Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[IronJohnDoe]

I would disclose my proof after I go through a verification process with them, I will not be disclosing my identity for obvious reasons and I will keep my methods private.

I would share my findings and my reasons to believe it is or isn't who they say they are and it's up to the community at that point to make their own decision but it maybe helpful to some if not all.

Oddly enough I've had to do things like this in the past. And I planned on doing this anyways to make sure it is who they say they are or received a green light from others in this community.

So when "Tracy" comes back online to start taking filling and shipping orders and enough time hasn't passed I will share that information and my conclusion here if things aren't already back to normal by that point.

I hope that answers your question.

It actually does and thank you for your reply.
I understand not wanting to share your personal info and I hope that this method to know about Tracy will be useful for the community.

 

[Ghoul]

Interesting. When you say .5ml. I’d have to either take a much stronger dose or reconstitute with a lot more bac water which won’t fit in the vials, so will need transferring.

Any reason (except maybe being sensible) for filtering?

What dose are you currently taking? Vials can hold 3ml.

By filtering you're eliminating immune reaction inducing protein aggregates, as well as particulates (glass, stopper rubber, etc) which further increase the immune response.

This vial appears crystal clear to the naked eye:



Immunogenicity causes antibodies to develop against the peptide, clearing it from the body more quickly, reducing its effectiveness. Over the long term, you can develop a long lasting, even permanent reduction in effectiveness.

In essence, protein aggregates turn the peptide into a "vaccine" like form, causing you to develop an immunity to it.

There are rare, much worse consequences, like the potential of developing cross immunity to the natural hormones Tirz is replicating, but the loss of effectiveness is the most likely risk.

Here's a FDA produced chart of GLP drugs tested for their immunogenic reactions. The samples on the left of each chart are pharma. The two on the right are compounders (ie, legal UGL). As you can see, the immune response to the non-pharma GLPs is as much as 2000x stronger.

The chart on the right shows the impact of filtering. In one of the two non-pharma samples, filtering reduced immunogenicity by 80%, which would help preserve its effectiveness.

 

[Wrangel7]

Hello everyone,

I’d like to provide an update. Approximately 70% of our issues have been resolved, but we still have around 30% left to sort out before we can resume Op. The situation has been far more complicated to resolve than anticipated, and it’s taking much longer than expected. Unfortunately, I can’t provide an exact timeline for when we’ll be back, but I can assure you that we will return soon, despite the significant losses, mental stress, and all the dog shit we've been dealing with during this period. Contrary to what some might imagining us sipping piña coladas on Caribbean black titties, this has been an incredibly difficult ordeal. I sincerely hope no one else has to go through what we’ve endured and are still working to resolve.

The AAS and peptides biz is now heavily regulated and highly risky. Despite all the OPSEC we implemented, our operations were impacted during the crackdown, given the scale of our trading company, we ended up in the same range as production factories. At the end of the day, we’re not operating in the shadows, we’re a legally registered company with offices and warehouses.... so not out of the reach.

Once we’re back, we will make things right for every pending order and every reshipment that’s needed. I’ve always been a man/women of my word, and while financial gain hasn’t been my primary motivation, 2024 has turned into a non-profit year due to these events—despite the hard work we’ve put in throughout the year.

For OPSEC reasons, I can't log in except on very few occasional basis, so sorry about that, but I can't answer any comment after my post until we're back.

We're so back!!

 

[JamesNZ]

What dose are you currently taking? Vials can hold 3ml.

By filtering you're eliminating immune reaction inducing protein aggregates, as well as particulates (glass, stopper rubber, etc) which further increase the immune response.

This vial appears crystal clear to the naked eye:

View attachment 316326

Immunogenicity causes antibodies to develop against the peptide, clearing it from the body more quickly, reducing its effectiveness. Over the long term, you can develop a long lasting, even permanent reduction in effectiveness.

In essence, protein aggregates turn the peptide into a "vaccine" like form, causing you to develop an immunity to it.

There are rare, much worse consequences, like the potential of developing cross immunity to the natural hormones Tirz is replicating, but the loss of effectiveness is the most likely risk.

Here's a FDA produced chart of GLP drugs tested for their immunogenic reactions. The samples on the left of each chart are pharma. The two on the right are compounders (ie, legal UGL). As you can see, the immune response to the non-pharma GLPs is as much as 2000x stronger.

The chart on the right shows the impact of filtering. In one of the two non-pharma samples, filtering reduced immunogenicity by 80%, which would help preserve its effectiveness.

View attachment 316324

Bro, do you have any links with all this information you share, together in one place? Or a number of links. I have a mate who has what seems to be an auto immune response after he pins peptides. I'm just wondering it this info could help him.. Sorry for being a pain.

 

[Wrangel7]

Immunogenicity causes antibodies to develop against the peptide, clearing it from the body more quickly, reducing its effectiveness. Over the long term, you can develop a long lasting, even permanent reduction in effectiveness.

Could this be causing desensitisation to rHGH more so than very high injection frequency?

https://academic.oup.com/jcem/article-abstract/87/8/3573/2846550

 

[Ghoul]

Could this be causing desensitisation to rHGH more so than very high injection frequency?

https://academic.oup.com/jcem/article-abstract/87/8/3573/2846550

Yes.

HGH is the only peptide / protein drug routinely monitored for immunogenicity at the clinic level. There's a blood test available for it.

One of the ways it's dealt with is switching brands, to see if antibody levels go down and the HGH starts working again. Since all HGH is somatropin, the only difference between brands are the excipient ingredients in the formulation, which mainly serve to minimize aggregation to prevent immunogenicity.

Here are children who lost response to HGH from immunogenicity and the methods used to try and fix it. "Inhibition" is how much HGH effectiveness was reduced.



Here's a measure of the antibodies produced by different pharma formulations, most of which can be attributed to aggregates.



UGL is certainly worse. No anti-aggregate measures are taken (slightly wrong PH alone can cause aggregation to get 10x worse). No immunogenicity tests are conducted. "I've never noticed immunogenicity". Would you notice a 15-20% drop in effectiveness over a year?

Filtering reduces immunogenicity, ensures sterility, prevents particulates like common glass delamination and stopper rubber from getting into your body and eventually your organs where they accumulate, causing micro embolisms. It's all upside.

 

[annih]

What dose are you currently taking? Vials can hold 3ml.

....

Thanks Ghoul.

I am taking 2.5mg, only a small amount. My wife is taking 5mg. So I'd need to put 5ml of BAC water in for her schedule and 10ml for what I take. I know mine is on the outlier of GLP usage, but for me its enough, but hers is a typical dose.

Really useful regarding filtering. I was filtering other stuff, hadn't (for some reason) occurred to me to do the peptides too!

 

[Ghoul]

Thanks Ghoul.

I am taking 2.5mg, only a small amount. My wife is taking 5mg. So I'd need to put 5ml of BAC water in for her schedule and 10ml for what I take. I know mine is on the outlier of GLP usage, but for me its enough, but hers is a typical dose.

Really useful regarding filtering. I was filtering other stuff, hadn't (for some reason) occurred to me to do the peptides too!

You can't use the same filters as those for oils .

Use .22um PES 13mm filters, without prefilter.

Sterile 0.2 μm PES Syringe Filters

Hydrophilic PES syringe filters with single or double-layer membrane. Pore sizes of 0.2μm. Diameter of 13mm/25mm/33mm with Luer lock. Sterile individually packed.

shop.cobetter.com

Inject filtered peptide into particle free certified vials like Ultra Spec.

Ultra Spec Sterile 5ml (20mm neck) Clear Sealed Glass Vial, Qty 1

5ml clear sealed sterile glass vials (Silver seal, single). Shop at Med Lab SUpply for high quality medical and lab glass!

www.medical-and-lab-supplies.com

 

[annih]

@Ghoul - read my mind, was going to ask what filters you'd recommend. Thank you. Any reason for no pre-filter?

 

[Excel.exe]

@Ghoul - read my mind, was going to ask what filters you'd recommend. Thank you. Any reason for no pre-filter?

same.

 

[Excel.exe]

for anyone else wondering what they should use for oils

PTFE 0.22micron 33mm, 20ml syringes hand, 50ml for caulking gun

 

[Wrangel7]

Yes.

HGH is the only peptide / protein drug routinely monitored for immunogenicity at the clinic level. There's a blood test available for it.

One of the ways it's dealt with is switching brands, to see if antibody levels go down and the HGH starts working again. Since all HGH is somatropin, the only difference between brands are the excipient ingredients in the formulation, which mainly serve to minimize aggregation to prevent immunogenicity.

Here are children who lost response to HGH from immunogenicity and the methods used to try and fix it. "Inhibition" is how much HGH effectiveness was reduced.

View attachment 316328

Here's a measure of the antibodies produced by different pharma formulations, most of which can be attributed to aggregates.

View attachment 316329

UGL is certainly worse. No anti-aggregate measures are taken (slightly wrong PH alone can cause aggregation to get 10x worse). No immunogenicity tests are conducted. "I've never noticed immunogenicity". Would you notice a 15-20% drop in effectiveness over a year?

Filtering reduces immunogenicity, ensures sterility, prevents particulates like common glass delamination and stopper rubber from getting into your body and eventually your organs where they accumulate, causing micro embolisms. It's all upside.

Thank you!

Here are my relatively low IGF-1 levels after using about 90iu/day of QSC HGH.

Somatomedin-C (IGF-1) ↑ 977.5 ng/mL 134.0 - 450.0 Serum

Will taking a break help enough if it's this bad, and how long before I can restart with the most effectiveness returned? I'm assuming this can only be figured out after testing.

I've also reduced my frequency, as indicated by the study I sent, before coming off for a little while.

Would you suggest I do RIA for anti-HGH antibody detection? Is ELISA fine? Functional IGF-1 Response Test? Neutralizing Antibody Test? Or is RIA pretty much the only quality go-to?

How long do anti-HGH antibodies persist? I'm assuming my natural production has probably tanked, too.

Would switching brands from QSC temporarily help, or would it have to be a permanent switch? Would it have to be a switch to a pharma brand, or something like SSA would work? Do we know anything about the differences in excipients and aggregation properties between QSC and SSA rHGH?

What about secretagogues for a while?

Do we know anything about the doses taken in this study? Could you please link the study?

Thanks again, Ghoul; so much value each time interacting with you!

 

[bananafeet]

What do you notice from adding kisspeptin. Been reading up on it seems promising

I think it adds mental drive and more sex drive? I'm just as bad as I was on tren (harassing my wife for sex).

I added it after asking Tracy for something for NAFLD, apparently it has been shown in rats to help with that.

It's hard to know if that's what's doing it or just an increase in general fitness.

I am also on semaglutide 1mg twice per week and I continue to lose weight quite rapidly (from QSC also).

It probably would help to add I am on TRT because I have primary hypogonadism, I never touched exogenous androgens before starting TRT.

 

[zagreus]

You can't use the same filters as those for oils .

Use .22um PES 13mm filters, without prefilter.

Sterile 0.2 μm PES Syringe Filters

Hydrophilic PES syringe filters with single or double-layer membrane. Pore sizes of 0.2μm. Diameter of 13mm/25mm/33mm with Luer lock. Sterile individually packed.

shop.cobetter.com

Inject filtered peptide into particle free certified vials like Ultra Spec.

Ultra Spec Sterile 5ml (20mm neck) Clear Sealed Glass Vial, Qty 1

5ml clear sealed sterile glass vials (Silver seal, single). Shop at Med Lab SUpply for high quality medical and lab glass!

www.medical-and-lab-supplies.com

Thanks for sharing your knowledge.

What is the purpose of filtering into the separate vial, if filtering already occurs at injection time?

 

[Trenbolonetax]

Thank you!

Here are my relatively low IGF-1 levels after using about 90iu/day of QSC HGH.

Somatomedin-C (IGF-1) ↑ 977.5 ng/mL 134.0 - 450.0 Serum

Will taking a break help enough if it's this bad, and how long before I can restart with the most effectiveness returned? I'm assuming this can only be figured out after testing.

I've also reduced my frequency, as indicated by the study I sent, before coming off for a little while.

Would you suggest I do RIA for anti-HGH antibody detection? Is ELISA fine? Functional IGF-1 Response Test? Neutralizing Antibody Test? Or is RIA pretty much the only quality go-to?

How long do anti-HGH antibodies persist? I'm assuming my natural production has probably tanked, too.

Would switching brands from QSC temporarily help, or would it have to be a permanent switch? Would it have to be a switch to a pharma brand, or something like SSA would work? Do we know anything about the differences in excipients and aggregation properties between QSC and SSA rHGH?

What about secretagogues for a while?

Do we know anything about the doses taken in this study? Could you please link the study?

Thanks again, Ghoul; so much value each time interacting with you!

90iu per day? Is this correct?

 

[Trenbolonetax]

I think it adds mental drive and more sex drive? I'm just as bad as I was on tren (harassing my wife for sex).

I added it after asking Tracy for something for NAFLD, apparently it has been shown in rats to help with that.

It's hard to know if that's what's doing it or just an increase in general fitness.

I am also on semaglutide 1mg twice per week and I continue to lose weight quite rapidly (from QSC also).

It probably would help to add I am on TRT because I have primary hypogonadism, I never touched exogenous androgens before starting TRT.

Reta obliterates NAFLD. Check out the trials

 

[Wrangel7]

90iu per day? Is this correct?

Yep. Super desensitised. Over 2 vials of 36 iu a day from QSC.

 

[bananafeet]

Reta obliterates NAFLD. Check out the trials

Yeah mate I've got two kits from Tracy in the fridge. I just want to keep them as a back up option in case massive weight loss doesn't work.

Currently I'm down 26kg (136kg to 110kg). Hoping for another 20 odd kg. If that doesn't kill it off I'll go the reta. I've got another abdomen scan booked in 6 months time. Given it was only a mildly fat infiltrated liver I'm hoping semaglutide induced weightloss will be enough.

But apparently fatty liver can be a very stubborn disease. It's great we now have an option at least that burns fat right at the liver.

 

[DinoBB76]

Yep. Super desensitised. Over 2 vials of 36 iu a day from QSC.

what effects did you have with 90 units? how did you divide them?

it seems that your body cannot recognize the external hormone and I discarded it

 

[SpaceGhost]

It's not just the titties.. Stuff like calling himself a "man/women" and calling it peptide biz.. maybe I'm just too paranoid

Glad it's not just me feeling off about that message. It's like when a show comes back after they had to replace one of the characters with a new actor. Taking a wait and see approach on this one.