Freak Under Construction Cycle Log

[Throwback]

Im sure you know this already but just in case you need to let the suboxone clear your system before you start oxy or it will cause precipitated withdrawal from first dose

I was gonna agree with u.....wrote an entire post even then remembered its the other way around.
If your on suboxone you can eat as many opiates as you want...they just get blocked...BUT if you are on opiates and eat a sub before the opiate clears you are fucked.

 

[Whoremoans]

Im sure you know this already but just in case you need to let the suboxone clear your system before you start oxy or it will cause precipitated withdrawal from first dose

This is incorrect. You can take oxy right after taking suboxone. But if you take suboxone within a couple hours of taking oxy you will get precipitated w/d, because they compete for the receptor and with suboxone having the higher binding affinity, it kicks the oxy off the receptor, causing precip w/d.

 

[Whoremoans]

I would drop to Trt for withdrawal or at least drop the tren

I've already addressed my gear protocol for this. I'm only taking test, a small dose of anavar to prevent muscle wasting (the original medical purpose for Var) and I'm considering the primo, but I'll probably leave it out due to the pain.

 

[Just Fish]

This is incorrect. You can take oxy right after taking suboxone. But if you take suboxone within a couple hours of taking oxy you will get precipitated w/d, because they compete for the receptor and with suboxone having the higher binding affinity, it kicks the oxy off the receptor, causing precip w/d.

That's crazy, I know if you take a suboxone to early when coming off oxy you get precipitated withdrawal. I figured it would do the same the other way around. I'm sure your right but how does it cause it one way and not the other? Just curious to learn for giving future advice

 

[Just Fish]

I've already addressed my gear protocol for this. I'm only taking test, a small dose of anavar to prevent muscle wasting (the original medical purpose for Var) and I'm considering the primo, but I'll probably leave it out due to the pain.

How much var you planing on?

 

[Whoremoans]

That's crazy, I know if you take a suboxone to early when coming off oxy you get precipitated withdrawal. I figured it would do the same the other way around. I'm sure your right but how does it cause it one way and not the other? Just curious to learn for giving future advice

I already explained why. Suboxone has the higher binding affinity at the receptor. If the suboxone is already in your system and you take an oxy, nothing really happens because the suboxone prevents it from binding properly. And suboxone also contains naloxone which is an opiate blocker. Now if you have oxy in your system or other opiates, attached to the receptor, working their magic and dumping dopamine, then introduce suboxone.. The suboxone with its higher binding affinity completely kicks the oxy off the receptor which induces the worst kind of w/d you can experience.

 

[Whoremoans]

How much var you planing on?

40-60mg.

 

[Throwback]

That's crazy, I know if you take a suboxone to early when coming off oxy you get precipitated withdrawal. I figured it would do the same the other way around. I'm sure your right but how does it cause it one way and not the other? Just curious to learn for giving future advice

Suboxone uses an ingredient that blocks the opiate molecule from binding to a receptor ...suboxone is also a synthetic opiate with a slightly different synthetic opiate molecular structure.
When you take...say a roxy and it is freshly bound to your receptor....then you take a suboxone....the suboxone which has a stronger bindind affinity to that opiate recepter literally rips the opiate molecule from the receptor. Its this fight and tearing away that causes the withdrawl symptoms....
Then unlike subutex...the suboxone contains a blocking agent that keeps the opiates away from trying to hook up with your receptors.....best i can explain it.
Walter White could probably draw out the chemistry side of this alot better than me.

 

[Throwback]

I already explained why. Suboxone has the higher binding affinity at the receptor. If the suboxone is already in your system and you take an oxy, nothing really happens because the suboxone prevents it from binding properly. And suboxone also contains naloxone which is an opiate blocker. Now if you have oxy in your system or other opiates, attached to the receptor, working their magic and dumping dopamine, then introduce suboxone.. The suboxone with its higher binding affinity completely kicks the oxy off the receptor which induces the worst kind of w/d you can experience.

Sorry i see u already answered him....better than mine below.

 

[Whoremoans]

Sorry i see u already answered him....better than mine below.

Looks like a plenty good explanation to me brother.

 

[Trapmonster]

Hydrocodone would probably be better if you can get it because of less severe withdrawals than oxycodone. Grab some clonidine, too. It eases withdrawals. I believe @pharmacist carries it and it's fairly cheap.

I thought that was dependent on users. I've heard some say hydrocodone does nothing for them not even a hight and vice versa. Mg per mg it's the same, just the carrier is hydrolyzed in one the other oxidized if I'm not mistaken?

 

[Perrin Aybara]

I thought that was dependent on users. I've heard some say hydrocodone does nothing for them not even a hight and vice versa. Mg per mg it's the same, just the carrier is hydrolyzed in one the other oxidized if I'm not mistaken?

I really have no idea, I'm not familiar with the chemical makeup of them. I can't imagine either of them not doing anything for anyone though. Never heard that.

 

[Trapmonster]

I really have no idea, I'm not familiar with the chemical makeup of them. I can't imagine either of them not doing anything for anyone though. Never heard that.

I've talked to a few people that switched from one to the other cus the pain relief was not enough on one and when they switch, they're high as fuck pain free. I guess some people absorb hydro better than oxidized and vice versa

 

[Trapmonster]

And personally hydrocodone hits me harder than oxycodone

 

[Perrin Aybara]

And personally hydrocodone hits me harder than oxycodone

The problem with hydrocodone for me is the acetaminophen content. Even with 10/325 norcos you have to consume a ton of Tylenol to get enough hydrocodone. With Oxycontin at least it's pure.

 

[Trapmonster]

The problem with hydrocodone for me is the acetaminophen content. Even with 10/325 norcos you have to consume a ton of Tylenol to get enough hydrocodone. With Oxycontin at least it's pure.

ApparentlyI had percocet, as it did have acetaminophen. I was under the impression that all oxycodon has acetaminophen but not pure oxys

 

[Perrin Aybara]

ApparentlyI had percocet, as it did have acetaminophen. I was under the impression that all oxycodon has acetaminophen but not pure oxys

No, percocet is oxycodone and acetaminophen. The highest concentration is also 10/325. Oxycontin comes in 5mg, 10mg, 20mg, 30mg, 40mg, 60mg and 80mg pure oxycodone. High doses of acetacetaminophen kill my stomach.

 

[weighted chinup]

High doses of acetacetaminophen kill my stomach.

I think the high-dose acetaminophen is responsible for a lot of the 'allergies' to that drug. It was the worst thing I've ever experienced in my life, as soon as anything touched my stomach, vomit less than a minute later. Gravol didn't do shit. This was a couple days before that surgery in February, they switched it out for a stronger med instead which was far less harsh when it came to sides (hydromorphone).

 

[Perrin Aybara]

I think the high-dose acetaminophen is responsible for a lot of the 'allergies' to that drug. It was the worst thing I've ever experienced in my life, as soon as anything touched my stomach, vomit less than a minute later. Gravol didn't do shit. This was a couple days before that surgery in February, they switched it out for a stronger med instead which was far less harsh when it came to sides (hydromorphone).

Dilaudid (hydromorphone) is more potent than Oxycontin in my opinion. I don't see why they put so much acetaminophen with hydrocodone. It seems harmful.

I've actually gotten acetaminophen poisoning from too many vicodin before. It was very unpleasant and probably similar to your experience. Very painful in the gut.

 

[weighted chinup]

Dilaudid (hydromorphone) is more potent than Oxycontin in my opinion. I don't see why they put so much acetaminophen with hydrocodone. It seems harmful.

I've actually gotten acetaminophen poisoning from too many vicodin before. It was very unpleasant and probably similar to your experience. Very painful in the gut.

Definitely more potent. Generally after a big surgery they give you a long acting hydromorphone contin (hcl) that lasts for about 12 hours and the fast acting lower dosed Dilaudid which is very noticeable. You take the long acting 3x a day every 8 hours and IIRC the Dilaudid as needed. I was advised by the doc to never let pain go over a 5 or you waited to long and are about to be in a world of shit.

Everyone handles pain differently, but the sooner a patient can discontinue, the better. My advice for most people who have to go through that misery would be to probably toss whatever Dilaudid they don't end up using post-surgery.