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Your numbers aligned closely with the results of a paper I read recently, which is why I suspected you injected IM.

In a study of trained, lean athletes, IM produced GH peaks more than 2.5x higher than SubQ at the same dose. This was with doses similar to PED use, not the low medical GH replacement doses.

Numbers are given as Mean (Minimum / Maximum).

View attachment 334800

Area under the curve (total exposure to GH) IM was from 1.5x to 2x higher than SubQ. From what I understand, this significantly boosts GH's fat loss and cognitive effects.

IGF was roughly the same for IM and SubQ. Area under the curve (total exposure to IGF) was slightly less with IM (~10%), reducing the IGF anabolic effect a little.

View attachment 334801

Overall, it looks like you might get a lot "more" out of a dose using IM administration than SubQ. All the GH receptor benefits (fat burning. cognition) of a dose more than twice as high, while only sacrificing 10% of the IGF (anabolic) benefits.

View attachment 334802


Thanks for sharing that. If you want the full study lmk and I'll DM you a copy. Out of curiosity, any particular reason you started injecting IM?
I always injected gh IM, weird to say maybe but I got used to with my daily Sustanon injections, so I thought I already know how to pin a muscle as I rotate between 12 sites and the gh needles are micro.
Always thought that I felt it more at same dosage than friends doing sub-q but I thought it was placebo, thanks for popping the study, now it make sense.
 
Gimme two weeks.

Vince Mcmahon Wwe GIF
 
Your numbers aligned closely with the results of a paper I read recently, which is why I suspected you injected IM.

In a study of trained, lean athletes, IM produced GH peaks more than 2.5x higher than SubQ at the same dose. This was with doses similar to PED use, not the low medical GH replacement doses.

Numbers are given as Mean (Minimum / Maximum).

View attachment 334800

Area under the curve (total exposure to GH) IM was from 1.5x to 2x higher than SubQ. From what I understand, this significantly boosts GH's fat loss and cognitive effects.

IGF was roughly the same for IM and SubQ. Area under the curve (total exposure to IGF) was slightly less with IM (~10%), reducing the IGF anabolic effect a little.

View attachment 334801

Overall, it looks like you might get a lot "more" out of a dose using IM administration than SubQ. All the GH receptor benefits (fat burning. cognition) of a dose more than twice as high, while only sacrificing 10% of the IGF (anabolic) benefits.

View attachment 334802


Thanks for sharing that. If you want the full study lmk and I'll DM you a copy. Out of curiosity, any particular reason you started injecting IM?
That's very interesting, thank you sharing that. Would love the full study to peruse.

Since some IGF-1 seemingly 'disappears' via the IM route compared to subQ, I wonder if some of it is getting converted to IGF1 - and potentially spliced to MGF - in the in injected muscle? If not the area under the curve should be the essentially same regardless of parental admin route. Higher peak with IM makes sense as absorption rate is generally IV>IM>subQ.

Overall it seems the fat loss and cognitive effects should be maximized with IM admin, while IGF1 hyperplasia/anabolic effects should be maximized with subQ admin. I've been using GH subQ for a few years now, but maybe I will trial my daytime injections IM into lagging body parts (biceps in particular), and my PM injection subQ to see if I get acheve some site enhancement via local IGF1>MGF.

When I graduated from secretagogues to GH, I would get carpal tunnel symptoms > 3 iu/day. I have now titrated up to 7iu/day (1.5iu morning + 1.5iu early evening/preworkout, and 4iu before bed) without any symptoms or water retention. I typically restrict carbs to pre- and post-workout in the pm. I do this to maximize lipolysis and minimize insulin resistance from FFA release; I also use both berberine and dihydroberberine/taxifolin with non-keto meals, and use Reta (4mg/wk taken M/W/F) and low dose empoglaflozin too. I'm probably overdoing it with insulin sensitivity drugs, but I also use rosuvastatin which increases risk of NODM - in process of switching to pitavastatin which does not.

Btw I source GH from Opti USA (40iu gold tops) and SSA (36iu). Both seem excellent. I've been using 3cc of BSW which is probably not enough, but I have been too lazy to dilute in a larger vial. I previously used K4L but had a lot of vials that mixed up cloudy, despite releasing the vacuum and gently dripping water down the sides of the vial. Still seemed to work fine but this has not been an issue with Opti or SSA.

This combo along with a low dose custom HRT protocol (testosterone, trestolone, primobolan, masteron, and trenbolone totallng 250mg/wk minus ester weight) has gotten me to (high) single digit body fat at 6' 200lbs at 57yo.
 
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Your numbers aligned closely with the results of a paper I read recently, which is why I suspected you injected IM.

In a study of trained, lean athletes, IM produced GH peaks more than 2.5x higher than SubQ at the same dose. This was with doses similar to PED use, not the low medical GH replacement doses.

Numbers are given as Mean (Minimum / Maximum).

View attachment 334800

Area under the curve (total exposure to GH) IM was from 1.5x to 2x higher than SubQ. From what I understand, this significantly boosts GH's fat loss and cognitive effects.

IGF was roughly the same for IM and SubQ. Area under the curve (total exposure to IGF) was slightly less with IM (~10%), reducing the IGF anabolic effect a little.

View attachment 334801

Overall, it looks like you might get a lot "more" out of a dose using IM administration than SubQ. All the GH receptor benefits (fat burning. cognition) of a dose more than twice as high, while only sacrificing 10% of the IGF (anabolic) benefits.

View attachment 334802


Thanks for sharing that. If you want the full study lmk and I'll DM you a copy. Out of curiosity, any particular reason you started injecting IM?
I would greatly appreciate a copy of the study, brother. Thanks for sharing this info.
 
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