Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[Sampei]

That’s something I’ve always been curious about - why it seems to work that way. In theory, someone should still be able to lose weight on a lower dose if they’re in a proper deficit, doing cardio, and training consistently. So I wonder if the idea of a “plateau” on GLP-1s has more to do with how people approach it.

Maybe it’s less about the drug losing effect and more about the behaviors around it - like relying on the appetite suppression instead of using it as a tool to build better habits. Not judging at all, just genuinely interested in how much of it is physiological vs psychological.

You nailed it. Of course you can still lose weight even at the same dosage, it's just harder. You gotta do it the old way, with pain tears and hunger. I mean it's funny because we all don't even know what's real hunger, we have NO IDEA. it's kind of a shame when we say shit like: I'm hungry all the time. I mean please bitch you have no fucking idea what HUNGER is. I don't. You don't. He doesn't.

 

[Luke391]

That’s something I’ve always been curious about - why it seems to work that way. In theory, someone should still be able to lose weight on a lower dose if they’re in a proper deficit, doing cardio, and training consistently. So I wonder if the idea of a “plateau” on GLP-1s has more to do with how people approach it.

Maybe it’s less about the drug losing effect and more about the behaviors around it - like relying on the appetite suppression instead of using it as a tool to build better habits. Not judging at all, just genuinely interested in how much of it is physiological vs psychological.

I think you just don't understand not everone's body can just be lean and feel fine. when I wasn't on Tirz and would get down to 15% bf I'd be starving all day long every day, even after maintaining 15% bf for months my body never would adjust, just constant hunger for months on end. eventually I was just bound to regain the weight, no matter how good my habits were

 

[Luke391]

The body has an energy homeostasis system. In other words, it wants to be a certain size/level of fat stores.

Below that it induces you to eat via physical and physiological mechanisms. Digestion speeds up. Sense of smell sharpens. Mouth waters. Increasingly invasive thoughts about food.

Above that level, digestion slows, food seems unappetizing, even the thought of "eating one more bite" can induce nausea.

Exogenous GLP hormones simply lower that "setting" your body wants to maintain.

All the "appetite suppression" effects are the same things you'd experience after gorging yourself to excess on a large meal by forcing yourself to eat beyond your appetite.

exactly. when I was lean and not on tirzepatide all I could think about was food and even just bland stuff like lean meat and fruit would make my mouth water, I would be going for walks and walk by all the bakeries just to look at the sweets from outside. being hungry litterally turns you into a fuking weirdo. I also would develop all sorts of strange behaviours and obsessions, like if my mother made my bed I'd feel extremely angry and guilty because I hadn't done it myself in the morning. weird shit like that,

 

[Luke391]

That’s a really clear explanation - thanks for laying it out like that. Makes a lot more sense now why GLP-1s feel the way they do. It’s wild how they mimic the “I’m way too full” state without needing to actually eat that much.

Also makes me wonder - do you think that “set point” is mostly genetic? Like, some people seem stuck at a certain weight no matter how hard they diet, while others stay lean without much effort. I guess GLP-1s help shift that point, but I’m curious how much flexibility we really have long-term.

I belive so. every time I lost weight naturally I'd feel horrible

 

[Sampei]

I think you just don't understand not everone's body can just be lean and feel fine. when I wasn't on Tirz and would get down to 15% bf I'd be starving all day long every day, even after maintaining 15% bf for months my body never would adjust, just constant hunger for months on end. eventually I was just bound to regain the weight, no matter how good my habits were

15% bf is not lean lol

and you were hungry because you were starving yourself to get to 15%.
You probably have no clue on how to manipulate your body and exercise etc.
You should learn on how to fire your metabolism and pack muscle so that to be at 15% you don't even have to make an effort.

You can eat lasagna and pizza and stay at 15%. Sorry but you have no fucking clue of what you are talking about, I read only a bunch of excuses from an individual that hasn't optimized his body in anyway.

 

[Luke391]

15% bf is not lean lol

and you were hungry because you were starving yourself to get to 15%.
You probably have no clue on how to manipulate your body and exercise etc.
You should learn on how to fire your metabolism and pack muscle so that to be at 15% you don't even have to make an effort.

You can eat lasagna and pizza and stay at 15%. Sorry but you have no fucking clue of what you are talking about, I read only a bunch of excuses from an individual that hasn't optimized his body in anyway.

you're the one who has no idea. you're always calling others retards on this forum but your advice on everything is atroicious.

 

[Sampei]

you're the one who has no idea. you're always calling others retards on this forum but your advice on everything is atroicious.

Sure crybaby keep telling yourself that.
Starving being 15% bf what a joke.

Sure you gonna starve, if you wanna be 15% bf while sitting on a couch doing nothing.

 

[Luke391]

15% bf is not lean lol

and you were hungry because you were starving yourself to get to 15%.
You probably have no clue on how to manipulate your body and exercise etc.
You should learn on how to fire your metabolism and pack muscle so that to be at 15% you don't even have to make an effort.

You can eat lasagna and pizza and stay at 15%. Sorry but you have no fucking clue of what you are talking about, I read only a bunch of excuses from an individual that hasn't optimized his body in anyway.

you constantly say idiotic shit on GLPs and AAS, you belive everyone else's experience is the same as yours amd not capable of understanding that not everyone's body reacts the same to different things.

 

[Luke391]

Sure crybaby keep telling yourself that.
Starving being 15% bf what a joke.

Sure you gonna starve, if you wanna be 15% bf while sitting on a couch doing nothing.

you are making shit up to validate your argument. this isn't even about drugs, you are litterally saying that a person you don't know and have never seem has not experienced what say they have experience. litteral children make belive games

 

[Ateam2023]

you constantly say idiotic shit on GLPs and AAS, you belive everyone else's experience is the same as yours amd not capable of understanding that not everyone's body reacts the same to different things.

im pretty sure "EVERYONEs" body responds to some seroius cardio, You can't deny that,, Calorie defecit/cardio, eating right, your gonna reap benefits,

 

[Luke391]

I'd go trough all the bulshit you say and lay it out one by one but you're restricted your profile so

 

[Luke391]

im pretty sure "EVERYONEs" body responds to some seroius cardio, You can't deny that,, Calorie defecit/cardio, eating right, your gonna reap benefits,

hunger is hunger, no matter how much cardio you do

 

[Luke391]

ohh "Food noise" ?

not even food noise, actual hunger. being lean is not normal for everyone. and why the fuck would I want to suffer to be lean, this is not a suffering contest, I want to look good and feel good, all the willpower guys are just trying to fill their egos.
if I can be lean, have some muscle and be healthy with minimal effort thanks to some injections I'd be an idiot not to do it

 

[Sampei]

im pretty sure "EVERYONEs" body responds to some seroius cardio, You can't deny that,, Calorie defecit/cardio, eating right, your gonna reap benefits,

Eating smart, training smart, it's not even about discipline... If one makes his own body work properly it will burn fuel it will allow to eat you more and even slack here and there on the diet and you will still improve your physique, especially when the goal is a normal 15% bf lol

 

[Ateam2023]

not even food noise, actual hunger. being lean is not normal for everyone. and why the fuck would I want to suffer to be lean, this is not a suffering contest, I want to look good and feel good, all the willpower guys are just trying to fill their egos.
if I can be lean, have some muscle and be healthy with minimal effort thanks to some injections I'd be an idiot not to do it

after all it is "What your comfortable with",, i totally understand,, Have a Grateful day ,,

 

[Sampei]

not even food noise, actual hunger. being lean is not normal for everyone. and why the fuck would I want to suffer to be lean, this is not a suffering contest, I want to look good and feel good, all the willpower guys are just trying to fill their egos.
if I can be lean, have some muscle and be healthy with minimal effort thanks to some injections I'd be an idiot not to do it

You will never look good, no matter how much Tirzepatide you inject

I'm not against GLP1 at all, it's just ridiculous when ppl like you make statement like the one you do.

You don't even understand why you are hungry, you just think it's you being unlucky instead of you being unable to train and improve your metabolism properly

 

[Luke391]

You will never look good, no matter how much Tirzepatide you inject

I'm not against GLP1 at all, it's just ridiculous when ppl like you make statement like the one you do.

You don't even understand why you are hungry, you just think it's you being unlucky instead of you being unable to train and improve your metabolism properly

it's not about effort it's about genes.
tall people are respected, short people are ridiculed
good looking people are admired, ugly people are shunned
fit people are praiaed for their "hard work", out of shale people are shamed for their "lack of discipline"
smart people are praised, dumb people are takem advanted of and insulted

it's all just luck. you might have gotten lucky and belive everyone else just doesn't try

 

[Ghoul]

That’s a really clear explanation - thanks for laying it out like that. Makes a lot more sense now why GLP-1s feel the way they do. It’s wild how they mimic the “I’m way too full” state without needing to actually eat that much.

Also makes me wonder - do you think that “set point” is mostly genetic? Like, some people seem stuck at a certain weight no matter how hard they diet, while others stay lean without much effort. I guess GLP-1s help shift that point, but I’m curious how much flexibility we really have long-term.

I heard a researcher lay this out as a theory regarding the spread of obesity from country to country over the last 60 years, despite being rare, even in places with essentially unlimited food before then.

GLP is the primary "satiation" hormone that regulates energy intake.

As humans evolved, fruit was a primary food source. A particular fruit would ripen all at once, and only be around for a short period of time.

Fructose, the form of sugar in fruit, stimulates hunger, glucose does not. The mechanism isn't fully understood.

This may have developed to allow us to overcome normal appetite limitations in order to take advantage of an abundant, but briefly available supply of calories in ripe fruit.

Obesity at high levels seems to correlate with the broad introduction of fructose (via high fructose corn syrup) into the food supply.

This started in the US in the 1970's with bread and baked foods of all types, beverages. cereal, snacks, even processed meat.

As the use of HFCS spread to other countries, 15-20 years later you'd see obesity rates (and diabetes) start to sharply increase.

So the theory goes that with continuous exposure to large amounts of fructose, particularly as children, GLP sensitivity was permanently downregulated and in many people. the system of GLP moderated energy homeostasis "broke", resulting in a dysfunctional appetite continuously demanding calories beyond what's required, with all the intensity of an alcohol or opioid addiction.

 

[Sampei]

it's not about effort it's about genes.
tall people are respected, short people are ridiculed
good looking people are admired, ugly people are shunned
fit people are praiaed for their "hard work", out of shale people are shamed for their "lack of discipline"
smart people are praised, dumb people are takem advanted of and insulted

it's all just luck. you might have gotten lucky and belive everyone else just doesn't try

I was a little fat when young and I was skinny fat later on, I love to eat and I can easily binge eat like a pro. You just like to tell yourself a story that suits your narrative.

I have been there I know what your lazy bum is talking about. When I started going to the gym I had no muscle and the first time I tried to get lean I had to eat 1500kcal and I was hungry all the time.

Easy explanation, if you have no muscle you ain't burning calories so your body needs very little calories to survive and so to get lean you need to starve yourself. If you build muscle and train your body in being a furnace you will find yourself being able to get lean without starving yourself, I'm talking normal level of leanness (not 15% lol what a joke) I'm talking 10/12% year around.

Again to be 15% you can eat whatever you want if you train consistently and are on TRT, ZERO EFFORT.

To be sub 10%? Yeah unless genetically gifted you will feel the hunger.

But that's a world you never even walked on once so it's useless to even talk about it.

You have NO CLUE what real hunger is, I have no clue either.

Being hungry all the time trying to maintain 15% bf it means only one thing: you don't do shit all day long or you a cardio bunny.

Luck? Yeah keep telling yourself that. You really sound like an incel

 

[The Answ3r]

I think you just don't understand not everone's body can just be lean and feel fine. when I wasn't on Tirz and would get down to 15% bf I'd be starving all day long every day, even after maintaining 15% bf for months my body never would adjust, just constant hunger for months on end. eventually I was just bound to regain the weight, no matter how good my habits were

I get what you’re saying, and I don’t want to dismiss your experience - chronic hunger at lower body fat is real for a lot of people. But I’ve got to be honest, I don’t fully agree with the idea that some people “just can’t” stay lean.

Unless there’s a serious medical condition involved, the body can lose fat and maintain a leaner set point. It’s just incredibly difficult, both mentally and physically. In most cases, it’s not that the body won’t adapt - it’s that the process requires a level of precision and consistency most people underestimate: training, diet quality, recovery, stress management, everything.

So for me, it’s less about “can or can’t” and more about how far someone’s willing to go and how smartly they do it. I’m glad GLP-1s are helping you get there - they’re a great tool when used the right way.