Low Estradiol? Here's How DHEA Can Fix Your "Crashed" E2

[adrenalytic]

This thread is of great interest to me as I am currently off-test for labs.

Does the E2 remain elevated only as long as the drug is active? DHEA-S appears to have a half life of 7-10 hours. Does the additional E2 drop off at that point, meaning you would have to dose twice daily?

 

[Stealth500]

This thread is of great interest to me as I am currently off-test for labs.

Does the E2 remain elevated only as long as the drug is active? DHEA-S appears to have a half life of 7-10 hours. Does the additional E2 drop off at that point, meaning you would have to dose twice daily?

I read the elimination half life is super short

 

[adrenalytic]

I read the elimination half life is super short

which isn't inherently bad if the 60 mins. for "significant" serum boost is true. I just want to know if twice daily dosing makes the most sense. And then would that mean 50 mg twice a day for a total of 100 mg? Would side effects be more pronounced at that dose?

 

[Stealth500]

which isn't inherently bad if the 60 mins. for "significant" serum boost is true. I just want to know if twice daily dosing makes the most sense. And then would that mean 50 mg twice a day for a total of 100 mg? Would side effects be more pronounced at that dose?

Pretty sure 100mg a day isn't going to be detrimental.. In that study i posted people were also taking 1600mg a day.

I think being a supplement and not FDA approved people play it safe with advice and err on the side of caution with the minimal dose. The harvard website has an article that listed a bunch of potential side effects of misuse.

DHEA supplements: Are they safe? Or effective? - Harvard Health

DHEA is a supplement that some people take to fight the effects of aging. But does it work? And is it safe?...

www.health.harvard.edu

 

[ChemBB]

He asked how quickly it would take effect.

That's fair

Though IMO, pulling a quote about an acute + transient increase and omitting that the persistent change was net-zero isn't the most useful info and can be misleading

It's sort of like saying:

"SuperTestoSupp caused a 2,000% increase of serum testosterone within 15 minutes of ingestion"

While not mentioning that serum T concetrations of SuperTestoSupp users were identical to placebo over a 24-hour window

 

[Stealth500]

That's fair

Though IMO, pulling a quote about an acute + transient increase and omitting that the persistent change was net-zero isn't the most useful info and can be misleading

It's sort of like saying:

"SuperTestoSupp caused a 2,000% increase of serum testosterone within 15 minutes of ingestion"

While not mentioning that serum T concetrations of SuperTestoSupp users were identical to placebo over a 24-hour window

supposedly quoting.

literally copied and pasted..

I don't know what better study could a person could ask for on the topic.

It's a controlled study where men (not menapausal women or rats or whatever else) are taking various amounts of the substance and getting bloodwork done. I posted it to provide some substance for debate as there are no citations in the OP just hyperlinks to paid content.

here's the full paragraph i pulled that from.

"Acute hormone response to DHEA administration. Ingestion of 50 mg of DHEA resulted in increased serum androstenedione concentrations within 30 min (Fig. 2; P � 0.05) that peaked at 150% above baseline by 60 min after ingestion. Serum androstenedione concentrations tended to decline after 60 min but remained significantly elevated for 360 min after ingestion of DHEA (P � 0.05). Ingestion of PL resulted in no change in serum androstenedione concentrations. Serum concentrations of LH and FSH were also not altered during the 360 min after ingestion of DHEA or PL. Ingestion of DHEA or PL did not alter the serum concentrations of
free testosterone or total testosterone. Serum E2 concentrations increased significantly 60 min after ingestion of PL and DHEA (main effect for time, P � 0.05) and were not different between the two groups."