I use one spike for the life of the vial.
You attach the luer lock syringe, draw, then disconnect the syringe, leaving the spike in the vial and attach needle. An added benefit is that it prevents using a separate needle to draw, or dulling the needle if using the same to draw and inject.
The model I use has a valve that closes when the syringe is removed, so nothing leaks from the vial being held upside down.
There's a vent that allows air into the vial as you draw, equalizing pressure preventing vacuum from forming.
Liquid flows through a 5 micron particle filter, vent air flows through a 2 micron air filter.
There's a cap that covers the luer connector when not in use.
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