MESO-Rx
Anabolic Steroids
Solid as expected. The only thing I experienced was redness and itching in the spot for 3 days. Tried a few different things and nothing helped. But it did its job and it wasn’t the biggest deal.
Any chance this will be available in the US?
Interesting. Reta no longer has any effect on my appetite no matter the dosage (been up to 20mg). Do you think you would get more appetite suppression if you added a small dose of semaglutide to reta? I don't understand what sema does that reta doesn't (if you take enough of it).
Instead of combining another GLP you can switch over to tirzepatide since it has a stronger appetite supression effect or combine reta wifh cagrilintide
20mg goddamn. How long have you been on reta?? Yes many get better suppression of sema or tirz
I've never heard of anyone taking 20 mg of Reta When you started, did it affect your appetite? If it weren't OPTI, I'd say it was a fake, but that's a no-brainer.
I've been using Reta for 5 weeks at 1 mg per week. My goal was to curb nighttime binge eating, but I'm having a hard time doing that. I chose Reta to get all the metabolic benefits, trying to build lean mass in a caloric surplus without accumulating too much fat and curb nighttime binges. During the day, I don't have much of an appetite and I don't feel any stomach rumbling, but in the evening after training, I eat constantly. I haven't slept well for years. I wake up every hour and start eating. After this, I fall asleep despite using melatonin and magnesium. I thought about increasing the dose to 2 mg, but I doubt it will improve things.Primo: la differenza tra RETA e SEMA non riguarda "quanto ne prendi", ma quali recettori stimoli e come il tuo corpo risponde ad essi
RETA attiva tre recettori: GLP-1, GIP e il recettore del glucagone (GCGR).
Questo crea l'effetto metabolico più forte e la maggiore perdita di peso totale, ma non sempre la più forte soppressione dell'appetito. A dosi più elevate, il sistema si adatta spesso. La stimolazione GIP + GCGR controbilancia parzialmente il segnale di sazietà GLP-1, quindi potresti non avvertire più una significativa riduzione dell'appetito, anche a dosi elevate.
SEMA, invece, è un agonista GLP-1 puro e molto potente con effetti molto più forti su: rallentamento dello svuotamento gastrico, aumento della sazietà indotta dal pasto + soppressione dell'appetito centrale nell'ipotalamo.
Spesso RETA non rallenta lo svuotamento gastrico in modo così aggressivo perché GIP + GCGR modulano tale effetto.
RETA ad alto dosaggio -> minima soppressione dell'appetito
Sema a basso dosaggio ->- massiccia soppressione dell'appetito
Non è una questione di quantità. È una questione di farmacodinamica.
In base alla mia esperienza personale e a quella di oltre 50 clienti con cui ho lavorato negli ultimi anni sulle terapie GLP-1/GIP/GCGR, il modello è molto coerente:
RETAa = ideale per il cambiamento metabolico, la perdita di grasso e la riduzione dell'HbA1c
SEMA = il più forte per la soppressione dell'appetito
Microdosaggio di SEMA in aggiunta a RETA = la soluzione ideale una volta che RETA smette di sopprimere l'appetito
Se qualcuno desidera una guida più approfondita sui protocolli GLP-1/GIP/GCGR, sulle strategie di perdita di grasso, sulle impostazioni di prestazione o sull'interpretazione delle analisi del sangue, non esiti a contattarmi. Lo faccio professionalmente.
Over a year
Yes it worked well and I got the skin sensitivity side effect as well as appetite suppression. After a few weeks both weaned off until I upped the dosage again.
Interesting, I'll give it a try. I don't really need to lose weight and I never really did but these drugs make it easier to stay lean and avoid binging. I never experienced slower gastric emptying with reta.First: the difference between RETA and SEMA isn't about "how much you take" but which receptors you stimulate and how your body responds to them
RETA activates three receptors: GLP-1, GIP and glucagon receptor (GCGR).
This creates the strongest metabolic effect and the largest total weight loss, but not always the strongest appetite suppression. At higher doses, your system often adapts. The GIP + GCGR stimulation partially counterbalances the GLP-1 satiety signal, so you may no longer feel much appetite reduction, even at high doses.
SEMA, meanwhile is a pure, highly potent GLP-1 agonist with much stronger effects on: slowing gastric emptying, increasing meal-induced satiety + central appetite suppression in the hypothalamus.
RETA often does not slow gastric emptying as aggressively because GIP + GCGR modulate that effect.
High dose RETA -> minimal appetite suppression
Low dose Sema ->- massive appetite suppression
It's not about quantity. It's pharmacodynamics.
Based on my own experience and on more than 50 clients I've worked with in the past years on GLP-1/GIP/GCGR therapies, the pattern is very consistent:
RETAa = best for metabolic shift, fat loss and HbA1c reduction
SEMA = strongest for appetite suppression
Microdosing SEMA on top of RETA = the ideal solution once RETA stops suppressing appetite
If anyone wants deeper guidance on GLP-1/GIP/GCGR protocols, fat loss strategies, performance setups or blood work interpretation, feel free to reach out. I do it professionally
I don't think tirz has all the same health benefits
Your issue is not primarily a GLP-1 receptor problem. Its a combination of elevated evening cortisol, disrupted circadian rhythm, poor sleep architecture, and compulsive nighttime feeding behavior.
