MESO-Rx Sponsor Opti USA DOMESTIC - HGH, INJECTABLES, TABLETS, PEPTIDES, & MISC

[throwawaybb21]

Can you offer 1-test-cyp for sale on the website or do we have to email you for that? @Opti

 

[ackmack78]

So many options for hgh, it's hard to know which one to pick.

 

[Delux]

So many options for hgh, it's hard to know which one to pick.

GH degrades once reconstituted, for that reason I would stay away from the gold top 32iu unless you are doing 10+ iu's a day.

 

[Ateam2023]

GH degrades once reconstituted, for that reason I would stay away from the gold top 32iu unless you are doing 10+ iu's a day.

just filter it and your g2g ,, ahahaaaa

 

[Juiced_lizard]

GH degrades once reconstituted, for that reason I would stay away from the gold top 32iu unless you are doing 10+ iu's a day.

What? I use a 40IU vial and do 5IU a day. No problems.

 

[The Answ3r]

GH degrades once reconstituted, for that reason I would stay away from the gold top 32iu unless you are doing 10+ iu's a day.

I’m no GH expert - just recently started using it myself - but from everything I’ve read, GH stays stable for 10-14 days at 2-8°C with bacteriostatic water.

Gold top 32IU vials are fine if you’re running 3+ IU/day - you’ll finish it before any real degradation kicks in. If you’re on lower doses, smaller vials might be the better move unless you enjoy the thrill of wondering whether your GH is still working every morning.

At the end of the day, as long as you store it properly and use it within a reasonable timeframe, there’s nothing to worry about.

 

[Delux]

just filter it and your g2g ,, ahahaaaa

What? I use a 40IU vial and do 5IU a day. No problems.

I’m no GH expert - just recently started using it myself - but from everything I’ve read, GH stays stable for 10-14 days at 2-8°C with bacteriostatic water.

Gold top 32IU vials are fine if you’re running 3+ IU/day - you’ll finish it before any real degradation kicks in. If you’re on lower doses, smaller vials might be the better move unless you enjoy the thrill of wondering whether your GH is still working every morning.

At the end of the day, as long as you store it properly and use it within a reasonable timeframe, there’s nothing to worry about.

This post by @readalot is very insightful into GH stability, your GH is degrading by as much as 80% by day 7 even at cold temperatures.

 

[kaizoku]

This post by @readalot is very insightful into GH stability, your GH is degrading by as much as 80% by day 7 even at cold temperatures.

What post?

 

[The Answ3r]

This post by @readalot is very insightful into GH stability, your GH is degrading by as much as 80% by day 7 even at cold temperatures.

I’m just starting to learn about HGH, so there might be mistakes in my response, and I could be wrong in some areas. That said, here’s my take on it.

I checked out the full study, and while it provides useful data, I don’t think it directly applies to how pharma HGH is stored and used in real life.

From what I gathered, the study tested HGH in basic buffer solutions (Tris and phosphate) without stabilizers and looked at chemical and physical degradation over time.

1. In a phosphate buffer at 5°C, it seemed chemically stable for 4+ days, but ELISA results showed possible aggregation after day 2.
2. In a Tris buffer at 5°C, HGH stayed stable for 4+ days without major degradation.

Why I don’t think this fully applies to pharma HGH:

1. Pharma HGH (Genotropin, Norditropin, Humatrope, etc.) contains stabilizers like m-cresol and glycerin, which help it stay stable much longer.
2. Companies like Pfizer, Novo Nordisk, and Lilly state that HGH remains good for 14–28 days at 2–8°C, and they base this on HPLC testing and real-world bioassays.
3. If HGH really lost 80% potency in 7 days at 2–8°C, pharma companies wouldn’t approve month-long use periods post-reconstitution.
4. Stability studies on actual pharma HGH show minimal degradation over weeks, not days, when stored properly.

How this relates to UGL HGH:

1. UGL HGH doesn’t always have the same stabilizers, so it breaks down faster than pharma versions. From what I’ve seen, most people say it starts losing potency after 10–14 days, which is why many try to use it quickly.
2. The typical UGL HGH formulation (Lobster) includes:
- 5g Mannitol - Helps with lyophilization (freeze-drying) but doesn’t stabilize HGH.
- 16.8 mg Sodium Dihydrogen Phosphate & 51.12 mg Disodium Hydrogen Phosphate – Basic phosphate buffer that helps with pH balance but doesn’t prevent aggregation or extend stability.

Some vendors add glycine before lyophilization, which might help slow degradation, but it’s unclear how much it actually extends shelf life compared to pharma-grade stabilizers like m-cresol.

Unlike pharma HGH, most UGL versions still lack preservatives that significantly extend post-reconstitution stability.

This is why UGL HGH is best used within 10-14 days after mixing, while pharma HGH remains stable for weeks.

Final thoughts

The study looked at HGH in simple buffer solutions, not the kind of formulations used in pharma HGH. Pharma HGH is designed to last weeks, not just days, because of added stabilizers.

For UGL HGH, we now know that some vendors add glycine before lyophilization, which might help with stability, but it’s still not the same as pharma HGH with preservatives like m-cresol. Degradation still happens faster, which is why users report noticeable potency loss after 10-14 days.

If I misunderstood something, I’m open to correction, but based on what I’ve read, the idea that HGH loses 80% in 7 days at 2-8°C doesn’t match real-world data - unless we’re talking about UGL HGH without proper stabilizers, which does degrade faster.

 

[Juiced_lizard]

This post by @readalot is very insightful into GH stability, your GH is degrading by as much as 80% by day 7 even at cold temperatures.

You quoted me with apparently something yet didn’t link anything. What are you trying to show?

 

[readalot]

I’m just starting to learn about HGH, so there might be mistakes in my response, and I could be wrong in some areas. That said, here’s my take on it.

I checked out the full study, and while it provides useful data, I don’t think it directly applies to how pharma HGH is stored and used in real life.

From what I gathered, the study tested HGH in basic buffer solutions (Tris and phosphate) without stabilizers and looked at chemical and physical degradation over time.

1. In a phosphate buffer at 5°C, it seemed chemically stable for 4+ days, but ELISA results showed possible aggregation after day 2.
2. In a Tris buffer at 5°C, HGH stayed stable for 4+ days without major degradation.

Why I don’t think this fully applies to pharma HGH:

1. Pharma HGH (Genotropin, Norditropin, Humatrope, etc.) contains stabilizers like m-cresol and glycerin, which help it stay stable much longer.
2. Companies like Pfizer, Novo Nordisk, and Lilly state that HGH remains good for 14–28 days at 2–8°C, and they base this on HPLC testing and real-world bioassays.
3. If HGH really lost 80% potency in 7 days at 2–8°C, pharma companies wouldn’t approve month-long use periods post-reconstitution.
4. Stability studies on actual pharma HGH show minimal degradation over weeks, not days, when stored properly.

How this relates to UGL HGH:

1. UGL HGH doesn’t always have the same stabilizers, so it breaks down faster than pharma versions. From what I’ve seen, most people say it starts losing potency after 10–14 days, which is why many try to use it quickly.
2. The typical UGL HGH formulation (Lobster) includes:
- 5g Mannitol - Helps with lyophilization (freeze-drying) but doesn’t stabilize HGH.
- 16.8 mg Sodium Dihydrogen Phosphate & 51.12 mg Disodium Hydrogen Phosphate – Basic phosphate buffer that helps with pH balance but doesn’t prevent aggregation or extend stability.

Some vendors add glycine before lyophilization, which might help slow degradation, but it’s unclear how much it actually extends shelf life compared to pharma-grade stabilizers like m-cresol.

Unlike pharma HGH, most UGL versions still lack preservatives that significantly extend post-reconstitution stability.

This is why UGL HGH is best used within 10-14 days after mixing, while pharma HGH remains stable for weeks.

Final thoughts

The study looked at HGH in simple buffer solutions, not the kind of formulations used in pharma HGH. Pharma HGH is designed to last weeks, not just days, because of added stabilizers.

For UGL HGH, we now know that some vendors add glycine before lyophilization, which might help with stability, but it’s still not the same as pharma HGH with preservatives like m-cresol. Degradation still happens faster, which is why users report noticeable potency loss after 10-14 days.

If I misunderstood something, I’m open to correction, but based on what I’ve read, the idea that HGH loses 80% in 7 days at 2-8°C doesn’t match real-world data - unless we’re talking about UGL HGH without proper stabilizers, which does degrade faster.

Very nice summary. I assume you were trying to link this material:

R

Post in thread 'How long does HGH last once mixed at room temp?'

Sep 18, 2024

Ive seen the Janoshik report of GH losing almost 50% potency after being reconstituated and left at room temperature for 6 days, but do you think 12-16 hours @ room temp will have much of a degradation effect? Cant really find any info on how quickly it starts degrading

Fig.1
hGH stability in Tris and phosphate buffers (0.05 M, pH=7.4) analyzed by HPLC and ELISA tests. A. At 5 ± 2℃ and B. At 37 ± 1℃. hGH; Human growth hormone, HPLC; High performance liquid chromatography, and ELISA; Enzyme-linked immunosorbent assay


See the...

• readalot

• 

Absolutely great point on the excipient comments. We know alot from the studies on the effect of excipients on lyophilized GH shelf life and degradation. Less seems to have been published on what happens after reconstitution. The material posted above shows worst case scenario for GH in buffered solutions. Like you said pharma GH labeling allows for 10 to 14 day storage in fridge after reconstitution.

 

[readalot]

The typical UGL HGH formulation (Lobster) includes:
- 5g Mannitol - Helps with lyophilization (freeze-drying) but doesn’t stabilize HGH.
- 16.8 mg Sodium Dihydrogen Phosphate & 51.12 mg Disodium Hydrogen Phosphate – Basic phosphate buffer that helps with pH balance but doesn’t prevent aggregation or extend stability.

Note Lobster has also mentioned glycine but has not disclosed amounts and final pH prior to lyo after multiple asks.

Thanks for all your effort.

 

[readalot]

I'll try to dig a little more. Haven't read this paper yet.

https://academic.oup.com/ajhp/article-abstract/55/14/1508/5157774

Also see here under stability section:

Somatropin, rh-GH

Elsevier’s Monographs offer are a quick and easy way to find evidence-based answers to your clinical questions. Access a concise, easily scannable summary on the drug Somatropin, rh-GH.

elsevier.health

 

[Ateam2023]

This post by @readalot is very insightful into GH stability, your GH is degrading by as much as 80% by day 7 even at cold temperatures.

but who lets there hgh sit for 7 days reconstituted , honestly,,

 

[dick_starbuck]

but who lets there hgh sit for 7 days reconstituted , honestly,,

Yeah... this.

Maybe longevity guys only using 2iu a day?

 

[Juiced_lizard]

but who lets there hgh sit for 7 days reconstituted , honestly,,

I do. 40IU Vial at 5iu a day lasts me 8 days. I’ve never had a problem. Not saying that’s the best way to do it but just what I do.

 

[readalot]

Yeah... this.

Maybe longevity guys only using 2iu a day?

Raise hand....18 IU ÷ 2 IU per day.

 

[Ateam2023]

Raise hand....18 IU ÷ 2 IU per day.

hows that serostim treating you? How many weeks has it been?

 

[readalot]

hows that serostim treating you? How many weeks has it been?

Starting week 4. So far so good. Nothing noticeable.

Week 1: 1.5 IU/d
Week 2: 1.8 IU/d
Week 3: 2 IU/d
Week 4: " "

Will pull IGF-1 soon.

Thanks for asking.

 

[readalot]

This post by @readalot is

And my apology. I could not make out the link you had shared there. Yep, that's the one.