For the fellow chemists - is there non 17α-alkylated Oxandrolone?

[Elistheman]

What benefits would present themselves from the removal of this chain?

Removal of the methyl would first of all reduce if not remove the hepatotoxicity. second, it will change the pharmacokinetics but this is where speculation starts.

 

[MisterSuperGod]

I know, again not my question... I was asking about a non 17α-alkylated derivative

There aren't any, to my knowledge and unless an underground chemist can produce it, there will never be any.

The best chances of that happening would have been in the prohormone era. Too late for that now.

The original orals have been around a long time. They're relatively safe and effective for what they're prescribed for.

No pharmaceutical company is going to invest a billion dollars into a 50 year old drug that's already safe when used as prescribed.

 

[T L]

Removal of the methyl would first of all reduce if not remove the hepatotoxicity. second, it will change the pharmacokinetics but this is where speculation starts.

I guess what I am saying is: who knows how the compounds would act after removal of the methyl. Possibly beneficial. Possibly not. Maybe loss of potency or androgenic activity.

 

[T L]

I guess what I am saying is: who knows how the compounds would act after removal of the methyl. Possibly beneficial. Possibly not. Maybe loss of potency or androgenic activity.

All speculation after this point—as you said.

 

[Pineapples4Puss]

Removal of the methyl would first of all reduce if not remove the hepatotoxicity. second, it will change the pharmacokinetics but this is where speculation starts.

This this would mean this cannot be done using oral administration? My question still stands as how would the compound not be destroyed making it useless when filtered through the body without the methyl group as I thought that was one of the only reasons it was attached. Even with the injectable

 

[bob357sig]

I guess what I am saying is: who knows how the compounds would act after removal of the methyl. Possibly beneficial. Possibly not. Maybe loss of potency or androgenic activity.

This is reminding me of the Dbol/Boldenone comparison. I am no chemist by any means so i am not totally sure if I am correct but I have been told that Dbol is basically methylated Boldenone, the two compounds are structurally the same except for the methylation of the Dbol. That being said we all know Boldenone is nothing like Dbol except on paper.

 

[bob357sig]

This this would mean this cannot be done using oral administration? My question still stands as how would the compound not be destroyed making it useless when filtered through the body without the methyl group as I thought that was one of the only reasons it was attached. Even with the injectable

I believe you are correct, if Anavar wasn’t methylated it would be used in the body rapidly, probably within a few hours, it would have to have an ester attached to it to extend the half life. Just like TNE is used up in a few hours, compared to test P or any ester of test.

 

[T L]

This is reminding me of the Dbol/Boldenone comparison. I am no chemist by any means so i am not totally sure if I am correct but I have been told that Dbol is basically methylated Boldenone, the two compounds are structurally the same except for the methylation of the Dbol. That being said we all know Boldenone is nothing like Dbol except on paper.

Exactly! Thank you, Bob. This is the perfect example. Dbol is the 17-a methylated version of boldenone. And yet, as you said, both compounds are vastly different.
Anavar, for another example, is the 17-a methylated version of DHT. Meanwhile, Oxandrolone/var isn’t actually that androgenic (in comparison with DHT).

 

[Theworm]

Maybe that’s why there is primo?
Non aromatizing anabolic.

Love to have an injectible non methylated delop version of oxandrolone
I think there is a market for that.

10 years ago my hrt clinic had injectible oxandrolone but it was like 200 dollars for 10 ml of 50mg/ml concentration. So it would have been cost limited and it was not non methylated

 

[T L]

Maybe that’s why there is primo?
Non aromatizing anabolic.

Love to have an injectible non methylated delop version of oxandrolone
I think there is a market for that.

10 years ago my hrt clinic had injectible oxandrolone but it was like 200 dollars for 10 ml of 50mg/ml concentration. So it would have been cost limited and it was not non methylated

Buy some DHT because that’s really what you’re asking for here.
Anyway, why wouldn’t you just use Primobolan instead?

 

[Elistheman]

Exactly! Thank you, Bob. This is the perfect example. Dbol is the 17-a methylated version of boldenone. And yet, as you said, both compounds are vastly different.
Anavar, for another example, is the 17-a methylated version of DHT. Meanwhile, Oxandrolone/var isn’t actually that androgenic (in comparison with DHT).

No it has the structure but it is not a methylated version of DHT, in fact that is exactly what I am asking! What steroid is methylated to form oxandrolone in the first place!

 

[TAKESHI]

I don’t think I’ve ever seen any non methy derivative of anavar. The closest thing is probably this.

Furuza-A contains 50mg of 5a-etioallocholan[2,3-c]furazan-17b-tetrahydropyranol ether per pill which is a prohormone with a similar structure of Furzabol (a rare japanese oral steroid with similar effects of winstrol – stanozolol).Furuza-A can be either used in solo for cutting & recomp cycles to get lean mass. The cutting prohormone Furuza-A is a non methylated prohormone with low (or none) side effects which make it a very good choice for everyone

It’s a designer based off a Japanese steroid. Still available in the UK and EU. Very expensive to run at a proper dosage of 500-800 mg which will provide good results. Unless you have unlimited cash to burn just run Var.

 

[Elistheman]

I don’t think I’ve ever seen any non methy derivative of anavar. The closest thing is probably this.

Furuza-A contains 50mg of 5a-etioallocholan[2,3-c]furazan-17b-tetrahydropyranol ether per pill which is a prohormone with a similar structure of Furzabol (a rare japanese oral steroid with similar effects of winstrol – stanozolol).Furuza-A can be either used in solo for cutting & recomp cycles to get lean mass. The cutting prohormone Furuza-A is a non methylated prohormone with low (or none) side effects which make it a very good choice for everyone

It’s a designer based off a Japanese steroid. Still available in the UK and EU. Very expensive to run at a proper dosage of 500-800 mg which will provide good results. Unless you have unlimited cash to burn just run Var.

500-800 mg is for oral?

 

[TAKESHI]

500-800 mg is for oral?

I’ve only seen it as an oral. Ha, I might have exaggerated a little with dosages. I believe 300-400 was a good dose back in the day. I played with higher dosages a lot back then. It’s very mild. It’s good for a cut or recomp if you have money to burn. I think 60 pills are $40, so about $160 for a months supply.

 

[Dead]

What is so special about anavar I don’t get it. Do you guys just like the low side effects or something?

 

[TAKESHI]

What is so special about anavar I don’t get it. Do you guys just like the low side effects or something?

It’s great for strength at high dosages. It works great for people that are looking retain muscle on a cut or for those trying to fine tune there physique without adding unwanted mass.

 

[Elistheman]

I’ve only seen it as an oral. Ha, I might have exaggerated a little with dosages. I believe 300-400 was a good dose back in the day. I played with higher dosages a lot back then. It’s very mild. It’s good for a cut or recomp if you have money to burn. I think 60 pills are $40, so about $160 for a months supply.

wonder if i can make it an injectable... i see no reason why it shouldn't work, if i could only get raw powder..

What is so special about anavar I don’t get it. Do you guys just like the low side effects or something?

As a chemist... i have this belief (as in never seen a study) that the unique structure (the oxygen in the first ring) have additional benefits with fat metabolism.

 

[RunTrenFckTens]

You need to post this in an organic chemistry forum not meso lmao.

 

[Pineapples4Puss]

You need to post this in an organic chemistry forum not meso lmao.

Having shit like this on meso is great. Or at least I think so. The more we understand the ins and outs of compounds or any type of information we do everyday the better we become at actually thinking about things in general imo. Peel back as many layers as possible.

 

[Elistheman]

You need to post this in an organic chemistry forum not meso lmao.

Look at the address bar. It says thinksteroids. Well I think more scientific topics are welcome better then repeating topics about tren or people not knowing how to eat. We need to encourage thinking more and repeating less.