Effect of telmisartan on the regression of left ventricular hypertrophy in essential hypertension

[TRT@40]

Came across this article while looking for ways to control high bloop pressure. For long time users of AAS telmisartan seems useful! what you folks think about this? Anyone used it and seen any improvements with respect to the subject?

Abstract
INTRODUCTION:
An increase in the Left Ventricular Mass as a result of muscle hypertrophy, has emerged as a powerful pressure independent risk factor for the cardiovascular mortality and morbidity. It is associated with a risk of death that is 3 times greater than the risk which is associated with hypertension alone. For the development of Left Ventricular Hypertrophy (LVH), in addition to a chronic increase in the pressure and/or volume overload, an elevation in the plasma ACE activity, plasma aldosterone levels, and the angiotensin-II concentrations play a major role .In this study, the effect of Telmisartan, a selective angiotension-II receptor blocker, was compared with that of Atenolol, a selective β1adrenergic receptor blocker, on the regression of LVH in the patients of essential hypertension.

MATERIAL AND METHOD:
Essential hypertensive patients with LVH were selected for this study, as per the inclusion and exclusion criteria. This study was carried out on two groups of hypertensive patients with LVH: Group-1: The patients who were taking telmisartan 80 mg OD. Group-2: The patients who were taking atenolol 50 mg OD. The blood pressure was measured and echocardiography was done in both the groups, prior to the treatment and 6 months after the treatment in the Department of Cardiology, MKCG Medical College Hospital, Brahmapur, India. The data were analysed by using the Student's 't' test.

RESULTS:
In the cases of Left Ventricular Mass Index (LVMI), which is a better indicator of LVH, in the Atenolol group, the mean value changed from 143.93 ± 2.44 gm/m(2) to 130.16 ± 2.88 gm/m(2) (t=5.83,p<0.01versus baseline).In the Telmisartan group, the mean value changed from 184.67 ± 7.14 gm/m(2) to 133.41± 4.24 gm/m(2) (t=12.12, p<0.001versus baseline). On comparing Telmisartan with Atenolol, Telmisartan was found to produce a greater (27.49%) reduction than Atenolol (9.68%). In the Telmisartan group, 13 patients out of 26 patients achieved a target value of LVMI that was <134 gm/m(2) in males and <110 gm/m(2) in females (50%). In the Atenolol group, only 9 patients out of 22patients achieved a target value (40.90%).

CONCLUSION:
Thus, Telmisartan a selective AT1antagonist, possesses pharmacological effects beyond a blood pressure reduction in which the blockade of the AT1receptor may lead to attenuation of the growth promoting action of Ang II. From this study, it is clear that Telmisartan is superior to Atenolol in achieving a regression of LVH, which is a better indicator of the cardiovascular morbidity and mortality.

 

[TRT]

So...one is better then the other is what I got out of that.

 

[TRT@40]

So...one is better then the other is what I got out of that.

Prior to coming across this article, I was worried about left ventricular hypertrophy, amongst other issues, from years of AAS use that I have planned to put my heart and body thorough. I was little excited to learn there is something I can do to lesson the damage. So, I share this with the community as there might be others who are not aware of this. Or I am the only one without such knowledge?!

 

[AnTabolic73]

Prior to coming across this article, I was worried about left ventricular hypertrophy, amongst other issues, from years of AAS use that I have planned to put my heart and body thorough. I was little excited to learn there is something I can do to lesson the damage. So, I share this with the community as there might be others who are not aware of this. Or I am the only one without such knowledge?!

Bill Roberts wrote the profile for meso. It is intriguing.

https://thinksteroids.com/steroid-profiles/telmisartan/

 

[TRT]

Bill Roberts wrote the profile for meso. It is intriguing.

https://thinksteroids.com/steroid-profiles/telmisartan/

Good read. I live it when people post this shit.

 

[bonacris]

It can also increase nsulin sensitivity in nondiabetics and decrease visceral fat. On my phone sitting On the toilet in work but a quick Google search will bring up studies

 

[Mem1guy]

If your using androgens, there is one supplement that should be in your arsenal-Arjuna.

It has so many benefits when it comes to cardiovascular health. Human studies have shown the positive effects on cardiac function including improved left ventricular function, improved diastolic function, mitral regurgitation(hearts mitral valve doesn't close tightly and allows blood to flow backwards to the heart) and a decrease in cardiac mass.

Suggested dose - 500mg 3x daily of Arjuna aqueous extract.

 

[TRT@40]

If your using androgens, there is one supplement that should be in your arsenal-Arjuna.

It has so many benefits when it comes to cardiovascular health. Human studies have shown the positive effects on cardiac function including improved left ventricular function, improved diastolic function, mitral regurgitation(hearts mitral valve doesn't close tightly and allows blood to flow backwards to the heart) and a decrease in cardiac mass.

Suggested dose - 500mg 3x daily of Arjuna aqueous extract.

Thanks for sharing the benefits of Arjuna.
I normally add a spoon of Ashwaganda in my protein shake. Now, Arjuna will be another addition to 2 protein shakes I take with frozen fruit and yogurt.

 

[HIGHRISK]

Good read.
@Dr JIM any insight on this?

 

[weighted chinup]

Bumping for exposure.

All blood pressures medications as far as I know (beta blockers, ace inhibitors, ARB's) will make an impact in reducing LVH, this study indicated that ARB's were more effective than other blood pressure medications, if this is replicated and consistent then that is pretty significant for our purposes.

I've talked to a lot of pharmacists about these medications and my understanding as I was advised is that the indication for classification of bp med is just based on what you tolerate best or not; it's not a matter of one being stronger than another class of drug; beta blockers are just as good as ace inhibitors which are just as good as arb's and vice versa for most purposes, but if someone has issues with one (cough on ace inhibitors for instance) another class might be indicated.

But depending on how significant that reduction in LVH is, this can easily be the most favorable one for AAS users. At a certain point I don't think increasing dosage will help with certain medications; some ace inhibitors come in certain strengths / dosage but they cap them out pretty early; beyond that they combine multiple types of bp meds from what I've seen in extreme cases of high bp (old timers).

The benefits for telmisartan seem to be more suited for the "self medicate" crowd due to it's safety profile. Then of course there are the possible performance benefits and life extension benefits (insulin sensitivity).

If you are currently px'd a bp medication and ask your doctor about telmisartan they will more than likely write you a px for it so you can try an ARB instead of your ACE inhibitor or beta blocker, you can mention interest in its effects on reducing LVH as a primary point of interest. They might not have a lot of first hand experience with it though, relatively speaking it's a newer drug.

Disclosure: I don't take or have never taken bp meds of any kind, this is just an area of extreme interest for me (cardiovascular health and minimizing mortality with AAS use). That's all.

 

[Dr JIM]

Bumping for exposure.

All blood pressures medications as far as I know (beta blockers, ace inhibitors, ARB's) will make an impact in reducing LVH, this study indicated that ARB's were more effective than other blood pressure medications, if this is replicated and consistent then that is pretty significant for our purposes.

I've talked to a lot of pharmacists about these medications and my understanding as I was advised is that the indication for classification of bp med is just based on what you tolerate best or not; it's not a matter of one being stronger than another class of drug; beta blockers are just as good as ace inhibitors which are just as good as arb's and vice versa for most purposes, but if someone has issues with one (cough on ace inhibitors for instance) another class might be indicated.

But depending on how significant that reduction in LVH is, this can easily be the most favorable one for AAS users. At a certain point I don't think increasing dosage will help with certain medications; some ace inhibitors come in certain strengths / dosage but they cap them out pretty early; beyond that they combine multiple types of bp meds from what I've seen in extreme cases of high bp (old timers).

The benefits for telmisartan seem to be more suited for the "self medicate" crowd due to it's safety profile. Then of course there are the possible performance benefits and life extension benefits (insulin sensitivity).

If you are currently px'd a bp medication and ask your doctor about telmisartan they will more than likely write you a px for it so you can try an ARB instead of your ACE inhibitor or beta blocker, you can mention interest in its effects on reducing LVH as a primary point of interest. They might not have a lot of first hand experience with it though, relatively speaking it's a newer drug.

Disclosure: I don't take or have never taken bp meds of any kind, this is just an area of extreme interest for me (cardiovascular health and minimizing mortality with AAS use). That's all.

Telmisartan (Corgard) was one of the first class of ARBS to enter the US market.

Several others ARBS are now avaliable

The AHA lists ARBs as first line therapy for HTN w or wo LVH.