Janoshik Interview

Does that require a cell signal for the entire drive?
Youtube used to allow downloading videos on your phone if you had their premium service. Not sure if that's the case anymore as I haven't paid for YouTube in a long time.

If the interview has been put out as a podcast then most common podcast apps let you download the episode. I download all my podcasts on wifi and can listen to them with no cell service.
 
Great video! I saw it, and it was nice to put a face behind the lab we so often send to for testing. His heart seems to be in the right place too which is always nice! Also was not aware he went through medical school.
 
Most interesting statement in that interview in my opinion is the discovery of how stable peptides are, at least in powder form, after months and years.

You know samples are filtered first, removing the aggregates that are a major indicator of peptide degradation right?

HPLC only detects gross fragmentation or shifts in retention time. Subtle chemical changes, oxidation, deamidation, or epimerization, won’t appear, yet can ruin activity.

That’s why regulations require pharma to pair HPLC with particle analysis, MS and / or bioassays.
 
You know samples are filtered first, removing the aggregates that are a major indicator of peptide degradation right?

HPLC only detects gross fragmentation or shifts in retention time. Subtle chemical changes, oxidation, deamidation, or epimerization, won’t appear, yet can ruin activity.

That’s why regulations require pharma to pair HPLC with particle analysis, MS and / or bioassays.
i work in novo

our qc departments has like 10 hplc-dad machines, 5 UHPLC, 5 HPLC-RI and only 2 GC-MSD machines.

they run everything through filter before testing but its novo man we have CO2 reduced concrete in our buildings to ensure quality. theres no guarantee the china company has filtered so its rather a user should do problem than anyting wrong with janoshik.

its industry standards
 
It would have been interesting to ask during the itw why there is such difference on test report between jano and the other company. I saw recently on aasraw, a result of tren E and like there was a 10% difference on purity (lower of course) with the others. It is not a small gap.
 
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