Sema/Thriz/Reta choices

[Here2Learn]

Currently I’m on Sema, up to 1.25mg/week and have been losing an average of 1lb/week or less. I started at a medspa, just shifted to Skye and now researching China direct. My inflammation can vary widely so the scale jumps all over the place. Sema has helped with inflammation and I’m looking into running BPC/TB for. 6-8 week protocol to see if it helps more and than a series of Thymosin Alpha 1 after that.

My question is with the lower pricing of China direct Tirz/Reta is more affordable so it has become and option. Sema makes me SO tired and I feel like some weeks it works really well and other weeks not as much. If you were to change what would you choose? I’ve researched all of them pretty extensively so I know the pro/cons but looking for people who have switched and what they liked or don’t like.

 

[Ghoul]

Ghoul, you are a wealth of information. I just dropped some serious coin for 1 year of Pharma HGH. Is this a huge risk? Are you saying that eventually your immune system attacks HGH exogenous or endogenous? This sounds like some serious shit.

Ghoul, you are a wealth of information. I just dropped some serious coin for 1 year of Pharma HGH. Is this a huge risk? Are you saying that eventually your immune system attacks HGH exogenous or endogenous? This sounds like some serious shit.

First, I'm not trying to induce unnecessary concern. It's important to understand the potential risks, in context.

Pharma Somatropin, for instance, when used as prescribed, develops anti-drug antibodies, but in extensive trials never rise to the point they effect growth or increase side effects. They don't have a lasting effect after treatment is stopped.

So that's considered acceptable, though it's something they continue to monitor in patients, in case something, like an interaction with another drug might worsen it to the point of "clinical relevance".

The problem is with the far less controlled conditions of black market HGH. Degraded HGH, especially considering much higher doses are used than the pharma trials and legit therapeutic employ, could induce levels of anti-drug antibodies that become a problem. It's not impossible that some forms of "aggregated" HGH not found in pharma could cause a cross immunity to natural GH. No one knows.

So all I'm saying is take the steps you can to keep your HGH(and all peptides) from degrading to the greatest extent possible. The most overlooked is probobly the dilution rate. Over concentration of peptides creates these large Frankenstein aggregates that are the wildcard in terms of how the immune system will react.

 

[Here2Learn]

@Ghoul I don’t know much about steroid side of things and curious about what the difference is between GHRP peptides I see and HGH. I’ve been researching lots of peptides, find the whole subject fascinating, but still have lots to learn.

Mainly I am researching peptides that target inflammation but come across all kinds of them.

 

[Ghoul]

@Ghoul I don’t know much about steroid side of things and curious about what the difference is between GHRP peptides I see and HGH. I’ve been researching lots of peptides, find the whole subject fascinating, but still have lots to learn.

Mainly I am researching peptides that target inflammation but come across all kinds of them.

The conclusion I've come to is that for anti-aging use. a GHRP is the better option over HGH.

By stimulating an increase in the natural production of GH, the natural pulse release, other substances normally secreted with GH, and natural feedback mechanism are kept intact. You're simply "turning up the dial" on GH release to restore the higher levels present when younger.

Like lower "anti-aging" doses of HGH, results take a while, but don't require careful timing and diet adjustments like HGH. Tesamorelin is in and out in under half an hour, but the increased GH release effects persist for over 24 hours. In fact, even after cessation of treatment, levels stay elevated for at least 8 months, so there's evidence it "renews" your ability to produce GH.

Finally, Tesamorelin is FDA approved (Egrifta) and been available for quite a while, so we have a good body of evidence of long term safety.

Tesa was simply too expensive to compete with HGH until recently. You need to commit to six months of daily use for maximum results, so you need 4 x 10mg kits, and really should consider staying on, which is how it's used by patients prescribed it for lipodystrophy.

Semorelin seems promising, using a different mechanism, but an FDA report from last year raising some concerns, along. with a lack of trials and widespread use like Tesa, I've decided to skip for now.