24k Pharma US Domestic Source

Appreciate the response. Pharma patenting is absolutely ridiculous.

Yes and no. If you invested BILLIONS (with a B) into developing a new drug, and then getting it passed through all the red tape and government BS, you'd expect to be able to then recoup that investment in somewhat of a timely manner. By preventing generic companies from copying the drug right away, you are allowing the company that took all of the financial risk (and expenditure of cash that could have been being used for other purposes) to recoup that investment.

As a consumer, it does suck not to have a generic alternative for a while, but not having some of these drugs developed in the first place, would suck more.

And, no, I do not work for a pharmaceutical company! ;)
 
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Yes and no. If you invested BILLIONS (with a B) into developing a new drug, and then getting it passed through all the red tape and government BS, you'd expect to be able to then recoup that investment in somewhat of a timely manner. By preventing generic companies from copying the drug right away, you are allowing the company that took all of the financial risk (and expenditure of cash that could have been being used for other purposes) to recoup that investment.

As a consumer, it does suck not to have a generic alternative for a while, but not having some of these drugs developed in the first place, would suck more.

And, no, I do not work for a pharmaceutical company! ;)

I found out something quite interesting from my cousin who works for a pharmaceutical company. We were at dinner at our aunt's house and somehow the topic of brand names and genetics came up. He wasn't aware of this until just recently but he told us that genetics are allowed a +/- 20% variability in potency from the brand name/original drug and still be within FDA guidelines.

I've experienced this myself with heart burn meds. When I was on brand name Prilosec, I could drink hot sauce out the bottle and never get any heartburn. Any of my trigger foods regardless of the quantities consumed wouldn't aggravate the heart burn. Recently I've tried generic omeprazole from walmart and another company and I'm getting flare ups pretty regularly and that's with dietary adjustments.
 
I found out something quite interesting from my cousin who works for a pharmaceutical company. We were at dinner at our aunt's house and somehow the topic of brand names and genetics came up. He wasn't aware of this until just recently but he told us that genetics are allowed a +/- 20% variability in potency from the brand name/original drug and still be within FDA guidelines.

I've experienced this myself with heart burn meds. When I was on brand name Prilosec, I could drink hot sauce out the bottle and never get any heartburn. Any of my trigger foods regardless of the quantities consumed wouldn't aggravate the heart burn. Recently I've tried generic omeprazole from walmart and another company and I'm getting flare ups pretty regularly and that's with dietary adjustments.
Shit! I was filling Prescript Prilosec. Went to the equate omep and withing a few months I was doubling the dose. Thought I was getting worse. That maybe but maybe the generic is an underdosed POS.
 
Shit! I was filling Prescript Prilosec. Went to the equate omep and withing a few months I was doubling the dose. Thought I was getting worse. That maybe but maybe the generic is an underdosed POS.

The Equate omeprazole was one of the ones i tried, currently on it now actually, and I feel it's far inferior to real Prilosec.
 
I found out something quite interesting from my cousin who works for a pharmaceutical company. We were at dinner at our aunt's house and somehow the topic of brand names and genetics came up. He wasn't aware of this until just recently but he told us that genetics are allowed a +/- 20% variability in potency from the brand name/original drug and still be within FDA guidelines.

I've experienced this myself with heart burn meds. When I was on brand name Prilosec, I could drink hot sauce out the bottle and never get any heartburn. Any of my trigger foods regardless of the quantities consumed wouldn't aggravate the heart burn. Recently I've tried generic omeprazole from walmart and another company and I'm getting flare ups pretty regularly and that's with dietary adjustments.

It is actually 20% below, and 25% above. And it has to do with bio-equivalence. Many generics test well above the brands so it is not that they are always less potent. They are given a range to fall within.

If you have trouble with a particular generic brand, switch to another one if possible. Sticking to brands like Teva, Mylan, PAR, Sandoz etc will often times be a safe bet.
 
I found out something quite interesting from my cousin who works for a pharmaceutical company. We were at dinner at our aunt's house and somehow the topic of brand names and genetics came up. He wasn't aware of this until just recently but he told us that genetics are allowed a +/- 20% variability in potency from the brand name/original drug and still be within FDA guidelines.

I've experienced this myself with heart burn meds. When I was on brand name Prilosec, I could drink hot sauce out the bottle and never get any heartburn. Any of my trigger foods regardless of the quantities consumed wouldn't aggravate the heart burn. Recently I've tried generic omeprazole from walmart and another company and I'm getting flare ups pretty regularly and that's with dietary adjustments.

Technically, it is the generics pharmacokinetic AUC and Cmax that must fall within 80% and 125% of the brand names.
 
I found out something quite interesting from my cousin who works for a pharmaceutical company. We were at dinner at our aunt's house and somehow the topic of brand names and genetics came up. He wasn't aware of this until just recently but he told us that genetics are allowed a +/- 20% variability in potency from the brand name/original drug and still be within FDA guidelines.

I've experienced this myself with heart burn meds. When I was on brand name Prilosec, I could drink hot sauce out the bottle and never get any heartburn. Any of my trigger foods regardless of the quantities consumed wouldn't aggravate the heart burn. Recently I've tried generic omeprazole from walmart and another company and I'm getting flare ups pretty regularly and that's with dietary adjustments.

Interesting.... So there is some truth in a member saying brand name Vicodin is more potent than generics.
 
I always liked the "M box" roxy 30s and a few other good ones. The generics (224s, blanks, etc) all tasted shitty and never seemed as good.

Edit: And I don't even need to mention old school OxyContin..
 
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Interesting.... So there is some truth in a member saying brand name Vicodin is more potent than generics.

Fuck yeah there's truth to it. Any ex-addict knows this. My dads valiums with the heart cut out in them that actually said Valium on then was way more superior then just the blue round ones that said they were the same mg. Same goes for Vicodin and Xanax. There's a reason people pay up to 4x as much for them instead of just buying generics. What's funny is when I mentioned this before the same member that called my claims false is now coming in and saying it's true. Lol weird, it must only apply to heart burn meds :rolleyes:
 
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Fuck yeah there's truth to it. Any ex-addict knows this. My dads valiums with the heart cut out in them that actually said Valium on then was way more superior then just the blue round ones that said they were the same mg. Same goes for Vicodin and Xanax. There's a reason people pay up to 4x as much for them instead of just buying generics. What's funny is when I mentioned this before the same member that called my claims false is now coming in and saying it's true. Lol weird, it must only apply to heart burn meds :rolleyes:
That is true. Nothing compares to brand name. I am a recovering addict and have taken my fair share of everything. And when it came to generics vs brand name I could tell. So many old timers would say the same. Nothing compared to the original.
 
Fuck yeah there's truth to it. Any ex-addict knows this. My dads valiums with the heart cut out in them that actually said Valium on then was way more superior then just the blue round ones that said they were the same mg. Same goes for Vicodin and Xanax. There's a reason people pay up to 4x as much for them instead of just buying generics. What's funny is when I mentioned this before the same member that called my claims false is now coming in and saying it's true. Lol weird, it must only apply to heart burn meds :rolleyes:

I am also a recovering pill junkie. My junkie ass eat them all. I didn't give a fuck as long as I had a handful for the next morning. I used to drive across state (5hrs) to pick up few pills and would get mentally withdrawals be the time I made it back home. I'd did some crazy shit to get my fix. Opiate withdrawls were/is/will be awful.
 
I am also a recovering pill junkie. My junkie ass eat them all. I didn't give a fuck as long as I had a handful for the next morning. I used to drive across state (5hrs) to pick up few pills and would get mentally withdrawals be the time I made it back home. I'd did some crazy shit to get my fix. Opiate withdrawls were/is/will be awful.
Hate em. Hate em so damn much.
 
man, i thought it was just me. i used brand name tramadols and then got some generics and there was a definite difference, i was up to 40 pills a day at one point and id say if they were the brand name ones ida been dead from serotonin syndrome seizures. there were nights id literally spasm and spring up off the bed. either way, quitting vicodins and trams was hell regardless of the brand.
 
man, i thought it was just me. i used brand name tramadols and then got some generics and there was a definite difference, i was up to 40 pills a day at one point and id say if they were the brand name ones ida been dead from serotonin syndrome seizures. there were nights id literally spasm and spring up off the bed. either way, quitting vicodins and trams was hell regardless of the brand.
Jesus that sounds terrible. Like fuck if you're gonna abuse drugs at least abuse the good ones.. Tramadol is a terrible drug.
 
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