Dnp gave me cataracts at the age of 22

[redbeard99]

listen, im not being a bitch or scaremonger but i feel i need to tell my story. i am not blaming anyone but myself. i have used dnp over and over many times. it is the best fat burner in the world, it works MIRACLES. i never once thought i would have long term issues. i pushed doses sometimes over 1000 mg a day, sometimes 6 caps a day. i stopped my last cycle about a month ago and about a week after stopping i noticed lights were a little brighter than usual and things in the distance were appearing blurry. i knew something was wrong with my eyes (i have always had 100% perfect vision) but did not even THINK that dnp could be the culprit. i went to eye doctor and after doing tests for a while she told me i had cataracts in both eyes, my left worse than the right. i am only 22 for the record with no family history of cataracts or eye issues. IMMEDIATELY i remembered reading that cataracts was a possible issue if using dnp. i was terrified, absolutely mortified, i still am scared considering i just found all this out last week. i have surgery next month and all should be okay after that. if u want to use DNP just know, yes it works 100% unreal, the best there is for burning fat, but sometimes, especially in this case, if u want unbelievable results, they are not free.

 

[Mike Oxbig]

The funny thing is, all these 'awful concerns' you have over the saftey of DNP also apply to steroid use. You guys are really reacting like the general public does to AAS. "You can never know what you are getting off the black market" A little hypocritical don't you think?

If AAS had a therapeutic window as small as DNP I would feel the same way about anabolics.

Trying to draw a similarity between infection risk and death is a bit of an apples to oranges comparison.

When I was researching DNP I genuinely wanted to conclude that the hysteria was overblown and that it could be a safe compound to use, but that really isn't the case. It's just not worth the risk.

 

[CensoredBoardsSuck]

The funny thing is, all these 'awful concerns' you have over the saftey of DNP also apply to steroid use. You guys are really reacting like the general public does to AAS. "You can never know what you are getting off the black market" A little hypocritical don't you think? Plus you don't just get a random supplier and take 1G of DNP. People that do that are asking for a dirt nap. I agree that DNP is extremely dangerous if you are stupid about using it. There is some risk to everything in life but that risk is very minimal if you use DNP intelligently (no more risk than using AAS imo). Using DNP intelligently also encompasses being smart about suppliers.

It's not a question of being "stupid about using it." Its effects are unpredictable. Your suggestion that AAS have a similar risk is nonsense.

The following case report on a dnp fatality shows how quickly things can go wrong. In this case, the patient went from lucid and cooperative to agitated and delirious in the ER in a short time. Despite intensive medical intervention, he still died.

Vet Hum Toxicol. 2004 Oct;46(5):251-4.
Dying to be thin: a dinitrophenol related fatality. Dying to be thin: a dinitrophenol related fa... [Vet Hum Toxicol. 2004] - PubMed - NCBI
McFee RB, Caraccio TR, McGuigan MA, Reynolds SA, Bellanger P.

Abstract

2, 4-dinitrophenol (DNP) was originally used as an explosive and later introduced in the 1930's to stimulate metabolism and promote weight loss. It's also a component of pesticides still available globally. Concerns about hyperpyrexia lead to DNP being banned as a dietary aid in 1938. A 22-y-old male presented to the Emergency Department (ED) with a change in mental status 16 h after his last dose of DNP. On admission he was diaphoretic and febrile with an oral temperature of 102 F, but lucid and cooperative. He became agitated and delirious. Intravenous midazolam was initiated with mechanical cooling. Pancuronium was administered later and the patient was intubated. Over the next hour the patient became bradycardic, then asystolic, and despite resuscitative efforts, died. Advertisements claim DNP safe at the dose our patient ingested. It is widely available and with the potential to cause severe toxicity is an understudied public health concern.

and with regard to DNP and cataracts, this is why Vit C,E and NAC supplementation is highly advised

This statement is so ridiculous, it doesn't even deserve a response. Utter absurdity.

CBS

 

[fatfatfatfat]

It's not a question of being "stupid about using it." Its effects are unpredictable. Your suggestion that AAS have a similar risk is nonsense.

The following case report on a dnp fatality shows how quickly things can go wrong. In this case, the patient went from lucid and cooperative to agitated and delirious in the ER in a short time. Despite intensive medical intervention, he still died.

Vet Hum Toxicol. 2004 Oct;46(5):251-4.
Dying to be thin: a dinitrophenol related fatality. Dying to be thin: a dinitrophenol related fa... [Vet Hum Toxicol. 2004] - PubMed - NCBI
McFee RB, Caraccio TR, McGuigan MA, Reynolds SA, Bellanger P.

Abstract

2, 4-dinitrophenol (DNP) was originally used as an explosive and later introduced in the 1930's to stimulate metabolism and promote weight loss. It's also a component of pesticides still available globally. Concerns about hyperpyrexia lead to DNP being banned as a dietary aid in 1938. A 22-y-old male presented to the Emergency Department (ED) with a change in mental status 16 h after his last dose of DNP. On admission he was diaphoretic and febrile with an oral temperature of 102 F, but lucid and cooperative. He became agitated and delirious. Intravenous midazolam was initiated with mechanical cooling. Pancuronium was administered later and the patient was intubated. Over the next hour the patient became bradycardic, then asystolic, and despite resuscitative efforts, died. Advertisements claim DNP safe at the dose our patient ingested. It is widely available and with the potential to cause severe toxicity is an understudied public health concern.


CBS

Useless information. There is nothing at all about the dose he ingested, how long he was on it, what other stuff he was doing/not doing.

steroid related death

http://news.sky.com/story/1101193/steroids-put-teenage-bodybuilders-at-risk

How is the story you posted and the ones above any different?

And show me someone who has developed cataracts with a sane DNP dose (not over 1000mg like OP) while using proper supplementation.

 

[loveyourbody]

Fatfatfat- ok I agree with you on that. I thinking my height had some effect on the sides I had. Never made it to 5'9 like my little bro. But, I'm just going to stay away. If DNP taught me something was that there are no short cuts in life. I made myself get down to 8% body fat with diet and training alone. If you can handle DNP I say go for it. I myself would only recommend it to someone I hate with a passion and want them to slowly suffer

 

[fatfatfatfat]

Fatfatfat- ok I agree with you on that. I thinking my height had some effect on the sides I had. Never made it to 5'9 like my little bro. But, I'm just going to stay away. If DNP taught me something was that there are no short cuts in life. I made myself get down to 8% body fat with diet and training alone. If you can handle DNP I say go for it. I myself would only recommend it to someone I hate with a passion and want them to slowly suffer

100% agree you absolutely do not need DNP for any fitness goal but it can be used effectively in the right circumstances. I'm 5' 7" and I stick at 250mg personally. Even if I was 200lbs my organs are smaller and I have less surface area compared to someone 6'.

 

[Dr JIM]

There is no comparison between the sides of DNP and AAS unless you believe cyanide and DNP have similar therapeutic windows!

Here you go with this stupid supplement garbage again. What evidence do you have that this shit makes any difference at all, ZIPPO.

Fine so let's compare the ANABOLIC effects of AAS and the CATABOLIC effects of DNP, lol!

This crap is absolutely the worst shit a BB or lifter could use IF they want to improve either MUSCLE MASS, STRENGTH, POWER or LBM, GLYCOGEN STORES etc! (So for those whom believe it's useful for cutting fat NOT!!!)

Is it at all selective for what it uses as an energy source for the entropy generated, NOPE!!! Shit Jim what are you saying? This junk uses all sources of available energy from fat, carbs to that protein you spent 12 weeks accumulating during your last cycle, what a damn counterintuitive JOKE!

What the F is it good for lardass? Why are you pushing this pis? Are you interested in helping or hurting other lifters?

So fatso tell us on MESO about how DNP is a PERFORMANCE ENHANCING DRUG, LMAO!

 

[CensoredBoardsSuck]

Useless information. There is nothing at all about the dose he ingested, how long he was on it, what other stuff he was doing/not doing.

steroid related death

http://news.sky.com/story/1101193/steroids-put-teenage-bodybuilders-at-risk

How is the story you posted and the ones above any different?

And show me someone who has developed cataracts with a sane DNP dose (not over 1000mg like OP) while using proper supplementation.

Proper supplementation? LMFAO!! THAT is what's known as useless information. I'd like to see your evidence for that gem - and from the scientific literature, not bro science from some bodybuilding forum.

What dose do you think patients were using in the 1930's when the cataracts thing became known? Megadoses? Give me a break.

FYI, the lowest published lethal human oral dose of DNP is 4.3 mg/kg. That's 430 mg for a 100kg person. 2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death

The reason for the low number of reported deaths since the late 1930s is because so few people have used it. That started changing a decade ago with a resurgence in the popularity of using dnp for weightloss due to its easy availability on the internet. From 2001 to 2010, there have been 12 deaths related to exposure to DNP. Expect that number to rise.

CBS

 

[Candyskull]

Do you know how many people die from aspirin every year Jim?

I absolutely hate how often I see people say this in regards to DNP. The ratio of people dying is what's important here, not the actual number of people. Millions and millions of people worldwide use aspirin on a daily basis. Not so much DNP.

Also, the effective dose to LD50 dose ratio is over 100 times greater for aspirin. As in, it's pretty hard to fuck up and kill yourself with aspirin, whereas it's remarkably easy to kill yourself with DNP in comparison.

I agree that DNP can be used without dying, but you have to admit its not just stupid people (who, by the way, there are shit loads of) that die from DNP. The compound itself is inherently risky, period. I can take half a bottle of aspirin, or shoot myself full of 5 grams of testosterone, and survive no problem. It's scary to think that 4 DNP might kill me since the effective dose at my weight and height is 2.

 

[fatfatfatfat]

The reason for the low number of reported deaths since the late 1930s is because so few people have used it. That started changing a decade ago with a resurgence in the popularity of using dnp for weightloss due to its easy availability on the internet. From 2001 to 2010, there have been 12 deaths related to exposure to DNP. Expect that number to rise.

CBS

Upwards of 500,000 people took DNP in the 30s and there were 8 deaths iirc.

I agree that DNP can be used without dying, but you have to admit its not just stupid people (who, by the way, there are shit loads of) that die from DNP. The compound itself is inherently risky, period. I can take half a bottle of aspirin, or shoot myself full of 5 grams of testosterone, and survive no problem. It's scary to think that 4 DNP might kill me since the effective dose at my weight and height is 2.

Fair enough. Still when have you accidentally overdosed anything you were taking regularly? I haven't not once in my life that I can remember. Not even my multi. There's no reason to think that when taking something as serious as DNP that you will let your guard down all of the sudden and accidentally take too much. Maybe thats just me. It's obviously more risk..but the reward can be worth it, that's ultimately a personal decision.

Here you go with this stupid supplement garbage again. What evidence do you have that this shit makes any difference at all, ZIPPO.

Jim, if you read the NAC link I posted you'll see several studies cited in the wikipedia page regarding the effectiveness of NAC with cataracts. Do I have evidence it prevents any DNP related cataracts? No. But the supposed cause of cataracts from DNP use is the increased free radicals which NAC, Vit C, E supposedly help. So there is reason to believe they may be effective...in the end they are just precautionary measures...I have yet to see any report of cataracts in males under sane dosage protocols. Moreover, the occurence of cataracts was extremely extremely small during widespread use of DNP as a dieting drug in the 30s.

Fine so let's compare the ANABOLIC effects of AAS and the CATABOLIC effects of DNP, lol!

This crap is absolutely the worst shit a BB or lifter could use IF they want to improve either MUSCLE MASS, STRENGTH, POWER or LBM, GLYCOGEN STORES etc! (So for those whom believe it's useful for cutting fat NOT!!!)

Is it at all selective for what it uses as an energy source for the entropy generated, NOPE!!! Shit Jim what are you saying? This junk uses all sources of available energy from fat, carbs to that protein you spent 12 weeks accumulating during your last cycle, what a damn counterintuitive JOKE!

What the F is it good for lardass? Why are you pushing this pis? Are you interested in helping or hurting other lifters?

So fatso tell us on MESO about how DNP is a PERFORMANCE ENHANCING DRUG, LMAO!

Jim I am not a lardass In the end we are all pursuing the best information regarding bodycomposition and quality of life and DNP can have it's place in one's life. It's not for everybody but so arent a lot of things.
DNP from my experience and that of others is very muscle sparing for the fat burning it delivers. It is hands down the most effective fat burner available but if you dont take my word for it there are thousands of others that will tell you the same thing (plus would we be having this conversation if DNP wasnt super effective? if it wasn't nobody would bother with the risks). It can also be used along AAS. Obviously it's not anabolic, but DNP has stayed popular in the undergrounds for a reason.

I want to add something else that doesn't really apply to anyone on these boards. DNP can be a life saving miracle in clinically obese patients. How many people die every year from complications related to being overweight/obese? A hell of a lot....just something to think about....that's really why I am so "pro-DNP"

I think we've exhausted the topic for now.

-regards

 

[fit2beking]

I absolutely hate how often I see people say this in regards to DNP. The ratio of people dying is what's important here, not the actual number of people. Millions and millions of people worldwide use aspirin on a daily basis. Not so much DNP.

Also, the effective dose to LD50 dose ratio is over 100 times greater for aspirin. As in, it's pretty hard to fuck up and kill yourself with aspirin, whereas it's remarkably easy to kill yourself with DNP in comparison.

I agree that DNP can be used without dying, but you have to admit its not just stupid people (who, by the way, there are shit loads of) that die from DNP. The compound itself is inherently risky, period. I can take half a bottle of aspirin, or shoot myself full of 5 grams of testosterone, and survive no problem. It's scary to think that 4 DNP might kill me since the effective dose at my weight and height is 2.

:goodpost:

 

[Dr JIM]

Aspirin deaths related to an intentional OD have noting to do with unintentional deaths from DNP because NO DNP DOSE has been proven safe compared to the very broad therapeutic of ASA. .

Moreover aspirin UNEQUIVOCALLY has several proven medicinal benefits much like the antibiotic PCN, but because a some have perished from PCN mediated allergic reactions I suppose we should be rid the world of that therapeutic menace also, LMAO.

Your a foolish clown and are only worsening your position on this forum with the strawman arguments.

Yea I've answered your grab-bag questions how about you answer ANY of mine, several which are based on my direct exposure to the BUNK in the ED.

It never ceases to amaze me what obese folk are willing to do to loose weight, excepting that which is proven effective long term, diet and exercise!

What a shame people like fatyfaty give these folks another pipe dream for their next dietary failure.

Jim