How are you using the accutane,
@Ghoul ? I have no acne but anti-aging does interest me. Do you fear long-term reduction in skin oils resulting in dryer/faster aging skin for the long haul?
I didn't realize my perpetually oily skin and hair, I've been a two shower a day guy for my entire life, was a condition called "hyper-seborrhea" until I started using accutane, and experienced "normal" skin for the first time in my life.
I finally appreciated why most people use moisturizer and hair conditioner.
On the bright side the excess oil kept my skin in much better shape than my peers, on the other hand it was likely an avoidable accelerator of androgenic alopecia, since sebum blocks pores cutting off oxygen to hair follicles, making them more susceptible to damage from DHT.
So for me, I'm hoping the reduction is permanent, at least in part, but research isn't really clear on this. In younger people hormonal (test) surges induce the sebum glands to grow (hence teenage acne), and they often go back to producing as much oil as before within a couple of years of stopping accutane treatment.
Women in their mid 30s+ seem to be the ones who experience permanent drying the most (from high dose courses only). My guess is a rapidly declining level of test to stimulate sebum gland growth.
I suspect being on TRT, high physiological levels, means I'll have some degree of rebound, which is why I'm going to the high end of daily (170mg/day) and cumulative (20,000mg or 220mg/kg) dosing, in the hopes I never go back to previous levels of sebum production.
After a recovery period, I'm going to go on a low dose regimen for skin maintainance, primarily the benefits of rapid turnover and collagen synthesis that appear very efffctive.
So the answer is, if you're not starting with excessively dry skin, and sticking to low doses, I doubt you'll have a problem. I haven't seen any documented cases of anyone using sub 40mg daily having an issue, and that's way more than the low dose anti-aging regimen. It seems to take a LOT of accutane to really bring sebum production down permanently.