A sober look at HGH

[bananafeet]

Typical hyperglycemia isn't a risk factor for T2DM, it is T2DM

But the evidence claimed by the source you posted doesn't provide any data showing GH-induced insulin resistance is permanent

From: Incidence of diabetes mellitus and impaired glucose tolerance in children and adolescents receiving growth-hormone treatment

"By contrast, we found that the incidence of type 2 diabetes mellitus was six-fold higher in children treated with GH compared with the incidence in two studies of age-matched untreated children.7,13 There are several possible explanations to account for the high incidence of type 2 diabetes mellitus with GH treatment. Although type 2 diabetes mellitus is thought to be rare in childhood and adolescence, there has been a substantial increase in the incidence of this disorder in the past few years.7,13 GH therapy may also have hastened the onset of type 2 diabetes that would have occurred in adult life without GH therapy. The persistence of diabetes mellitus after GH therapy was stopped excludes a transient drug-induced effect such as that seen with high dose glucocorticoid treatment.3 There are several sites in the insulin-signalling pathway at which GH can induce anti-insulin effects.15 In acromegaly, high GH concentrations are sustained for years and the frequency of diabetes mellitus in these patients is 13–27%.16,17 We speculate that conventional GH therapy alone is unlikely to initiate a new case of type 2 diabetes mellitus. Unlike patients with acromegaly, the children who developed type 2 diabetes received low doses of GH for far fewer years. In short, normal, prepubertal children, 2 years of high-dose GH therapy reduced insulin sensitivity and increased serum insulin concentrations but glucose intolerance did not occur."

Still inconclusive. 6 fold doesn't sound good tho lol

 

[bananafeet]

Skeletal muscle is a metabolically active tissue, which accounts for more than 80% of the variation in oxygen consumption during rest. The role of the GH-IGF axis for protein anabolism including muscle growth is also obvious when considering the phenotypes of GH deficiency and acromegaly. Growth hormone substitution in GHDA is associated with a 5–10% increase in muscle volume as assessed by either computed tomography (CT) or dual-energy X-ray absorptiometry (DEXA) scanning [24]. This GH action involves increased protein synthesis and reduced protein breakdown and is mediated both by GH itself and IGF-1. It should, however, be considered that part of this increase includes rehydration. Another important interaction between muscle metabolism and GH is insulin-stimulated glucose disposal. Administration of GH into the brachial artery acutely suppresses insulin-stimulated glucose uptake across the forearm [5].This is accompanied by a concomitant increase in FFA uptake compatible with the lipolytic effects of GH [2]. This is noteworthy, as FFA for many years have been implicated in the development of insulin resistance. It was originally suggested by Randle et al. that increased FFA flux into muscle inhibited glycolysis by means of simple substrate competition [32]. More recent studies in humans suggest that FFA may interfere with insulin signaling and in particular may suppress PI3 kinase activity, which is considered essential for the recruitment and functioning of GLUT4 [8]. By contrast, Jessen et al. did not record any impact of GH on insulin-stimulated PI3 kinase activity in healthy individuals despite the fact that GH was associated with increased FFA levels as well as insulin resistance [9]. It has, however, been shown that GH-induced insulin resistance is associated with accumulation of intramyocellular fat [6] in resemblance with more common conditions of insulin resistance, such as the metabolic syndrome. Moreover, we have been unable to document evidence of crosstalk between the signaling pathways of insulin and GH, respectively [10, 18]. The molecular mechanisms whereby GH causes insulin resistance in muscle therefore remain to be explained.

Source: Effects of GH in human muscle and fat (attached)

 

[strixsir]

From: Incidence of diabetes mellitus and impaired glucose tolerance in children and adolescents receiving growth-hormone treatment


Still inconclusive. 6 fold doesn't sound good tho lol

People simply are coping that HGH does didly dick for actual contractile tissue unless you mix in insulin with copious amount of AAS load and have the genetics for grow from anything.

decade long facade.

 

[Billbo98]

People simply are coping that HGH does didly dick for actual contractile tissue unless you mix in insulin with copious amount of AAS load and have the genetics for grow from anything.

decade long facade.

Bro you have a big mouth for a guy who suggests test prop as a 1st cycle to a noob. You sound quite autistic if I may say so myself.

 

[bananafeet]

Bro you have a big mouth for a guy who suggests test prop as a 1st cycle to a noob. You sound quite autistic if I may say so myself.

Fight fight fight!

I need my entertainment.

 

[Billbo98]

Fight fight fight!

I need my entertainment.

Pretty sure hes some Indian kid who stays watching Kurt havens and Vig Steve and Tanner Faggad and spews that bs here in his posts

 

[bananafeet]

Pretty sure hes some Indian kid who stays watching Kurt havens and Vig Steve and Tanner Faggad and spews that bs here in his posts

My current cycle is sponsored by that subcontinent haha

It's good to see people passionate about a subject.

I'm just trying to figure out how I can run all this HGH safely. Couldn't care less about who's right/wrong etc

Youtube was the worst thing to happen to bodybuilding

 

[Billbo98]

My current cycle is sponsored by that subcontinent haha

It's good to see people passionate about a subject.

I'm just trying to figure out how I can run all this HGH safely. Couldn't care less about who's right/wrong etc

Youtube was the worst thing to happen to bodybuilding

My brotha. Carb cycle with 2 low days a week and use Metformin ER 500AM & PM and do 30mins cardio 5-7 days a week. Always keeps me anywhere from 70-90 on the glucometer depending how late I ate and took my bolus night before.

 

[bananafeet]

Goal: lose fat and gain muscle

Me:

 

[strixsir]

Pretty sure hes some Indian kid who stays watching Kurt havens and Vig Steve and Tanner Faggad and spews that bs here in his posts

we are the same age.

Bro you have a big mouth for a guy who suggests test prop as a 1st cycle to a noob. You sound quite autistic if I may say so myself.

i am actually somewhat autistic ( no joke)

 

[Billbo98]

Goal: lose fat and gain muscle

Me:
View attachment 380520

Hahahahaha I love Charlie bro! My wife was joking around saying I can’t do the dishes because that’s her Charlie work hahahahaha

 

[Billbo98]

we are the same age.


i am actually somewhat autistic ( no joke)

Who is the same age? And yeah that’s why I said it I can def tell the spectrum is strong with this one.

 

[ThinBulk]

My current cycle is sponsored by that subcontinent haha

It's good to see people passionate about a subject.

I'm just trying to figure out how I can run all this HGH safely. Couldn't care less about who's right/wrong etc

Youtube was the worst thing to happen to bodybuilding

My last post addressed a few functional things like timing of bolus, carb load, and activity. You haven't looked for how to make it work at all. It only sounds like trying to band everyone with bad blood sugar control together.

There are 20 different things you can do to get your insulin resistance under control. If not, GH isn't for you.

 

[bananafeet]

My last post addressed a few functional things like timing of bolus, carb load, and activity. You haven't looked for how to make it work at all. It only sounds like trying to band everyone with bad blood sugar control together.

There are 20 different things you can do to get your insulin resistance under control. If not, GH isn't for you.

Maybe. Have you even read what I posted or are you just quoting what everyone else says?

 

[ThinBulk]

Maybe. Have you even read what I posted or are you just quoting what everyone else says?

I read it all. GH is great, but the same as any other drug here. You need to do extra to create the environment where you arent crippled by avoidle side effects. It's like saying AAS are all shit because your blood pressure is 180/95 now. Showing studies on how AAS have a bad effect on blood pressure doesn't mean AAS don't work.

I hope you take this the right way. GH has more going on than taking test. You personally have factors creating bad blood sugar control. Until you're willing to address those, it's just not for you.

 

[bananafeet]

I read it all. GH is great, but the same as any other drug here. You need to do extra to create the environment where you arent crippled by avoidle side effects. It's like saying AAS are all shit because your blood pressure is 180/95 now. Showing studies on how AAS have a bad effect on blood pressure doesn't mean AAS don't work.

I hope you take this the right way. GH has more going on than taking test. You personally have factors creating bad blood sugar control. Until you're willing to address those, it's just not for you.

When I take testosterone I'm taking something that directly stimulates muscle protien synthesis.

That doesn't mean if it raises my blood pressure it doesn't work. That would be a side effect. Something to the side of the effect I want.

However raising my blood glucose is HGH working. It's the literal effect of the drug by stimulating FFA release and by increasing gluconeogenesis in the liver (and my reducing GLUT4 sensitivity in the muscle tissue).

Now you're saying because I can't manage this or don't like it somehow I'm not using the drug properly.

What I am saying is:
Given the effect of HGH is to create a diabetogenic state I don't see how the minor gain in anabolism justifies the risk for me.

It will do this to everyone. You can take drugs to offset this (polypharmacy), but in the end unless you have GH deficiency it will harm your health long term.

HGH is very profitable for these companies. If it had any use outside the very narrow scope it's being used for now they WOULD have pushed for it.

 

[Sampei]

When I take testosterone I'm taking something that directly stimulates muscle protien synthesis.

That doesn't mean if it raises my blood pressure it doesn't work. That would be a side effect. Something to the side of the effect I want.

However raising my blood glucose is HGH working. It's the literal effect of the drug by stimulating FFA release and by increasing gluconeogenesis in the liver (and my reducing GLUT4 sensitivity in the muscle tissue).

Now you're saying because I can't manage this or don't like it somehow I'm not using the drug properly.

What I am saying is:
Given the effect of HGH is to create a diabetogenic state I don't see how the minor gain in anabolism justifies the risk for me.

It will do this to everyone. You can take drugs to offset this (polypharmacy), but in the end unless you have GH deficiency it will harm your health long term.

HGH is very profitable for these companies. If it had any use outside the very narrow scope it's being used for now they WOULD have pushed for it.

I mean we are on a steroid boards, almost everything we take harms our body.

Your logic makes zero sense in so many ways. Plus you have zero real experience or understanding of HGH and you just keep reading studies and books that sure are a very important piece of info but needs to be accompanied by real world facts and use, specifically tailored to the individual and his current state.

Can HGH get you to be in a pre diabetic status? Sure. Is there like 10+ ways to avoid this? Yes there are. Is this worth it? Depends on the personal goal of a person and what he wants to achieve.

Is it good to use HGH if you have already a compromised insulin sensitivity like yourself? Nope it is not.

I have labs with perfect insulin sensitivity and an average BG of 85 and hb1ac of 5/5.2 triglycerides around 45/55 and insulin levels low as fuck using 12/14IU of HGH daily for months and an igf1 of 380/350 so not even crazy high.

Sides? Close to zero. Benefits? Plenties.

Would I suggest the same to anyone? Nope, as everything needs to be tailored to the person and his/her response to the drugs.

 

[strixsir]

I mean we are on a steroid boards, almost everything we take harms our body.

Your logic makes zero sense in so many ways. Plus you have zero real experience or understanding of HGH and you just keep reading studies and books that sure are a very important piece of info but needs to be accompanied by real world facts and use, specifically tailored to the individual and his current state.

Can HGH get you to be in a pre diabetic status? Sure. Is there like 10+ ways to avoid this? Yes there are. Is this worth it? Depends on the personal goal of a person and what he wants to achieve.

Is it good to use HGH if you have already a compromised insulin sensitivity like yourself? Nope it is not.

I have labs with perfect insulin sensitivity and an average BG of 85 and hb1ac of 5/5.2 triglycerides around 45/55 and insulin levels low as fuck using 12/14IU of HGH daily for months and an igf1 of 380/350 so not even crazy high.

Sides? Close to zero. Benefits? Plenties.

Would I suggest the same to anyone? Nope, as everything needs to be tailored to the person and his/her response to the drugs.

i know its about the Z score when talking about IGF-1 but I am quite curios how come your IGF1 at 12-14 IU is at 380/350?

i have a small sample size of 6 people who had IGF1 in 500s at just 2 IU daily.

 

[bananafeet]

I mean we are on a steroid boards, almost everything we take harms our body.

Your logic makes zero sense in so many ways. Plus you have zero real experience or understanding of HGH and you just keep reading studies and books that sure are a very important piece of info but needs to be accompanied by real world facts and use, specifically tailored to the individual and his current state.

Can HGH get you to be in a pre diabetic status? Sure. Is there like 10+ ways to avoid this? Yes there are. Is this worth it? Depends on the personal goal of a person and what he wants to achieve.

Is it good to use HGH if you have already a compromised insulin sensitivity like yourself? Nope it is not.

I have labs with perfect insulin sensitivity and an average BG of 85 and hb1ac of 5/5.2 triglycerides around 45/55 and insulin levels low as fuck using 12/14IU of HGH daily for months and an igf1 of 380/350 so not even crazy high.

Sides? Close to zero. Benefits? Plenties.

Would I suggest the same to anyone? Nope, as everything needs to be tailored to the person and his/her response to the drugs.

Thanks for commenting Sampei I always enjoy reading your posts.

Everyone responds differently. My igf1 got that high on 2iu of HGH per day. I guess it's individual sensitivity.

Glad it's working for you.

 

[BendigoShafter]

i know its about the Z score when talking about IGF-1 but I am quite curios how come your IGF1 at 12-14 IU is at 380/350?

i have a small sample size of 6 people who had

Cuz everyone is different.

I'm testing between 300-350 ng/mL on 4iu per day so my numbers don't match your cohort or @Sampei


Re: Z score....

The IGF-1 ng/mL number is really the most important part. The Z score is derived directly from it and just tells you how many standard deviations you are from from average. Z score of 1.0 is average, Z score of 2.0 is +1SD, 3.0 is +2SD, etc.

Assuming standard IGF-1 distributions, Z score of 3.0 (our semi-arbitrary warning level) would mean that you had higher IGF-1 levels than about 95% of the population.