, but tachycardia, tachypnoea, shock, confusion, convulsions, cardiovascular collapse and pulseless electrical activity are the eventual consequence of the fatal, deliberate overdose, regardless of treatment.
However, there has been at least one case of survival following deliberate overdose in an 18-year-old female who developed typical features of DNP toxicity [tachycardia of 144 beats per minute, tachypnoea of 38–40 breaths per minute and hyperthermia of 39.7°C (103.4°F)]. She was managed conservatively with intravenous fluids and ice packs to maintain her temperature below 38.3° C (101°F) and was discharged less than 48 h following admission to hospital with no adverse effects at the time of discharge. Ingestion of DNP was confirmed by analysis of gastric lavage contents.
Ignitionnet
New Member
No thank you.
I am conservative, I stop at Testosterone and Primobolan for AAS, and nowhere near megadoses for either, I'll happily use ECA and Clenbuterol but I'll draw the line at this stuff. The risk:reward ratio is, for me, far too tilted towards risk from my point of view. Far rather take somewhat longer over weight loss and play it safe than rush and run the risks of the side effects this stuff has.
ECA stack has, according to recent research, been proven as pretty safe, Clenbuterol taken in a reasonable dose is pretty safe, DNP, the research is equivocal to say the least.
I am conservative, I stop at Testosterone and Primobolan for AAS, and nowhere near megadoses for either, I'll happily use ECA and Clenbuterol but I'll draw the line at this stuff. The risk:reward ratio is, for me, far too tilted towards risk from my point of view. Far rather take somewhat longer over weight loss and play it safe than rush and run the risks of the side effects this stuff has.
ECA stack has, according to recent research, been proven as pretty safe, Clenbuterol taken in a reasonable dose is pretty safe, DNP, the research is equivocal to say the least.
ericraven2003
New Member
Used it a half a dozen times with no issue. With this said I only do low dose 200mg a day. It really helped when I lost 46lbs. I also, eat extremely clean while on it an continue to exercise normally. At low dose you shouldn't have problems.
FYI. I cant do ECA or clen. Both give me heart palapations.
FYI. I cant do ECA or clen. Both give me heart palapations.
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whitegato777
New Member
Ive taken up to 900mgs with no serious side effects. Im on 600mgs now and I can bearly keep my temps above 98
University student, 18, known to his friends as Mr Muscles dies 'after taking fat-burning pills'
Sarmad Alladin, 18, taken to hospital hours after praising tablets
University for the Creative Arts tells students: 'Stop using them'
Pills contain the drug DNP, which has been linked to several deaths
Student Sarmad Alladin, 18, known as Mr Muscles dies 'after taking DNP fat-burning pills' | Mail Online
Sarmad Alladin, 18, taken to hospital hours after praising tablets
University for the Creative Arts tells students: 'Stop using them'
Pills contain the drug DNP, which has been linked to several deaths
Student Sarmad Alladin, 18, known as Mr Muscles dies 'after taking DNP fat-burning pills' | Mail Online
Jimmyinkedup
New Member
As I see it this is the biggest problem with DNP. After reading a fairly recent thread and some information and education provided by Dr Jim I did some looking into DNP and the above was one of the conclusions I came too.
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What I don't understand is why do people need a drug to get something accomplished. People are lazy and look for the easy way whatever the cost associated with it. Just go on a damn diet and do some cardio. Quit shoving shit down your pie hole and discipline yourself.
mands
mands
Excellent posts DOC, now will those interested in using this junk finally heed the evidence!
I've been personally involved in the deaths of two patients whom used DNP, one is a published case report which aided the removal (I hope) of this toxin from the market!
Jim
I've been personally involved in the deaths of two patients whom used DNP, one is a published case report which aided the removal (I hope) of this toxin from the market!
Jim
self induced poisoning to lose bodyfat, retarded!!! DNP is for lazy fucks who cant diet hard enough, there are plenty of ways to get to singe digit bodyfat without poisoning yourself, stuff is garbage IMO
Pericles
New Member
Damn, I wish I would have read this BEFORE the ice cream I just ate
I have never taken DNP, so certainly my opinion only means so much. However, I think tren is just as good as burning fat, and a hell of a lot more effective as a strength/muscle builder.
If you don't want sides, sub Mast for tren. A good test/mast or tren/var cycle leans me out really well. It also allows me to bust my ass as hard as I can in the gym for an hour, 4 days a week followed up (on 3 of the 4 weight days) w/ some Yoga and brutal cardio working the bags. I do regular cardio 3 other days. The gear makes it possible to train this hard every day. Off gear I cut the bag work to one-2 days a week, and do another few things to increase recovery (like take a day off when I need it).
To be honest, I did not need to really diet that hard, just clean things up. I could eat late at night, and when I woke up to be leaner and more muscular, especially if doing tren.
Since, based upon what I have read, tren sides are no worse than dnp, why not use the compound that is just as good at burning fat, yet waaaaay better at building muscle and strength?
beezil
New Member
Damn, I wish I would have read this BEFORE the ice cream I just ate
I have never taken DNP, so certainly my opinion only means so much. However, I think tren is just as good as burning fat, and a hell of a lot more effective as a strength/muscle builder.
If you don't want sides, sub Mast for tren. A good test/mast or tren/var cycle leans me out really well. It also allows me to bust my ass as hard as I can in the gym for an hour, 4 days a week followed up (on 3 of the 4 weight days) w/ some Yoga and brutal cardio working the bags. I do regular cardio 3 other days. The gear makes it possible to train this hard every day. Off gear I cut the bag work to one-2 days a week, and do another few things to increase recovery (like take a day off when I need it).
To be honest, I did not need to really diet that hard, just clean things up. I could eat late at night, and when I woke up to be leaner and more muscular, especially if doing tren.
Since, based upon what I have read, tren sides are no worse than dnp, why not use the compound that is just as good at burning fat, yet waaaaay better at building muscle and strength?
Tren is not even close to use as an analogy to DNP. Tren is much more pleasant.
Malik Agar
New Member
Unfortunately, judging by my browsing of different fitness forums, I think it's getting more popular than ever. And mainly from younger, inexperienced types.
Jimmyinkedup
New Member
Very true and sadly i see the same thing with slin at certain boards as well.
ChaseQ
New Member
DNP is a hell of a ride! But oh shit it works!
I did as much research and reading I could do before making a decision to try it.
1. Know the pros and cons
2. Find a reputable source
3. Dont be an idiot
4. watch the fat melt off you...while you feel like hell
Dr Jim, Ive read of deaths due to DNP and they have always been traced back to mega doses. (The ones Ive read about.) Over 600 people die each year to aspirin overdose. This is not an endorsement just my 2cc's.
DNP is a tool in the box. Is it cheating...well fuck we are on a steroid forum, so I guess its a subjective opinion on what is cheating and whats not.
For the record, nothing has caused the dramatic results that simply a monster, dialed diet and training correctly has produced.
I did as much research and reading I could do before making a decision to try it.
1. Know the pros and cons
2. Find a reputable source
3. Dont be an idiot
4. watch the fat melt off you...while you feel like hell
Dr Jim, Ive read of deaths due to DNP and they have always been traced back to mega doses. (The ones Ive read about.) Over 600 people die each year to aspirin overdose. This is not an endorsement just my 2cc's.
DNP is a tool in the box. Is it cheating...well fuck we are on a steroid forum, so I guess its a subjective opinion on what is cheating and whats not.
For the record, nothing has caused the dramatic results that simply a monster, dialed diet and training correctly has produced.
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