INDEED
MESO-Rx
Anabolic Steroids
First cycle please help
- Thread starter Goodlivin32
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INDEED
I thought this was applicable for those whom are legitimately interested in developing a better understanding of AAS associated "fat loss", exclusive of bro science.
Incidentally, it's prophetic how a study conducted in 1999 is only available in "abstract form" some 17 YEARS later! And to think such "research" was cited by someone who chose my man ARNIE S as his Avatar, LOL
Incidentally, it's prophetic how a study conducted in 1999 is only available in "abstract form" some 17 YEARS later! And to think such "research" was cited by someone who chose my man ARNIE S as his Avatar, LOL
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Michael Scally MD
Can you locate this "study" as I had no luck. It seems "Art" is fond of the old cut, paste and reload from one forum to another (inserting the opinions of others during the transition) form of "evidence based" methodology.
Thx
I thought Scally was the all-knowing being at Meso?! Are you hinting that his powers are limited
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J Clin Endocrinol Metab. 2003 Mar;88(3):1167-73.
The male contraceptive regimen of testosterone and levonorgestrel significantly increases lean mass in healthy young men in 4 weeks, but attenuates a decrease in fat mass induced by testosterone alone.
Herbst KL1, Anawalt BD, Amory JK, Matsumoto AM, Bremner WJ.
Author information
Abstract
In hypogonadal men, testosterone (T) in replacement dosages is known to increase fat-free mass (lean mass) and decrease fat mass. In young eugonadal men, similar dosages of T increase lean mass, but much higher dosages of T are required to decrease total body fat mass. Current T-based male hormonal contraceptive regimens include a second agent, such as a progestin, to maximize inhibition of pituitary gonadotropins and improve efficacy. To study the effect of such combinations on body composition, we randomized healthy, young, eugonadal men into four combinations of exogenous T and the progestin, levonorgestrel (LNG): 1) 100 mg T enanthate, im, weekly plus 125 micro g LNG, orally, daily (T+LNG); 2) T plus placebo LNG (T alone); 3) placebo T plus LNG (LNG alone); and 4) placebo T plus placebo LNG (placebo). We then analyzed body composition by dual energy x-ray absorptiometry after 4 and 8 wk of treatment. T+LNG significantly increased total lean mass after 4 and 8 wk of treatment (3.5 +/- 0.9% and 4.2 +/- 1.2%, respectively; P < 0.05) and truncal lean mass after 4 and 8 wk of treatment (4.7 +/- 0.9% and 5.0 +/- 0.9%, respectively; P < 0.05) compared with baseline and placebo. T alone also increased total and truncal lean mass significantly compared with placebo after 4 wk of treatment, but not compared with baseline (3.3 +/- 1.4% and 3.2 +/- 2.3%, respectively; P < 0.05 vs. placebo), suggesting an additive effect of T and LNG to increase lean mass. Fat mass significantly decreased in the abdomen in men administered T alone compared with LNG alone (-4.9 +/- 2.8%; P < 0.05). Fat mass significantly increased in the abdomen with LNG alone (4.1 +/- 1.0%; P < 0.05) compared with baseline and was unchanged with the combination of T+LNG, suggesting that LNG attenuates the decrease in fat mass seen with T alone. There was no change in weight or body mass index in any group during the study. This study shows that in young eugonadal men 1) T alone rapidly increases lean mass and decreases fat mass in 4-8 wk; 2) T+LNG rapidly increases lean mass, but has no effect on fat mass; and 3) LNG alone increases fat mass. The favorable profile on body composition by T is, therefore, partially attenuated by the progestin, LNG. These findings suggest that androgen-based male hormonal contraceptives might have favorable effects on body composition. The impact of these changes on cardiovascular risk in normal men needs further study."
mands
J Clin Endocrinol Metab. 2003 Mar;88(3):1167-73.
The male contraceptive regimen of testosterone and levonorgestrel significantly increases lean mass in healthy young men in 4 weeks, but attenuates a decrease in fat mass induced by testosterone alone.
Herbst KL1, Anawalt BD, Amory JK, Matsumoto AM, Bremner WJ.
Author information
Abstract
In hypogonadal men, testosterone (T) in replacement dosages is known to increase fat-free mass (lean mass) and decrease fat mass. In young eugonadal men, similar dosages of T increase lean mass, but much higher dosages of T are required to decrease total body fat mass. Current T-based male hormonal contraceptive regimens include a second agent, such as a progestin, to maximize inhibition of pituitary gonadotropins and improve efficacy. To study the effect of such combinations on body composition, we randomized healthy, young, eugonadal men into four combinations of exogenous T and the progestin, levonorgestrel (LNG): 1) 100 mg T enanthate, im, weekly plus 125 micro g LNG, orally, daily (T+LNG); 2) T plus placebo LNG (T alone); 3) placebo T plus LNG (LNG alone); and 4) placebo T plus placebo LNG (placebo). We then analyzed body composition by dual energy x-ray absorptiometry after 4 and 8 wk of treatment. T+LNG significantly increased total lean mass after 4 and 8 wk of treatment (3.5 +/- 0.9% and 4.2 +/- 1.2%, respectively; P < 0.05) and truncal lean mass after 4 and 8 wk of treatment (4.7 +/- 0.9% and 5.0 +/- 0.9%, respectively; P < 0.05) compared with baseline and placebo. T alone also increased total and truncal lean mass significantly compared with placebo after 4 wk of treatment, but not compared with baseline (3.3 +/- 1.4% and 3.2 +/- 2.3%, respectively; P < 0.05 vs. placebo), suggesting an additive effect of T and LNG to increase lean mass. Fat mass significantly decreased in the abdomen in men administered T alone compared with LNG alone (-4.9 +/- 2.8%; P < 0.05). Fat mass significantly increased in the abdomen with LNG alone (4.1 +/- 1.0%; P < 0.05) compared with baseline and was unchanged with the combination of T+LNG, suggesting that LNG attenuates the decrease in fat mass seen with T alone. There was no change in weight or body mass index in any group during the study. This study shows that in young eugonadal men 1) T alone rapidly increases lean mass and decreases fat mass in 4-8 wk; 2) T+LNG rapidly increases lean mass, but has no effect on fat mass; and 3) LNG alone increases fat mass. The favorable profile on body composition by T is, therefore, partially attenuated by the progestin, LNG. These findings suggest that androgen-based male hormonal contraceptives might have favorable effects on body composition. The impact of these changes on cardiovascular risk in normal men needs further study."
mands
GTG
Those are less than impressive P values for such a small study, especially considering whenever LBM increases TFM will decrease on proportional basis
Finally the authors fail to mention or even propose a MOA for the fat reduction changes observed.
I'll review the entire study THX
MANDS
Take a look at the citation I posted earlier with a much better controlled study design and a proposed MOA being changes in Leptin and Adiopnectin, both proven FALSE.
Heck even if a substance mobilizes adipose triglycerides into FFA, in order for fat reduction to occur metabolic processes must be properly aligned to ensure available Fatty Acids are catabolized or they will simply reassemble into their prior fat like state.
Scientists have played with ways to selectively cut the fat via the induction/reduction of certain metabolic pathways and we are STILL LOOKING some 50 years later.
Heck even if a substance mobilizes adipose triglycerides into FFA, in order for fat reduction to occur metabolic processes must be properly aligned to ensure available Fatty Acids are catabolized or they will simply reassemble into their prior fat like state.
Scientists have played with ways to selectively cut the fat via the induction/reduction of certain metabolic pathways and we are STILL LOOKING some 50 years later.
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