MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
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Whopperflopper
Member
Yes, type 2. No HGH in a while, only on Trt 125 wk. Definitely thinking about it again now.
Not sure if posted already here but recently talked with my doctor regarding a sleep study and we had a nice chat about GLP1's and he told me that he can soon prescribe GLP1's as sleep apnea medication.
Article: FDA Approves First Medication for Obstructive Sleep Apnea
Article: FDA Approves First Medication for Obstructive Sleep Apnea
Hey guys, I'm afraid that tirzepatide is loosing effectivness.
I started 6weeks ago. First week did 2.5mg and felt nothing so next week I went to 5 and it hit hard. I lost about 15lbs in just 3weeks and I felt great, I had no hunger at all and actually had to force myself to eat at times.
I have struggle with binge eating/hyperphagia for many years and I was happy I was finally relieved from it. Tho in the last 2 weeks my appetite has been coming back full force and I've regained about 3-4lbs. Why did this happen? I went from forcong myself to eat to being hungry 24/7 like I was before in like a few days
I started 6weeks ago. First week did 2.5mg and felt nothing so next week I went to 5 and it hit hard. I lost about 15lbs in just 3weeks and I felt great, I had no hunger at all and actually had to force myself to eat at times.
I have struggle with binge eating/hyperphagia for many years and I was happy I was finally relieved from it. Tho in the last 2 weeks my appetite has been coming back full force and I've regained about 3-4lbs. Why did this happen? I went from forcong myself to eat to being hungry 24/7 like I was before in like a few days
Juiced_lizard
Member
Losing 15 lbs is 15 lbs Even if you didn’t “feel” anything. I’m not sure forcing yourself to eat is really the point of it. 3-4 lbs could just be normal fluctuations. High sodium, diet, etc etc. I think people should look at it as a long term thing not short term. You CAN out eat GLP’s.
Lot of men in my opinion don’t “feel” much (or notice) until higher doses. I’d keep going up. All is just my opinion though.
Are you mixing your tirz properly? Taking it once weekly? I noticed micro dosing didn’t work as good as every 7 days personally I tried both just to try both.
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OldGHGuy
Member
I've taken the plunge on GLP-1's (Tirz) for the first time so thought I would report. Mid 50's.
Finished my winter bulk/strength cycle end of January at 285, 21% BF. Ate like an asshole but hit my strength goals and put on a surprising amount of muscle from a fairly mild cycle. Back on TRT/Cruise February 1st. Clean diet all of February and dropped down to 275, much of which was water loss after the cycle.
March 1st started Tirz at 2.5 mg. Dont necessarily care about total bodyweight - I'm most interested in losing half of the 60+ pounds of fat I'm carrying + to see how lean I can get. Chose Tirz due to less appetite suppression (I want to ideally maintain all of my muscle so eating is key)
Amazed at my results the first week: lost almost 6 pounds without changing diet at all as I experienced no noticeable appetite suppression. Slight nausea occasionally after eating.
Will report back ocasionally. Loving it so far.
Finished my winter bulk/strength cycle end of January at 285, 21% BF. Ate like an asshole but hit my strength goals and put on a surprising amount of muscle from a fairly mild cycle. Back on TRT/Cruise February 1st. Clean diet all of February and dropped down to 275, much of which was water loss after the cycle.
March 1st started Tirz at 2.5 mg. Dont necessarily care about total bodyweight - I'm most interested in losing half of the 60+ pounds of fat I'm carrying + to see how lean I can get. Chose Tirz due to less appetite suppression (I want to ideally maintain all of my muscle so eating is key)
Amazed at my results the first week: lost almost 6 pounds without changing diet at all as I experienced no noticeable appetite suppression. Slight nausea occasionally after eating.
Will report back ocasionally. Loving it so far.
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nullandvoid
Member
Since Cardarine has come up, anyone have any experience with GW-0742? Essentially "super cardarine." I bought some a long time ago and never had the balls to try it.
Ghoul
Member
This is how GLPs work.
Once you reach a certain weight at a certain dose, the plateau, appetite suppression and side effects stop. If you regain significant weight, appetite suppression and sides will return until you drop the weight again. A slight variation of a few pounds is normal.
To go lower, you increase the dose. When you plateau, if you want to go lower, you increase the dose.
Once you reach your goal weight, and feel no appetite suppression, you stay at your "maintainance dose" indefinitely from then on.
Studies involving over ten thousand subjects show stable weight at a maintainance dose for at least 4 years.
GLPs are a type of exogenous hormone, that establish your body's "homeostasis weight". The more you add, the lower that "setting" goes.
Think of them like TRT for a hypogonadal man or insulin for a diabetic.
nullandvoid
Member
I'm finally at 15mg of Tirz myself. I haven't had this kind of appetite suppression since the early days of 2.5mg. I did a miserable job of eating chips and salsa last night, and my favorite cheat meal of a massive chicken and chorizo burrito was pathetic.. maybe able to eat 1/3 of it. It's actually too much suppression really, and that was my first 15mg dose having increased from 10mg. I'm about ten pounds out from being around 6%... which is actually quite a bit. Things seem to be getting asymptotic. I will say that since adding T3 after finding my rT3 was high has started to make quite a bit of difference.
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Ghoul
Member
Suppression will lighten up as you lose fat. The metabolic "signal" that tells your body to reduce appetite and impose unpleasant sides to enforce that reduction in energy intake comes from fat, not gross weight.
If you get to goal weight at 15mg, and appetite returns to a comfortable level, that's pretty close to ideal, since the non-weight loss health benefits are more pronounced with higher doses.
The people who reach goal weight and end up with low maintenance doses may be at a disadvantage in that regard.
If it's still too much suppression just fall back to a lower dose, giving it two weeks to see if you've lowered the dose enough.
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nullandvoid
Member
I've got a friend that simply cannot go past 2mg. For him and his sister, both of them are crazy hyper-responders. He has gone days without eating and has had to dial back dosage a few times. I keep trying to hammer into him to make sure he gets enough protein. He's a big guy with a lot of fat, but he's absolutely the mesomorph type. Very muscular/strong. He's lost over 30 pounds so far, but I'm sure with his lack of intake, a non-trivial amount of that has been muscle. We're both using the same source's Tirz (QSC's), though he recently bought a few 30mg kits from Nexaph to future-proof himself a bit due to any potential coming drought.
sorry maybe I worded it poorly. The first week on 2.5mg I felt nothing, second week I went to 5mg and then I started feeling the effects and I lost weight. I mean that for the past 3 weeks it gave me strong appetite suppresion and now all of a sudden it's gone and I'm hungry as usual and have regained some weight
Ghoul
Member
GLP related metabolic disease, like it's becoming increasingly apparent most of obesity is, can be linked to either insufficient GLP production, or a sensitivity/receptor problem.
Sounds like your friend doesn't have an issue with sensitivity, but produces insufficient GLP, so even a tiny amount creates a huge response,
Production or sensitivity problems can actually be detected on a genetic test, predicting strong or weak response to GLPs.
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the issue isn't only that the appetite supression is gone, but I'm also extremely hungry again and I'm regaining weight bit by bit. It's like I lost weight and them completely stopped taking tirz, I'm almost doubting if I got a few bunk vials
Ghoul
Member
Unfortunately with UGL we have added layers of complexity.
A bunk/underdosed batch or even a single vial that's bad among a kit that's otherwise good.
Potentially rapid degradation because of a number of factors that aren't an issue with precision made pharma.
Then there's the possibility of immunogenicity, developing higher levels of antibodies that cause your immune system to remove the drug from your system quickly, reducing its effectiveness,
So you may have involuntarily "come off" or "lowered the effective dose" because of any of these factors.
Was this a batch that had been working? If so, maybe it's a bad vial.
If it's a new batch, maybe it's bunk or underdosed. You can try increasing the dose,
Finally, if it's immunogenicity, you could try filtering with a .22um PES syringe filter. Hopefully, by eliminating the trash from your tirz, this would lower the immune response, antibody levels would drop, and it's effectiveness would be restored.
When the FDA filtered some compounded Tirz, one of the formulations showed an 80% drop in immunogenicity using the standard in vitro test.
(pre and post filtration immune response shown on the chart on the right with the compounded samples, the two on the far right of each chart. The higher of the two compounded GLPs showed an immune response 2000x stronger than the pharma products which are on the left of each chart.).
Finally, try to make sure all doses are at least .5ml in volume. This will also reduce immune response,
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You seem to be the most knowledgeable on this forum but I can't find a recent source and idk if I. Just not searching correctly or what do I thought I would ask you who people are using now that QSC apparently is on hold. I stocked up 12/23 and havent been following forums since then but now that I find myself in need Tracey isn't responding so I came here looking.
Ghoul
Member
I'm not, I just pay close attention and post a lot, lol.
There's no Q replacement and all sources have gotten flakier since they left
Go to the Underground section and look at the top 3-4 threads in the sponsored (top of the forum) and unsponsored sections. Those are the most active. Start at the end of each and read back a few pages. Pick whichever sells what you need and you see reports of successful landings from.
It's only going to get worse for the next few months at least.
Does it seem like it's been harder or easier to locate lots of glp-1s?
I assumed it would be easier now, but that was before the current American administration and the popularity of the glp-1s.
Ghoul
Member
In general peptides are still making it through customs without much of an issue. but if you find a supplier that works for you, I wouldn't let any grass grow under my feet, and make sure I had a healthy "buffer" supply on hand to ride out any problems that may suddenly arise. You don't want an involuntary interruption in treatment.
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