A difference maker? Probably not. But think about it this way.
Situation A - You do not open it. The police bust in ransack the place and find nothing else incriminating. An unopened box. You do not talk.
Situation B - You open it.
Situation C - What usually happens. You open it. You admit to the cops that "yeah, it's steroids," and you admit you opened it because it's yours.
Which situation gives Rick Collins a better chance of getting you acquitted? A, B, or C?
In B, you have no admission, but the prosecutors are going to tell a jury that there is no other damn reason for you to have opened it other than because you were expecting it. Opening it is evidence in and of itself, because it tends to show something.
In A, your attorney can argue that of course you did not open it, because you did not order it and had no idea why this was delivered to your house. Hey, jury, did you notice that she is closely connected to two big steroid monsters? Think one of them could have used her for cover? Doubt. That is all a jury needs to acquit.
In C, well, hope the prosecution offers pretrial diversion or something so your life is not screwed up by a felony conviction. You have left your lawyer no room to do better for you.