Androgens and acid reflux, peptic ulcer

[Pulpfiction]

Yeah this is what happened to me, got pancreatitis due to gear and ever since my stomach/gut issues have been severe when I run gear. My last run w tren was a few mi the ago, even at 200 my stomach can’t handle it, mostly pain in the liver/tightness in stomach. Stopping pre workout helped massively but certain orals, if I don’t take a long enough break in between, will set my GI issues back up. Can’t ignore it anymore like I did years ago

 

[Pinnacle Elements]

Yeah this is what happened to me, got pancreatitis due to gear and ever since my stomach/gut issues have been severe when I run gear. My last run w tren was a few mi the ago, even at 200 my stomach can’t handle it, mostly pain in the liver/tightness in stomach. Stopping pre workout helped massively but certain orals, if I don’t take a long enough break in between, will set my GI issues back up. Can’t ignore it anymore like I did years ago

thank you for the honesty and the warning. I will take this into serious consideration.

We’re you running large dosages prior?

 

[Pulpfiction]

thank you for the honesty and the warning. I will take this into serious consideration.

We’re you running large dosages prior?

I mean not really, I think it had to do with running orals for too long and not having proper support supplements. Most I ever ran tren was 350, test I usually go 500, 750 max but it’s been years since I took it that high. Honestly test is fine I never have issues stomach related, it’s when I add a nandrolone and orals. But when I take a long break I’m ok and can run mild orals for no more than 6 weeks. Winny I’ve never gone above 50 a day and tbol 50 a day. Stomach is just extra sensitive now

 

[Type-IIx]

I am not sure of the physiological mechanism by which AAS seem to increase the rate of acid reflux symptoms - but yes. That is definitely my experience - and Tren and most orals seem to do so more than other AAS ("the injectables").

@Type-IIx - do you happen to have any thoughts on PPIs and how they might impact androgens and estrogens? From re-reading the threads, it seems an H2 blocker would be preferred?

I prefer H2R antagonists ("H2 blockers") because the proton pump inhibitors (PPIs): e.g., esomeprazole (Nexium), lansoprazole (Prevacid), and omeprazole (Prilosec), while also effective, work by a different mechanism (irreversibly binding to H⁺/K⁺ ATPase ["proton pump"] in parietal cells).

Using these chronically for as few as 8 weeks (>= 8 weeks), upon cessation, rebound hyperacidity (hypergastrinemia) is likely, therefore PPIs should be slowly tapered. [257], [258]. Other long-term use considerations include risk of fractures, hypomagnesemia, C. diff.-associated diarrhea, vitamin B12 deficiency, pneumonia, acute interstitial nephritis (AIN), cutaneous & systemic lupus erythomatosus (CLE/SLE) events, dementia, & drug interactions... [259].

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