I have not seen that, I will do more research on that then.
Arimidex is an AI, and Nolva a SERM, I am seeing Arimidex is last case if Nolva does not clear up gyno symptoms during cycle. It's not necessary, from what I have gathered, to take either during a simple cycle, unless symptoms pop up.
What do you think?
Yea I haven't had to take nolva yet but in the case where gyno had occurred I was not taking any chances.
This is taken from Reddit
Q: Can Nolvadex (Tamoxifene) and Arimidex (Anastrozole) be used together?
There is a lot of confusing information on wether or not these two compounds can be ran together. Looking at drug interaction charts, Medscape
has the following:
tamoxifen + anastrozole
tamoxifen decreases levels of anastrozole by unspecified interaction mechanism. High likelihood serious or life-threatening interaction. Contraindicated unless benefits outweigh risks and no alternatives available. Never use combination. Anastrozole and tamoxifen should not be administered together.
This information has been contradicted by a few studies.
The effect of anastrozole on the pharmacokinetics of tamoxifen in post-menopausal women with early breast cancer
In conclusion, the results of this study confirm that anastrozole does not affect the pharmacokinetics of tamoxifen when the two drugs are given in combination to post-menopausal women with early breast cancer. In addition, the oestradiol suppressant effects of anastrozole appear unaffected by tamoxifen.
Institute of Cancer Research Repository - Pharmacokinetics of anastrozole and tamoxifen alone, and in combination, during adjuvant endocrine therapy for early breast cancer in postmenopausal women: a sub-protocol of the 'Arimidex (TM) and Tamoxifen Alone or in Combination' (ATAC) trial
As a result of (a) the lack of effect of anastrozole on tamoxifen and DMT levels and (b) the observed fall in blood anastrozole levels having no significant effect on oestradiol suppression by anastrozole, we conclude that the observed reduction in anastrozole levels by tamoxifen is unlikely to be of clinical significance when anastrozole and tamoxifen are administered together.
The actual https://mywebspace.wisc.edu/lbjohnson2/Reading%20List/ATAC.pdf that this information comes from. Pharmacokinetic details can be found
here
http://www.nature.com/bjc/journal/v85/n3/pdf/6691925a.pdf
"...the observed fall in blood anastrozole levels having no significant effect on oestradiol suppression by anastrozole, we conclude that the observed reduction in anastrozole levels by tamoxifen is unlikely to be of clinical significance when anastrozole and tamoxifen are administered together."*
A: Taking arimidex with tamoxifen decreases the serum concentration of anastrozole by 27%, but has no effect on the pharmacodynamics of either