Sicsemptyran
Member
I thought I would create a thread where I just generally post anything I find interesting, and if others do, then great. Shoutout to @egruberman for sending me down the cholesterol rabbit hole recently.
Currently am running an experiment on myself with bempedoic acid, a relatively newer drug that is quite expensive if you get it through mainstream pharmacies as its branded form Nexletol or the combo pill with ezetimibe called Nexlizet. While the main effect of bempedoic acid is to lower LDL (and ApoB), the Phase III trials had some eyebrow raising effects to me.
For one, incidents of diabetes/hyperglycemia in the treatment group were lower than placebo, entirely the opposite of what we see from statins. In addition, hematocrit was 1.6% lower in the treatment group as compared to placebo, with erythrocytes being 1.8% lower.
To me, this sounds like it would be damn near a perfect drug for bodybuilders. Lowering of LDL, mitigating erythropoietic effects, not impacting insulin sensitivity (and possibly improving it), all without the negative muscle pain from statins. There are some small side effects, such as raising uric acid, as well as a warning regarding tendon rupture. That said, in reading the studies, the tendon ruptures are likely not drug related and frankly not a worry of mine based on the data.
Am 2 weeks into this experiment and will report back with my own results and bloodwork changes when I get them!
(Multiple edits for dumb little spelling mistakes, really should have read this before posting)
Currently am running an experiment on myself with bempedoic acid, a relatively newer drug that is quite expensive if you get it through mainstream pharmacies as its branded form Nexletol or the combo pill with ezetimibe called Nexlizet. While the main effect of bempedoic acid is to lower LDL (and ApoB), the Phase III trials had some eyebrow raising effects to me.
For one, incidents of diabetes/hyperglycemia in the treatment group were lower than placebo, entirely the opposite of what we see from statins. In addition, hematocrit was 1.6% lower in the treatment group as compared to placebo, with erythrocytes being 1.8% lower.
To me, this sounds like it would be damn near a perfect drug for bodybuilders. Lowering of LDL, mitigating erythropoietic effects, not impacting insulin sensitivity (and possibly improving it), all without the negative muscle pain from statins. There are some small side effects, such as raising uric acid, as well as a warning regarding tendon rupture. That said, in reading the studies, the tendon ruptures are likely not drug related and frankly not a worry of mine based on the data.
Am 2 weeks into this experiment and will report back with my own results and bloodwork changes when I get them!
(Multiple edits for dumb little spelling mistakes, really should have read this before posting)
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