This is why my Dr. lowered my HCG because my last test on E2 doing one pill of Indolplex/DIM and taking .5 Arimidex every other day my E2 was high 49 range <20 to 56 pg/mL and my DHT was 2205 range 36 to 573 pg/mL. I am not at a low level of E2 I can tell the difference. First thing that goes is my morning wood and I can't get it up for sex taking a pill. I don't have this problem. But I am having panic problems in the middle of the night if I take an Arimidex .5 mgs pill the panic goes away. The next thing will be to lower the T shots. It can be like you said 250 IU's is still good enough to keep my levels high and I think they are still to high. I lowered the HCG over 2 weeks a go I don't feel like I am crashing at all. I get my next test next Tue. then we will know. But in the mean time my to keep my E2 in the zone I am having to take more Arimidex. My Dr. is on top of this I am not taking anything that he has not told me to do. But man the weight loss has stopped and I am kicking ass in the gym on upping my load that I work out with so I am getting stronger fast.