Capping and Preserving Accutane Raws

[BroScientist]

Fourth dose. I didn't realize that my slightly pink cast was due to acne. Upon waking, my face is super white, almost has a green cast since you can see the blood under my skin. I'm going to have to get a light tan after this is over. From the studies, for those with mild to moderate acne, the course can be until the acne completely clears plus one month. I think that's the plan from here out. I may attempt to bump the dose up to 40mg/day just to get this over with faster.

Sucks though, I was going to blast, but I don't know that I really want to blast while on 20mg/40mg accutane a day.

 

[BroScientist]

Trial 2:
I changed my solvent to olive oil. I figured that since I'm freezing my capsules, they don't need to be solid at room temperature, just in the freezer.

I heated 24ml olive oil to 100C, added 280mg accutane, and put it on my freshly built magnetic stirrer for 20 minutes. While my computer fan stirrer is under powered by lab standards, it achieved a nice vortex with minimal splashing. I used a glass pipette for metering the dose. Reading the graduations under faint red light was an issue, I metered the first out, and then did the rest by eye. Overall the process went smoother. More product was dissolved/suspended in the oil and there was not much product in my beaker after dispensing.

After freezing, there was some fall out in the capsules, but not as much as last time, and I had doubled the oil+accutane in each capsule from last time.

I think I'm close to achieving a workable process. I think the two things that can be improved are using a better solvent that doesn't dissolve the gelatin caps and adding heat during the stirring process. I could also stir for longer, but I don't think that's going to do much.

@janoshik as our resident chemist, any suggestions on a solvent or a better oil?

 

[janoshik]

Trial 2:
I changed my solvent to olive oil. I figured that since I'm freezing my capsules, they don't need to be solid at room temperature, just in the freezer.

I heated 24ml olive oil to 100C, added 280mg accutane, and put it on my freshly built magnetic stirrer for 20 minutes. While my computer fan stirrer is under powered by lab standards, it achieved a nice vortex with minimal splashing. I used a glass pipette for metering the dose. Reading the graduations under faint red light was an issue, I metered the first out, and then did the rest by eye. Overall the process went smoother. More product was dissolved/suspended in the oil and there was not much product in my beaker after dispensing.

After freezing, there was some fall out in the capsules, but not as much as last time, and I had doubled the oil+accutane in each capsule from last time.

I think I'm close to achieving a workable process. I think the two things that can be improved are using a better solvent that doesn't dissolve the gelatin caps and adding heat during the stirring process. I could also stir for longer, but I don't think that's going to do much.

@janoshik as our resident chemist, any suggestions on a solvent or a better oil?

Hmm... Check out DMSO, see whether it dissolves your caps? Imo DMSO is underrepresented as a solvent for human use dmso also effectively blocks UV in this case

 

[BroScientist]

Hmm... Check out DMSO, see whether it dissolves your caps? Imo DMSO is underrepresented as a solvent for human use dmso also effectively blocks UV in this case

Yes, I considered DMSO. It's not available in capsules anywhere, which probably means it will dissolve them. However, it has a very high freezing point, if I cap and stick them in the freezer quick, it could work. I don't know what that will do to the solution, maybe it forces the accutane out of solution, maybe not. I haven't a clue. If I go the DMSO route, I may also need to vastly lower the dose, IIRC bioavailability of oral accutane is under 20% normally. I suspect DMSO would vastly increase the absorption rate and may additionally cause it to absorb places in the body it normally wouldn't.

 

[BroScientist]

I'm also considering benzyl benzoate. I'll have to run some tests on the gelatin capsules again.

 

[janoshik]

Yes, I considered DMSO. It's not available in capsules anywhere, which probably means it will dissolve them. However, it has a very high freezing point, if I cap and stick them in the freezer quick, it could work. I don't know what that will do to the solution, maybe it forces the accutane out of solution, maybe not. I haven't a clue. If I go the DMSO route, I may also need to vastly lower the dose, IIRC bioavailability of oral accutane is under 20% normally. I suspect DMSO would vastly increase the absorption rate and may additionally cause it to absorb places in the body it normally wouldn't.

Experiment time!

 

[BroScientist]

Experiment time!

Lol, thanks for volunteering me. The part of it that really concerns me is the "may vastly increase the absorption rate and may additionally cause it to absorb places in the body it normally wouldn't."
I think I'll try the BB first, but I'm not confident the accutane won't fall out considering that various T esters fall out when a bottle is cooled. It could also depend on the ratio used.

 

[janoshik]

Lol, thanks for volunteering me. The part of it that really concerns me is the "may vastly increase the absorption rate and may additionally cause it to absorb places in the body it normally wouldn't."
I think I'll try the BB first, but I'm not confident the accutane won't fall out considering that various T esters fall out when a bottle is cooled. It could also depend on the ratio used.

You can always start at like 5 mg / cap to be safe. Or we can do a gofundme for a nice tombstone for ya. Whichever suits ya

 

[Bulldog413]

Jano, would these raws be safe from degradation in a suspension?

 

[janoshik]

Jano, would these raws be safe from degradation in a suspension?

If the liquid of the suspension absorbs UV and doesn't have oxidative properties, than yeah, it would.

What kind of suspension you have in mind? Maybe I can provide you with better info.

 

[Bulldog413]

Well, I made a bottle suspended in HUMCO vehicle 3 weeks ago, at 20mgs a day, its doing well for clearing me up even have started a blast. I have the remaining raws in a ziplock bag rolled up and stored in a safe lock box that is fireproof. I keep the suspended Accutane in a dresser drawer away from light also, its never exposed for more than a few secs.

 

[Bulldog413]

Hopefully my raws will be safe where they are located, id hate to have to premix 19 more bottles. I used 1g Accutane and 49ml HUMCO dosed at 20mg/ml

 

[janoshik]

HUMCO fixed oil suspension?

 

[Bulldog413]

HUMCO Flavor Plus Compounding Vehicle

 

[janoshik]

HUMCO Flavor Plus Compounding Vehicle

As far as I can tell it is permeable to UV.

 

[Bulldog413]

Ok thanks, but would it remain ok in a dresser drawer and not going outside in direct sunlight? Only taking it out for a couple secs to draw and swallow. Raws are secured in a lockbox safe.

 

[janoshik]

Ok thanks, but would it remain ok in a dresser drawer and not going outside in direct sunlight? Only taking it out for a couple secs to draw and swallow. Raws are secured in a lockbox safe.

It certainly helps

I wouldn't be overly worried, but I would definitely get liver(+general) bloods done once a month or two.

 

[Bulldog413]

Yes sir, your input is much appreciated Jano. thx man

 

[janoshik]

Yes sir, your input is much appreciated Jano. thx man

happy to help!

 

[BroScientist]

I wouldn't be overly worried, but I would definitely get liver(+general) bloods done once a month or two.

Definitely good advice. Accutane is really hard on the liver. There are some studies that say ever 2 months is ok for bloodwork, but traditionally, it's every month. Personally, I think the highest dose I plan on running is 0.5mg/kg instead of the more traditional 1mg/kg dose, so hopefully that will mitigate some of the damage.

I'm also really clearing up fast on 40mg/day, so maybe I'm only looking at 1-2 months total run time.

In other news, I'm considering lowering the concentration of accutane in my capsules, I might be able to get 15mg into solution in 1ml vs having some small precipitation at 20mg/1ml. I guess I could go as low as 10mg/ml and do 4 caps per day, but that's a lot of capping. I'll have to decide over the next week or so.