MESO-Rx
Anabolic Steroids
Can touching a barbell in the gym get you sick with the coronavirus?
- Thread starter Michael Scally MD
- Start date
SAN FRANCISCO — For critics of aggressive stay-at-home orders, the solution seems clear: Reopen the economy and enough people will eventually become infected by the novel coronavirus to achieve “herd immunity” even before a vaccine is available.
The idea is that eventually, a sufficient percentage of the population will have survived COVID-19 and become immune, which in turn protects the rest of the uninfected population by interrupting the spread of the virus.
But the disastrous situation unfolding at San Quentin State Prison over the last two months has become the latest of several cautionary tales that show how any effort to achieve herd immunity before a vaccine is available would come with enormous costs in terms of illness and death.
COVID-19 spread unchecked across California’s oldest prison in ways that stunned public health experts, despite efforts to control the disease. As of Monday, there had been more than 2,200 cases and 25 deaths, among a population of more than 3,260 people. On Sunday, a guard became one of the latest to die.
That means more than two-thirds of the prison’s population has been infected, said Dr. George Rutherford, epidemiologist and infectious diseases expert at UC San Francisco.
And though new cases have slowed, they are still occurring — with 60 reported in the last two weeks — suggesting herd immunity has not yet been achieved.
San Quentin’s death toll translates to a mortality rate of about 767 people dying out of every 100,000 persons.
If that same rate occurred across California, that would translate to a staggering 300,000 deaths statewide — many times larger than California’s cumulative death toll of more than 10,400. Nationally, that would be equivalent to 2.5 million deaths; the current cumulative U.S. death toll is more than 163,000.
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[OA] Obesity and Mortality Among Patients Diagnosed With COVID-19
Background: - Obesity, race/ethnicity, and other correlated characteristics have emerged as high-profile risk factors for adverse coronavirus disease 2019 (COVID-19)–associated outcomes, yet studies have not adequately disentangled their effects.
Objective: - To determine the adjusted effect of body mass index (BMI), associated comorbidities, time, neighborhood-level sociodemographic factors, and other factors on risk for death due to COVID-19.
Design: - Retrospective cohort study.
Setting: - Kaiser Permanente Southern California, a large integrated health care organization.
Patients: - Kaiser Permanente Southern California members diagnosed with COVID-19 from 13 February to 2 May 2020.
Measurements: - Multivariable Poisson regression estimated the adjusted effect of BMI and other factors on risk for death at 21 days; models were also stratified by age and sex.
Results: - Among 6916 patients with COVID-19, there was a J-shaped association between BMI and risk for death, even after adjustment for obesity-related comorbidities. Compared with patients with a BMI of 18.5 to 24 kg/m2, those with BMIs of 40 to 44 kg/m2 and greater than 45 kg/m2 had relative risks of 2.68 (95% CI, 1.43 to 5.04) and 4.18 (CI, 2.12 to 8.26), respectively. This risk was most striking among those aged 60 years or younger and men. Increased risk for death associated with Black or Latino race/ethnicity or other sociodemographic characteristics was not detected.
Limitation: - Deaths occurring outside a health care setting and not captured in membership files may have been missed.
Conclusion: - Obesity plays a profound role in risk for death from COVID-19, particularly in male patients and younger populations. Our capitated system with more equalized health care access may explain the absence of effect of racial/ethnic and socioeconomic disparities on death. Our data highlight the leading role of severe obesity over correlated risk factors, providing a target for early intervention.
Tartof SY, Qian L, Hong V, et al. Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization. Annals of internal medicine 2020. https://doi.org/10.7326/M20-3742
Background: - Obesity, race/ethnicity, and other correlated characteristics have emerged as high-profile risk factors for adverse coronavirus disease 2019 (COVID-19)–associated outcomes, yet studies have not adequately disentangled their effects.
Objective: - To determine the adjusted effect of body mass index (BMI), associated comorbidities, time, neighborhood-level sociodemographic factors, and other factors on risk for death due to COVID-19.
Design: - Retrospective cohort study.
Setting: - Kaiser Permanente Southern California, a large integrated health care organization.
Patients: - Kaiser Permanente Southern California members diagnosed with COVID-19 from 13 February to 2 May 2020.
Measurements: - Multivariable Poisson regression estimated the adjusted effect of BMI and other factors on risk for death at 21 days; models were also stratified by age and sex.
Results: - Among 6916 patients with COVID-19, there was a J-shaped association between BMI and risk for death, even after adjustment for obesity-related comorbidities. Compared with patients with a BMI of 18.5 to 24 kg/m2, those with BMIs of 40 to 44 kg/m2 and greater than 45 kg/m2 had relative risks of 2.68 (95% CI, 1.43 to 5.04) and 4.18 (CI, 2.12 to 8.26), respectively. This risk was most striking among those aged 60 years or younger and men. Increased risk for death associated with Black or Latino race/ethnicity or other sociodemographic characteristics was not detected.
Limitation: - Deaths occurring outside a health care setting and not captured in membership files may have been missed.
Conclusion: - Obesity plays a profound role in risk for death from COVID-19, particularly in male patients and younger populations. Our capitated system with more equalized health care access may explain the absence of effect of racial/ethnic and socioeconomic disparities on death. Our data highlight the leading role of severe obesity over correlated risk factors, providing a target for early intervention.
Tartof SY, Qian L, Hong V, et al. Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization. Annals of internal medicine 2020. https://doi.org/10.7326/M20-3742
[OA] COVID-19 and Severe Obesity: A Big Problem?
On 11 March 2020, the World Health Organization declared coronavirus disease 2019 (COVID-19) a pandemic. The disease, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has now infected nearly 20 million persons worldwide, with a global mortality rate of 3.7%.
It is unusual in that symptoms range from none to severe respiratory failure with diffuse lung damage and death. Given these diverse effects, understanding the risks for developing the most severe manifestations was particularly important from the start. Early reports from China and Italy, where the pandemic first took hold, identified a broad range of factors—old age, autoimmune disease, hypertension, and coronary artery disease—as risks for worse outcomes.
However, as the pandemic reached the United States, another factor appeared that was particularly common in severely affected patients: obesity. The United States has a 20% rate of severe obesity (body mass index [BMI] >35 kg/m2) and a 10% rate of morbid obesity (BMI >40 kg/m2)—the highest rates in the industrialized world. More than 40% of Americans are considered obese (BMI >30 kg/m2).
One possibility was that given this high prevalence, one would expect to find obesity more often in patients with COVID-19 as well. Yet, by early April, research was countering this hypothesis, showing that patients with COVID-19 in the intensive care unit were more likely to be obese than historical ICU patients without COVID-19 (1), and that obese persons who had COVID-19 were more likely to require hospitalization and intensive care unit treatment (2).
In contrast to other known risk factors, obesity was very common even in persons younger than 50 years, and this high prevalence predicted a shift in severe COVID-19 disease to younger populations (3).
…
Kass DA. COVID-19 and Severe Obesity: A Big Problem? Annals of internal medicine 2020. https://doi.org/10.7326/M20-5677
Florida sheriff bans his deputies and office visitors from wearing masks on a day his county broke records for Covid-19 deaths - CNN
Political horseshit. Note all then people sick in that jail, including law enforcement. Note the incredible rise in cases and deaths in that county.
Political horseshit. Note all then people sick in that jail, including law enforcement. Note the incredible rise in cases and deaths in that county.
Joe Morgan
Member
“Biden calls for mandate requiring all Americans to wear masks”
Former Vice President Joe Biden on Thursday called for a nationwide mask mandate to help fight the spread of the coronavirus pandemic.
“Every American should be wearing a mask when they’re outside for the next three months at a minimum,” Biden told reporters in Wilmington, Del.”
Biden calls for mandate requiring all Americans to wear masks
“Joe Biden says he would sign order forcing Americans to wear masks”
In an interview with CBS Pittsburgh affiliate KDKA, the former veep said he would sign an executive order and use all the tools in his arsenal to force people to wear face coverings in public amid the coronavirus pandemic.”
https://www.google.com/amp/s/nypost...gn-order-forcing-americans-to-wear-masks/amp/
lmao
Former Vice President Joe Biden on Thursday called for a nationwide mask mandate to help fight the spread of the coronavirus pandemic.
“Every American should be wearing a mask when they’re outside for the next three months at a minimum,” Biden told reporters in Wilmington, Del.”
Biden calls for mandate requiring all Americans to wear masks
“Joe Biden says he would sign order forcing Americans to wear masks”
In an interview with CBS Pittsburgh affiliate KDKA, the former veep said he would sign an executive order and use all the tools in his arsenal to force people to wear face coverings in public amid the coronavirus pandemic.”
https://www.google.com/amp/s/nypost...gn-order-forcing-americans-to-wear-masks/amp/
lmao
[OA] Italian Males Recovering from Mild COVID-19 Show No Evidence of SARS-Cov-2 in Semen Despite Prolonged Nasopharyngeal Swab Positivity
At the time of this article, few studies looking for the presence of SARS-CoV-2 in human semen are available but have come to discordant conclusions. In particular, while the detection of SARS-CoV-2 RNA in semen during the acute phase of severe symptomatic infections has already been demonstrated, weaker evidence has been shown of virus shedding through semen in the recovery phase or convalescence of COVID-19 and in patients with mild symptoms or in asymptomatic cases. Therefore, we tried to determine if SARS-CoV-2 is detectable in the semen of Italian patients showing mild or no symptoms of COVID-19 at the time of sampling, in order to better understand if sexual transmission is to be considered for the spread of SARS-CoV-2. …
Pavone, C., Giammanco, G.M., Baiamonte, D. et al. Italian males recovering from mild COVID-19 show no evidence of SARS-CoV-2 in semen despite prolonged nasopharyngeal swab positivity. Int J Impot Res (2020). https://doi.org/10.1038/s41443-020-00344-0
At the time of this article, few studies looking for the presence of SARS-CoV-2 in human semen are available but have come to discordant conclusions. In particular, while the detection of SARS-CoV-2 RNA in semen during the acute phase of severe symptomatic infections has already been demonstrated, weaker evidence has been shown of virus shedding through semen in the recovery phase or convalescence of COVID-19 and in patients with mild symptoms or in asymptomatic cases. Therefore, we tried to determine if SARS-CoV-2 is detectable in the semen of Italian patients showing mild or no symptoms of COVID-19 at the time of sampling, in order to better understand if sexual transmission is to be considered for the spread of SARS-CoV-2. …
Pavone, C., Giammanco, G.M., Baiamonte, D. et al. Italian males recovering from mild COVID-19 show no evidence of SARS-CoV-2 in semen despite prolonged nasopharyngeal swab positivity. Int J Impot Res (2020). https://doi.org/10.1038/s41443-020-00344-0
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