Grey Spartan
Member
OK, thanks. Looks like I will be ordering from PCT for the first time.
MESO-Rx
Anabolic Steroids
Aromasin vs arimidex
- Thread starter ThE SiCkNeSs
- Start date
Ghoul
Member
Highly recommend Xtane. One of the more
expensive things at PCT, but it's really been amazing for me. Reversed my minor gyno, no sensitive nipples, and "dried out" my emotions.
I'm like that guy on Glengarry Glenross now.
"Your wife left you? I don't care."
"Your kid's got cancer? Talk to a priest."
"I'm here to make money."
I dont think you read the full paper, it clearly shows a reduction in igf1. In this paper there are 2 studies, Study I: dose finding and Study II: PK study .These guys were put in huge doses, 25 and 50mg daily, and saw no impact to IGF.
Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males
Abstract. Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestaneacademic.oup.com
I am glad started out very cautiously though, as only 12.5mg/wk was enough. It takes a long while to recover from too high a dose of this AI.
The PK study give them one dose of 25 mg only and this did not decrease igf1, the study 1 in what they give for 10 days shows a decrease in igf1
Ghoul
Member
It
I'm basing it on their own conclusion, , which I believe indicates the drops were within the margin of error.
After all, if 25mg caused a meaningful drop in IGF, what happened when they gave subjects twice as much, 50mg.......?
I'm basing it on their own conclusion, , which I believe indicates the drops were within the margin of error.
After all, if 25mg caused a meaningful drop in IGF, what happened when they gave subjects twice as much, 50mg.......?
bigpoppachump2
Member
Aromasin all day every day over Adex. I had nothing but problems with Alex and stubbornly kept taking it abuse of the ease of use. But it’s also very easy to crash your estrogen which leads to major issues
I prefer aromasin when cruising but on cruise doses of test (220mg/Wk) aromasin for me is stronger than Adex. 25mg 2x a week put my e2 at 15 where 1mg Adex 2x a week puts me at 35.
However on blast doses of test Asin loses it's potency and I need to use Adex to control my e2. I'm sure it's highly individual. I tend to aromatize a lot even though I'm lean and when using mast I aromatize like crazy, assuming it's from crushed shbg
However on blast doses of test Asin loses it's potency and I need to use Adex to control my e2. I'm sure it's highly individual. I tend to aromatize a lot even though I'm lean and when using mast I aromatize like crazy, assuming it's from crushed shbg
BazzBeat
Member
By the way, I noticed this too. If the test is above 250, then aromasin doesn't seem to help.
BazzBeat
Member
What could be the reason?
It's the same. Aromasin makes E not bounce back as it bounces back after Arimidex. At least not so fast.
YatesIsBased
Member
Switching from Adex to first time using Asin.
At 500mg/wk Test C, no AI, my E2 was at 230.
Adding Adex at 2mg/week my E2 dropped to 89
What's a good starting dose of Asin? (25mg/2x/wk with regular injections?)
Having blood work done monthly to dial it in.
BigTomJ
Member
start at 12.5 twice a week, go get bloodwork and go from there.
YatesIsBased
Member
Got it. Start small and work my way up. Better safe than sorry.
Appreciate you.
Ghoul
Member
100% start this low, or lower. Be patient. Aromasin is a great AI, the best IMO, but too many guys ruin it for themselves by inducing a long lasting E2 crash and the trauma makes them stay away forever after that .
Hope that's pharma too, so you don't get a hot dose....
Easy to get from India if it isn't
Xtane is my preferred.
YatesIsBased
Member
It's UGL. (SSA)
Years ago, I crashed my E2 with Adex when I first started TRT and it was not nice. It only lasted a day or so. I would prefer to avoid that long term.
Never ordered pharma. Do you mind sharing a link, or is that faux pas to ask?
Ghoul
Member
It's not a controlled substance and readily available from India pharma, but we're only permitted to discuss sources in the Underground forum, so I'll DM you.
Ghoul
Member
@YatesIsBased
Couple of use tips.
Get a very sharp pill cutter. The cheap type using a razor blade that's at every drug store is fine.
These are tiny and difficult to split evenly, but that's ok, as long as you only split one at a time.
This way, the two halves equal 25mg over the course of a week, even if the halves are uneven. If you split a bunch, you could end up getting 3 small pieces, then 3 large pieces, and end up with wildly swinging doses week to week.
I use 12.5mg/wk, so split into 6.25mg quarters. which end up varying a lot, but as long as I use 4 in a row it's always 25mg over two weeks, and the long lasting nature of this AI makes that fine.
I'm so paranoid about not overdosing on these, I bought a food safe marker and paint the tabs with it just prior to use so they don't get mixed up with other little white tablets accidentally. (my finasteride are also quartered and look almost identical).
All worth it, since I feel great with these vs other AIs.
Couple of use tips.
Get a very sharp pill cutter. The cheap type using a razor blade that's at every drug store is fine.
These are tiny and difficult to split evenly, but that's ok, as long as you only split one at a time.
This way, the two halves equal 25mg over the course of a week, even if the halves are uneven. If you split a bunch, you could end up getting 3 small pieces, then 3 large pieces, and end up with wildly swinging doses week to week.
I use 12.5mg/wk, so split into 6.25mg quarters. which end up varying a lot, but as long as I use 4 in a row it's always 25mg over two weeks, and the long lasting nature of this AI makes that fine.
I'm so paranoid about not overdosing on these, I bought a food safe marker and paint the tabs with it just prior to use so they don't get mixed up with other little white tablets accidentally. (my finasteride are also quartered and look almost identical).
All worth it, since I feel great with these vs other AIs.
lukiss96
Member
From what I hear it's better than asin for that reason. Perhaps you didn't crash but lowered it too much, so it rebounded quick due to shorter action of adex. I prefer adex myself cuz it's easier to administer and adjust. Some say otherwise, but I don't find any sense in their reasoning. Perhaps they just responded well to a drug and that's it.
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Asin to me is best because I take AI just once in a while when I feel and it's confirmed by blood test that I need it.
If you don't take arimidex continuosly you will fight a rebound all the fucking time.
Asin instead I pop one pill and most of the time is fine for a while until they start climbing again and I'll pop another and I keep doing like that if I feel I'm getting E2 sides.
Adex it's not effective for me used this way.
On the other hand if you crash your E2 with Exemestane yeah it will take longer to have your E2 raise back to an healthy level.
If you don't take arimidex continuosly you will fight a rebound all the fucking time.
Asin instead I pop one pill and most of the time is fine for a while until they start climbing again and I'll pop another and I keep doing like that if I feel I'm getting E2 sides.
Adex it's not effective for me used this way.
On the other hand if you crash your E2 with Exemestane yeah it will take longer to have your E2 raise back to an healthy level.
SnowyMiami
Member
Lower your dose ffs
BigTomJ
Member
Im in the "aromasin is easier to dial in" camp because of the following criteria.
1) Aromasin is not as harsh as adex, making dosing adjustments having less of a knee jerk effect.
2) adex's mechanism means you might have to take it more frequently, depending on your individual clearance times to combat rebound from aromatase opened up when the adex is cleared.
if youre someone who doesnt need a lot of AI, it might be hard cutting adex down to a usable dose if you cant get away with once a week.
3) aromasin is more gradual in its effect, mechanistically, so i could see the argument that adex would be easier in some context because its more immediate, but that gradual effect is exactly why i feel like its easier to really nail down your sweet spot with aromasin.
Combine all that with i just feel better with aromasin and my bloodwork looks better, i lean towards aromasin as the AI of choice.
Im not trying to convince you one way or the other, just outlining my personal reasoning.
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