Janoshik Interview

[UncleBuns]

Does that require a cell signal for the entire drive?

Youtube used to allow downloading videos on your phone if you had their premium service. Not sure if that's the case anymore as I haven't paid for YouTube in a long time.

If the interview has been put out as a podcast then most common podcast apps let you download the episode. I download all my podcasts on wifi and can listen to them with no cell service.

 

[rafiki2378]

Great video! I saw it, and it was nice to put a face behind the lab we so often send to for testing. His heart seems to be in the right place too which is always nice! Also was not aware he went through medical school.

 

[ericwoolf]

我的所有产品都送往 janoshik 进行检验

 

[Sheldor]

Finally a face to the reports

 

[TheDieselZ]

That is so cool to be able to put a face to the name finally.

 

[eryximachus]

Wow. He says trenbolone should have the same color as everything else.

 

[PiscesMoon]

Here is a new interview with @janoshik on YouTube, uploaded on August 24th, 2025.

Janoshik PepTok Interview (48:58 runtime)


View: https://www.youtube.com/watch?v=shgk3-u51Ys

 

[Ateam2023]

Here is a new interview with @janoshik on YouTube, uploaded on August 24th, 2025.

Janoshik PepTok Interview (48:58 runtime)


View: https://www.youtube.com/watch?v=shgk3-u51Ys

Thank you @PiscesMoon , that was very informative,,

 

[PiscesMoon]

Thank you @PiscesMoon , that was very informative,,

You're welcome, and agreed! Wish it was longer. Here's hoping they may some day have the "Part 2"

 

[Dav1D3XT]

You're welcome, and agreed! Wish it was longer. Here's hoping they may some day have the "Part 2"

the goat has now a face we can clearly identify

 

[wqihuihukwqeihu21]

Most interesting statement in that interview in my opinion is the discovery of how stable peptides are, at least in powder form, after months and years.

 

[Ghoul]

Most interesting statement in that interview in my opinion is the discovery of how stable peptides are, at least in powder form, after months and years.

You know samples are filtered first, removing the aggregates that are a major indicator of peptide degradation right?

HPLC only detects gross fragmentation or shifts in retention time. Subtle chemical changes, oxidation, deamidation, or epimerization, won’t appear, yet can ruin activity.

That’s why regulations require pharma to pair HPLC with particle analysis, MS and / or bioassays.

 

[dinfaralt]

You know samples are filtered first, removing the aggregates that are a major indicator of peptide degradation right?

HPLC only detects gross fragmentation or shifts in retention time. Subtle chemical changes, oxidation, deamidation, or epimerization, won’t appear, yet can ruin activity.

That’s why regulations require pharma to pair HPLC with particle analysis, MS and / or bioassays.

i work in novo

our qc departments has like 10 hplc-dad machines, 5 UHPLC, 5 HPLC-RI and only 2 GC-MSD machines.

they run everything through filter before testing but its novo man we have CO2 reduced concrete in our buildings to ensure quality. theres no guarantee the china company has filtered so its rather a user should do problem than anyting wrong with janoshik.

its industry standards

 

[Thecarrier]

It would have been interesting to ask during the itw why there is such difference on test report between jano and the other company. I saw recently on aasraw, a result of tren E and like there was a 10% difference on purity (lower of course) with the others. It is not a small gap.

 

[janoshik]

You know samples are filtered first, removing the aggregates that are a major indicator of peptide degradation right?

I don't think implying all aggregates and bigger than 0.22 um is anywhere near true.

HPLC only detects gross fragmentation or shifts in retention time. Subtle chemical changes, oxidation, deamidation, or epimerization, won’t appear

This is extreme falsehood.

That’s why regulations require pharma to pair HPLC with particle analysis, MS and / or bioassays.

Could you point me to, for example, somatropin monograph requiring so?
LCMS is basically unheard of in pharmacopeia. Bioassay is used exactly once in qualifying the product and particle analysis is not conducted in any manner other than dimer and aggregate analysis of *filtered* preparation. As far as I can tell.

Thank you.

 

[Rido]

I don't think implying all aggregates and bigger than 0.22 um is anywhere near true.


This is extreme falsehood.


Could you point me to, for example, somatropin monograph requiring so?
LCMS is basically unheard of in pharmacopeia. Bioassay is used exactly once in qualifying the product and particle analysis is not conducted in any manner other than dimer and aggregate analysis of *filtered* preparation. As far as I can tell.

Thank you.

but the interwebz said...

 

[hexagonal]

I don't think implying all aggregates and bigger than 0.22 um is anywhere near true.


This is extreme falsehood.


Could you point me to, for example, somatropin monograph requiring so?
LCMS is basically unheard of in pharmacopeia. Bioassay is used exactly once in qualifying the product and particle analysis is not conducted in any manner other than dimer and aggregate analysis of *filtered* preparation. As far as I can tell.

Thank you.

I certainly won't claim to be an expert, but it does look like in the US at least, the monograph does include bioassays for either the bulk or prepared material. It's possible I'm misinterpreting this, as it's just my googling.

https://www.drugfuture.com/Pharmacopoeia/usp38/data/v38332/usp38nf33s2_c126.html

https://downloads.regulations.gov/FDA-2004-P-0214-0008/attachment_1.pdf

 

[dinfaralt]

I certainly won't claim to be an expert, but it does look like in the US at least, the monograph does include bioassays for either the bulk or prepared material. It's possible I'm misinterpreting this, as it's just my googling.

https://www.drugfuture.com/Pharmacopoeia/usp38/data/v38332/usp38nf33s2_c126.html

https://downloads.regulations.gov/FDA-2004-P-0214-0008/attachment_1.pdf

just clicking on the stuff you're linking. its talking about hgh bioassays in vivo? where did you read about hgh requiring bioassays?

it might be true since ghouls ai told him

 

[hexagonal]

just clicking on the stuff you're linking. its talking about hgh bioassays in vivo? where did you read about hgh requiring bioassays?

it might be true since ghouls ai told him

Those are docs for the somatropin usp monograph, which outline the standards/testing for those standards/etc. required for it.

 

[dinfaralt]

Those are docs for the somatropin usp monograph, which outline the standards/testing for those standards/etc. required for it.

the one where i dont have to download theres nothing useful. im not downloading anything xd