Blood work Sema vs Tirz

[Here2Learn]

I know there is the lab results section but it mostly seems for steroid use, which makes sense, so I decided to post here. I will be seeing my PCP next week to follow up on this but curious if anyone has seen similar.

I had blood done in June after starting Sema end of April. Everything was within range except my A1c was borderline at 5.7.

Switched to Tirz 09/20 and had blood done again last week. Now AST(SGOT) is slightly high at 41 u/l, Lymphocytes low at 22.8%. A1c was 5.4 but est average glucose was 108.

I guess my question is why would my liver AST be elevated after moving to Tirz? I have recently started lifting weights again and tracking foods so my protein has increased, diet was mostly clean on both just more protein focused now. Starting to lose faster now.

Sema couldn’t get bigger than 1mg due to exhaustion and titrated up very slowly.

Tirz I’m at 4mg and handle fairly well, added .5mg and now up to .75mg of Reta for energy which has worked well for me. Tirz does not help with my inflammation as well as Sema did so wonder if it comes down to that alone.

Anyway, just curious if others have thoughts/ideas.

 

[Ghoul]

It's caused by Tirz's rapid liver defatting and transient.

Absent of symptoms, it's of no concern.

Tirz isn't hepatoxic and isn't processed by the liver.

 

[Here2Learn]

This has been my suspicion also but didn’t want to assume on my own.

It's caused by Tirz's rapid liver defatting and transient.

Absent of symptoms, it's of no concern.

Tirz isn't hepatoxic and isn't processed by the liver.

 

[Here2Learn]

What do you mean by transient? Defatting I understand but unsure what that means.

 

[Ghoul]

What do you mean by transient? Defatting I understand but unsure what that means.

The rate of defatting is highest at first, decreasing as your liver clears. As you escalate the dose it may jump again, but sooner or later your liver is clear enough there's far less to clear, and enzymes go down. Once you reach a stable maintainance dose, levels should be completely back to baseline or better.

 

[Here2Learn]

The rate of defatting is highest at first, decreasing as your liver clears. As you escalate the dose it may jump again, but sooner or later your liver is clear enough there's far less to clear, and enzymes go down. Once you reach a stable maintainance dose, levels should be completely back to baseline or better.

I think I have a lot of liver defatting in my future if this is doing its job.

 

[Ghoul]

I think I have a lot of liver defatting in my future if this is doing its job.

There's a good chance most of us are walking around with undiagnosed fatty liver disease. Tirz is quietly undermining this epidemic.

Have you checked up on your liver? Diagnosing MASH and steatotic liver disease - Mayo Clinic Press

There are two main types of steatotic liver disease that are unrelated to alcohol consumption —metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) — and both are caused by having too much fat in the liver.

mcpress.mayoclinic.org

 

[Here2Learn]

There's a good chance most of us are walking around with undiagnosed fatty liver disease. Tirz is quietly undermining this epidemic.

Have you checked up on your liver? Diagnosing MASH and steatotic liver disease - Mayo Clinic Press

There are two main types of steatotic liver disease that are unrelated to alcohol consumption —metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) — and both are caused by having too much fat in the liver.

mcpress.mayoclinic.org

I had read up a lot about Tirz positive effects for the liver before starting. While I don’t really get appetite suppression from Tirz and a less inflammation relief I am still like it better and have started losing at a consistent rate.

I honestly feel like I had switched the off button on my body, put it into hibernation mode prior to any GLP’s. My calories were low, my output of calories was low, inflammation was very high and I was just in statis. Sema caused my calories to go lower and I didn’t really loose anything but inflammation. With Tirz I’ve upped my calories and have energy to workout so calories out have increased. Overall feeling much better than I have and weight is decreasing.

 

[Ghoul]

I had read up a lot about Tirz positive effects for the liver before starting. While I don’t really get appetite suppression from Tirz and a less inflammation relief I am still like it better and have started losing at a consistent rate.

I honestly feel like I had switched the off button on my body, put it into hibernation mode prior to any GLP’s. My calories were low, my output of calories was low, inflammation was very high and I was just in statis. Sema caused my calories to go lower and I didn’t really loose anything but inflammation. With Tirz I’ve upped my calories and have energy to workout so calories out have increased. Overall feeling much better than I have and weight is decreasing.

The drop in inflammation is behind many of the long term benefits, particularly cardiovascular and neurological. GLP has a direct action on blood vessel walls, lowering inflammation and reducing plaque buildup, and preventing neurodegeneration, slowing the steady march to alzheimer's, parkinson's, and general "old brain" problems.

 

[Here2Learn]

The drop in inflammation is behind many of the long term benefits, particularly cardiovascular and neurological. GLP has a direct action on blood vessel walls, lowering inflammation and reducing plaque buildup, and preventing neurodegeneration, slowing the steady march to alzheimer's, parkinson's, and general "old brain" problems.

I’m really hoping as my dose on Tirz goes up I’ll get a bit more inflammation relief. Also, looking at BPC/TB/GHKcu or maybe KPV protocol for some healing.