2pac
New Member
Apparently nolvadex and arimadex cant be run together, so played it safe and went for aromasin
MESO-Rx
Anabolic Steroids
15 week test e 500 mg
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Apparently nolvadex and arimadex cant be run together, so played it safe and went for aromasin
Meow Gruber
New Member
I have not seen that, I will do more research on that then.
Arimidex is an AI, and Nolva a SERM, I am seeing Arimidex is last case if Nolva does not clear up gyno symptoms during cycle. It's not necessary, from what I have gathered, to take either during a simple cycle, unless symptoms pop up.
What do you think?
2pac
New Member
Yea I haven't had to take nolva yet but in the case where gyno had occurred I was not taking any chances.
This is taken from Reddit
Q: Can Nolvadex (Tamoxifene) and Arimidex (Anastrozole) be used together?
There is a lot of confusing information on wether or not these two compounds can be ran together. Looking at drug interaction charts, Medscape has the following:
tamoxifen + anastrozole
tamoxifen decreases levels of anastrozole by unspecified interaction mechanism. High likelihood serious or life-threatening interaction. Contraindicated unless benefits outweigh risks and no alternatives available. Never use combination. Anastrozole and tamoxifen should not be administered together.
This information has been contradicted by a few studies.
The effect of anastrozole on the pharmacokinetics of tamoxifen in post-menopausal women with early breast cancer
In conclusion, the results of this study confirm that anastrozole does not affect the pharmacokinetics of tamoxifen when the two drugs are given in combination to post-menopausal women with early breast cancer. In addition, the oestradiol suppressant effects of anastrozole appear unaffected by tamoxifen.
http://publications.icr.ac.uk/629/ (Institute of Cancer Research Repository - Pharmacokinetics of anastrozole and tamoxifen alone, and in combination, during adjuvant endocrine therapy for early breast cancer in postmenopausal women: a sub-protocol of the 'Arimidex (TM) and Tamoxifen Alone or in Combination' (ATAC) trial)
As a result of (a) the lack of effect of anastrozole on tamoxifen and DMT levels and (b) the observed fall in blood anastrozole levels having no significant effect on oestradiol suppression by anastrozole, we conclude that the observed reduction in anastrozole levels by tamoxifen is unlikely to be of clinical significance when anastrozole and tamoxifen are administered together.
The actual https://mywebspace.wisc.edu/lbjohnson2/Reading%20List/ATAC.pdf that this information comes from. Pharmacokinetic details can be found here
http://www.nature.com/bjc/journal/v85/n3/pdf/6691925a.pdf
"...the observed fall in blood anastrozole levels having no significant effect on oestradiol suppression by anastrozole, we conclude that the observed reduction in anastrozole levels by tamoxifen is unlikely to be of clinical significance when anastrozole and tamoxifen are administered together."*
A: Taking arimidex with tamoxifen decreases the serum concentration of anastrozole by 27%, but has no effect on the pharmacodynamics of either
2pac
New Member
22nd of November
Pin 21: left thigh
Starting to get spots on arm
23rd of November.
So I have been advised by my coach and people on here to cut the cycle short at 12 weeks so I will be doing that and instead of pct I will be cruising on around 250mg a week. I will then be doing another blast in a few months and making a new log (anadrol test tren)
Pin 21: left thigh
Starting to get spots on arm
23rd of November.
So I have been advised by my coach and people on here to cut the cycle short at 12 weeks so I will be doing that and instead of pct I will be cruising on around 250mg a week. I will then be doing another blast in a few months and making a new log (anadrol test tren)
2pac
New Member
So I have around 2 weeks left finishing on 19th of December. I will then post some progress pics.
2pac
New Member
25th of November
Pin 22: Right delt
Fuck me that was sore. I think I injected to fast because as I was pushing the last bits in it became excruciating. Is very sore now as if I've been stabbed.
28th of november
Pin 23: right thigh
Was going to dl other shoulder but don't want to impede workout.
Up a total of 8kg so far. Quite happy with the results thus far.
Pin 22: Right delt
Fuck me that was sore. I think I injected to fast because as I was pushing the last bits in it became excruciating. Is very sore now as if I've been stabbed.
28th of november
Pin 23: right thigh
Was going to dl other shoulder but don't want to impede workout.
Up a total of 8kg so far. Quite happy with the results thus far.
