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YK-11, the SARM Exception?
Ever wondered if YK-11 is really a SARM or something else entirely? Get the lowdown on how SARMs compars to Anavar in muscle-building potential, safety concerns, dosing, and why it demands serious caution despite its promise.
This article dives deep into YK-11’s unique steroidal structure, its dual action as an androgen receptor activator and myostatin inhibitor, and why it stands apart from conventional SARMs like LGD-4033 and MK-773.
Author
Cormac Mannion (Type-IIx)
Date
Wednesday, December 17 2025
Type-IIx’s Gear, Growth, and Gains Newsletter is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.
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Table of Contents
Key Takeaways
• YK-11 works through both androgen receptor activation and myostatin inhibition, unlike traditional SARMs that rely solely on selective receptor binding
• The compound’s 3-keto-4-ene steroidal core (like testosterone’s) fundamentally differs from non-steroidal SARMs like LGD-4033
• The research reveals YK-11 as a hybrid compound that blurs the lines between SARMs, myostatin inhibitors, and anabolic-androgenic steroids, offering exceptional muscle-building potential while demanding heightened caution due to its unknown safety profile and regulatory uncertainties.
• In human clinical trials, Anavar blows the SARMs away in terms of efficacy and tolerability. It’s the natural choice unless legal risks or pinning scare yah! It’s an appropriate drug for women, but so is Anavar!
YK-11 is interesting. It’s not your typical SARM. In fact, we might fairly ask: is it even one?
While classified alongside Ligandrol (LGD-4033) and Ostarine (MK-2866), YK-11 deserves a second look – maybe not for people who’ve already or are otherwise willing to use real gear. But certainly for women, those for whom legal risks are greater like those in police work whose concerns are that the “slippery slope” from TRT+ might lead them afoul of the law by eventually deciding to use illegal drugs. And even for many young men, too – who aren’t willing to pin, don’t want to risk significant hepatotoxicity (liver stress), and who (rightly) care about their fertility. Since while not true that SARMs are totally nonsuppressive… it is true that they are only very mildly risky for fertility, and generally only minimally (albeit certainly) suppress LH, sometimes without affecting FSH significantly – and so therefore – spermatogenesis.
So, this begs the question: how do SARMs stack up against a real anabolic-androgenic steroid (AAS) like Anavar?
Well, let’s talk about that! I’ll wrap up this article with a comparison between clinical trial results from the selective androgen receptor modulator (SARM), MK-0773 (MK 773) versus oxandrolone (Anavar).
While I am confident that you’ll agree that YK-11 is the most interesting in the class; it’s also the least researched, with no human trials.
→ CLICK HERE TO READ THE FULL ARTICLE ←
Ever wondered if YK-11 is really a SARM or something else entirely? Get the lowdown on how SARMs compars to Anavar in muscle-building potential, safety concerns, dosing, and why it demands serious caution despite its promise.
This article dives deep into YK-11’s unique steroidal structure, its dual action as an androgen receptor activator and myostatin inhibitor, and why it stands apart from conventional SARMs like LGD-4033 and MK-773.
Author
Cormac Mannion (Type-IIx)
Date
Wednesday, December 17 2025
Type-IIx’s Gear, Growth, and Gains Newsletter is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.
Share
Table of Contents
- YK-11 the SARM Exception?
- YK-11: The Steroidal Outlier in the SARM World
- Author
- Date
- Table of Contents
- Key Takeaways
- YK-11, The SARM Exception
- YK-11’s Molecular Structure and Chemical Classification
- Myostatin Inhibition Through Follistatin Upregulation
- Comparative Analysis: YK-11 versus Conventional Selective Androgen Receptor Modulators
- Structural and Mechanistic Comparison with LGD-4033 and MK-773
- Clinical Research Findings: Efficacy and Safety Profile
- SARMs vs. ANAVAR: The Results Are In, and It’s Not Really Close
- Summary
- About the Author
- Sign Up for Type-IIx’s Newsletter
- References
- YK-11’s Molecular Structure and Chemical Classification
Key Takeaways
• YK-11 works through both androgen receptor activation and myostatin inhibition, unlike traditional SARMs that rely solely on selective receptor binding
• The compound’s 3-keto-4-ene steroidal core (like testosterone’s) fundamentally differs from non-steroidal SARMs like LGD-4033
• The research reveals YK-11 as a hybrid compound that blurs the lines between SARMs, myostatin inhibitors, and anabolic-androgenic steroids, offering exceptional muscle-building potential while demanding heightened caution due to its unknown safety profile and regulatory uncertainties.
• In human clinical trials, Anavar blows the SARMs away in terms of efficacy and tolerability. It’s the natural choice unless legal risks or pinning scare yah! It’s an appropriate drug for women, but so is Anavar!
YK-11 is interesting. It’s not your typical SARM. In fact, we might fairly ask: is it even one?
While classified alongside Ligandrol (LGD-4033) and Ostarine (MK-2866), YK-11 deserves a second look – maybe not for people who’ve already or are otherwise willing to use real gear. But certainly for women, those for whom legal risks are greater like those in police work whose concerns are that the “slippery slope” from TRT+ might lead them afoul of the law by eventually deciding to use illegal drugs. And even for many young men, too – who aren’t willing to pin, don’t want to risk significant hepatotoxicity (liver stress), and who (rightly) care about their fertility. Since while not true that SARMs are totally nonsuppressive… it is true that they are only very mildly risky for fertility, and generally only minimally (albeit certainly) suppress LH, sometimes without affecting FSH significantly – and so therefore – spermatogenesis.
So, this begs the question: how do SARMs stack up against a real anabolic-androgenic steroid (AAS) like Anavar?
Well, let’s talk about that! I’ll wrap up this article with a comparison between clinical trial results from the selective androgen receptor modulator (SARM), MK-0773 (MK 773) versus oxandrolone (Anavar).
While I am confident that you’ll agree that YK-11 is the most interesting in the class; it’s also the least researched, with no human trials.
→ CLICK HERE TO READ THE FULL ARTICLE ←
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