JPMOTM
New Member
Gonna have to agree to disagree on this one. But a lot of the confusion is around what are people referring to when they say microdosing. Most people are talking about having the same drug exposure over the week, just dosed more frequently. I.e 1mg EOD rather than 3.5mg per week. People are not talking about doing 0.5mg per week rather than 5mg per week.
But even so, regardless of that, the goal is to reach a steady state concentration which takes about 5 halflives of the drug. You will acheive a steady state dose regardless of the dosing frequency. The idea you need the big peaks only really makes sense in fat and insulin resistant individuals who have downregulated or internalised receptors. Healthy individuals and bodybuilders (dont feel like i can put us quite in the same camp!) wont have this issue. And even if you do need a that higher cmax to trigger a response. You can just take a larger dose more frequently to hit that cmax anyway. Theres no serum concentration thats acheivable in a weekly dose, that isnt acheivable in a more frequent dosing protocol.
Another problem is pharma mounjaro and ozempic have additional compounds added to their formulations to increase the stability of the drug and extend its active life. It is very unlikely that chinese generic GLPs have these same compounds. So the pharmacokinetics are likely a bit different, and the active / half life is likely a bit shorter for the generics. So a more frequent dosing protocol might actually be needed.
So IMO, fat people with diabetes using pharma GLPs, dose once a week. Bodybuilders and healthy individuals using generics. Dose more frequently than once per week. But IT ALL WORKS. Im not arguing against weekly dosing. Im arguing that frequent dosing (what people are referring to when they say microdosing) works.
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