This link has a collection of studies and research that is worth saving.
last update APR-17, 2023 notes on... - TextUp
From that link, here are some prion resources:
PRION DISEASES - PROTECTION and possible TREATMENTS - yogurt, curry and capers]
[2021]
*More context; protective effects of RESVERATROL, LACTOFERRIN, MELATONIN:
Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity - PubMed
Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicit
Jeong et al
Resveratrol initiates neuroprotective effects via the activation of autophagy, which protects organelles, cells, and organisms against misfolded protein-disorders
Melatonin-induced autophagy protects against human prion protein-mediated neurotoxicity - PubMed
Melatonin-induced autophagy protects against human prion protein-mediated neurotoxicity
Jeong et al
protective effect of melatonin against mitochondrial dysfunction was related with autophagy activation.
Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction
Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction
Park et al
These results demonstrated that LF protects neuronal cells against PrP (106-126)-mediated neurotoxicity through the scavenging of ROS and provide evidence that LF treatment prevents neuronal cell death caused by PrP
Lactoferrin decreases LPS-induced mitochondrial dysfunction in cultured cells and in animal endotoxemia model
Lactoferrin decreases LPS-induced mitochondrial dysfunction in cultured cells and in animal endotoxemia model
Kurzel et al
lactoferrin protects against oxidative insult at the mitochondrial level
2022]
*More context; protective effects of QUERCETIN AND CURCUMIN:
Quercetin turns fibrils into protease-sensitive, structurally loose and non-cytotoxic forms
Curcumin Reduces Amyloid Fibrillation of Prion Protein and Decreases Reactive Oxidative Stress
Curcumin Reduces Amyloid Fibrillation of Prion Protein and Decreases Reactive Oxidative Stress
Chi-Fen Lin et al
Quercetin Disaggregates Prion Fibrils and Decreases Fibril-Induced Cytotoxicity and Oxidative Stress - PubMed
Quercetin Disaggregates Prion Fibrils and Decreases Fibril-Induced Cytotoxicity and Oxidative Stress
Kun-Hua Yu, Cheng-I Lee
Quercetin binding accelerates prion fibrillation into proteinase sensitive and loosely structured amyloids
Quercetin binding accelerates prion fibrillation into proteinase sensitive and loosely structured amyloids
Kun-HuaYua et al
[AMYLOIDOSIS - PROTECTION and possible TREATMENTS - yogurt, curry, capers]
[2022]
Quercetin turns fibrils into protease-sensitive, structurally loose and non-cytotoxic forms
Curcumin Reduces Amyloid Fibrillation of Prion Protein and Decreases Reactive Oxidative Stress
Curcumin Reduces Amyloid Fibrillation of Prion Protein and Decreases Reactive Oxidative Stress
Chi-Fen Lin et al
Quercetin Disaggregates Prion Fibrils and Decreases Fibril-Induced Cytotoxicity and Oxidative Stress - PubMed
Quercetin Disaggregates Prion Fibrils and Decreases Fibril-Induced Cytotoxicity and Oxidative Stress
Kun-Hua Yu, Cheng-I Lee
Quercetin binding accelerates prion fibrillation into proteinase sensitive and loosely structured amyloids
Quercetin binding accelerates prion fibrillation into proteinase sensitive and loosely structured amyloids
Kun-HuaYua et al
Natural product-based amyloid inhibitors - PubMed
Natural product-based amyloid inhibitors
Paul Velander 1, Ling Wu 1, Frances Henderson 1, Shijun Zhang 2, David R Bevan 3, Bin Xu 4
[2023]
Quercetin as a possible complementary agent for early-stage COVID-19: Concluding results of a randomized clinical trial
Quercetin as a possible complementary agent for early-stage COVID-19: Concluding results of a randomized clinical trial
Di Pierro et al
Our results, suggest the possible therapeutic role of quercetin in early-stage COVID-19, including speedy clearance of SARS-CoV-2, early resolution of the acute symptoms and modulation of the host’s hyperinflammatory response.
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[AMYLOIDOSIS - ALZHEIMER - infection, spike, treatments]
[CONTEXT]
https://www.researchgate.net/public...ion_of_Amyloid_Formation_in_Aging_and_Disease
https://www.researchgate.net/figure...lded-protein-can-be-refolded-1_fig2_313698560
Neurophage.com
RESVERATROL, LACTOFERRIN, MELATONIN, QUERCETIN and CURCUMIN proved to have PROTECTIVE EFFECTS.
Quercetin binding accelerates prion fibrillation into proteinase sensitive and loosely structured amyloids
Quercetin Disaggregates Prion Fibrils and Decreases Fibril-Induced Cytotoxicity and Oxidative Stress - PubMed
Curcumin Reduces Amyloid Fibrillation of Prion Protein and Decreases Reactive Oxidative Stress
Lactoferrin decreases LPS-induced mitochondrial dysfunction in cultured cells and in animal endotoxemia model
Melatonin-induced autophagy protects against human prion protein-mediated neurotoxicity - PubMed
Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity - PubMed
https://pubmed.ncbi.nlm.nih.gov/28390938
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[PRION DISEASES - ALZHEIMER - infection, spike protein, possible treatments]
[CONTEXT]
*SARS-CoV-2 spike protein is a transmembrane protein, and it contains five GxxxG motifs in its sequence (see uniprot.org/uniprot/P0DTC2), it's extremely plausible that it could behave as a prion.
*Did you know that, back in the Paleolithic, a super-prion pandemic almost wiped out humanity as a whole? Then humans developed a gene that protected against the infection and nowadays confers an slight resistance to other prion diseases. The only people in the world that don't have that gene are the Japanese.
https://pubmed.ncbi.nlm.nih.gov/24398570/
*RESVERATROL, LACTOFERRIN, MELATONIN, QUERCETIN and CURCUMIN proved to have PROTECTIVE EFFECTS.
Quercetin binding accelerates prion fibrillation into proteinase sensitive and loosely structured amyloids
Quercetin Disaggregates Prion Fibrils and Decreases Fibril-Induced Cytotoxicity and Oxidative Stress - PubMed
Curcumin Reduces Amyloid Fibrillation of Prion Protein and Decreases Reactive Oxidative Stress
Lactoferrin decreases LPS-induced mitochondrial dysfunction in cultured cells and in animal endotoxemia model
Melatonin-induced autophagy protects against human prion protein-mediated neurotoxicity - PubMed
Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity - PubMed