Cagrilintide vs. Semaglutide – Which One Would You Choose?

[Nested]

For those who have tried both Cagrilintide and Semaglutide. If you had to pick just one, which would you say is better for fat loss and overall results?

 

[Ghoul]

holy shit thats a lot of sema

That's what I thought but for those who made it to 2.4mg of Sema using the normal titration, going up to 7.2mg didn't increase sides very much. Didn't increase weight loss very much either, increasing from 16% to 21% of body weight.

There are only so many GLP receptors, and once they're saturated, there's no more effect from Sema no matter how large the dose.

The theory explaining different levels of response between individuals is that weight loss is determined by the percentage of total receptors agonized by GLP-1. Those with low receptor density respond more strongly to lower doses. The genetic tests that predict GLP response use receptor density genes as a marker to predict good vs poor responders. People with poor GLP response becaue they have a very high density of receptors are also much more likely to be or become obese.

 

[Luke391]

That's what I thought but for those who made it to 2.4mg of Sema using the normal titration, going up to 7.2mg didn't increase sides very much. Didn't increase weight loss very much either, increasing from 16% to 21% of body weight.

There are only so many GLP receptors, and once they're saturated, there's no more effect from Sema no matter how large the dose.

The theory explaining different levels of response between individuals is that weight loss is determined by the percentage of total receptors agonized by GLP-1. Those with low receptor density respond more strongly to lower doses. The genetic tests that predict GLP response use receptor density genes as a marker to predict good vs poor responders. People with poor GLP response becaue they have a very high density of receptors are also much more likely to be or become obese.

I was thinking the combination of GLP1s and Metformin might be interesting, since Metformin was found to agonize the Leptin receptors in the brain, providing a different pathway for appetite suppression

 

[Ghoul]

I was thinking the combination of GLP1s and Metformin might be interesting, since Metformin was found to agonize the Leptin receptors in the brain, providing a different pathway for appetite suppression

They're often combined by docs for additional weight loss or better glycemic control by doctors. The guidelines from various medical associations recommend it for various scenarios.

I tried metformin but felt like shit on it.

 

[quarter]

Metformin has been a part of the anti-aging ethos for a decade at like 500mg QD

 

[Ghoul]

Metformin has been a part of the anti-aging ethos for a decade at like 500mg QD

I wanted to love it. An ancient drug made from French Lilacs. Extends life. What's not to love?

But the GI sides for me never went away. It was like the first dose of Semaglutide twice a week.

 

[CubanQuentin]

Looks like Sema doses up to 7.2mg are going to hit the market later this year.

Caremark, the 2nd largest pharmacy benefits manager service in the US, covering meds for 103 million patients in the US recently announced they're dropping Zepbound (Tirz) coverage and transitioning those patients to Wegovy (Sema).

That's huge (in a shit way for patients) but a clear indicator Novo Nordisk has decided to offer Sema as the cheaper alternative to Tirz, and going to max doses of 7.2mg for Sema significantly closes the gap between the two.

Still, a lot of metabolic benefits are lost vs Tirz, and a terrible development for future patients with Caremark.

This also brings into question just how willing insurance will be to cover newer, presumably more expensive GLPs like Reta or CagriSema, if they're willing to boot millions of people off Zepbound (which had dropped significantly in price already).

*I say "future" because existing patients with a sharp doctor may be able to fight to keep them on Zepbound, especially if they're on maintenance doses of 12.5mg+ which 7.2mg Sema can't match in terms of weight loss.

Once again Big Pharma strikes. The average "entrepeneur" hustler peddling shit content on social media only wishes they had half the "make money at all costs" drive that those people have lol

 

[Rbvasques]

I did reta with small dose of all the three in different moments.

Reta + cargi and reta + sema, about the same feeling, just not wanting to eat because food gives you nausea or even thinking of food.

Reta + tirz great, forget to eat, and just not feel like eating.

Just Reta, no appetite suppression for me, however, gets full quicker and weight still goes down fast.

I’m in cruise mode now, until blood work gets back to perfect before next blast.
1mg reta 2x week
75mg test 3x week
2iu gh daily